Andonate
Andonate Uses, Dosage, Side Effects, Food Interaction and all others data.
Nandrolone is an anabolic steroid. It promotes tissue-building processes and protein anabolism. It also stimulates erythropoeitin production, causing an increase in haemoglobin and RBC volume.
Nandrolone decanoate is an alkylated anabolic steroid indicated in the management of anemia of renal insufficiency and as an adjunct therapy in the treatment of senile and postmenopausal osteoporosis. It has a long duration of action as it is given every 3-4 weeks, and a wide therapeutic window as acute overdoses are rare. Patients should be counselled regarding the risks of giving this drug to patients with cardiac, renal, or hepatic diseases.
| Trade Name | Andonate |
| Generic | Nandrolone Decanoate |
| Nandrolone Decanoate Other Names | Nandrolone decanoate |
| Type | Injection |
| Formula | C28H44O3 |
| Weight | Average: 428.6472 Monoisotopic: 428.329045274 |
| Protein binding | Data regarding the percent protein binding of nandrolone decanoate is not readily available. After nandrolone decanoate is hydrolyzed to nandrolone, it is bound to sex hormone binding globulin. |
| Groups | Approved, Illicit |
| Therapeutic Class | Anabolic steroid, Anabolic steroid (Androgens), Hormone in bone formation by stimulation |
| Manufacturer | Ambit Bio Medix |
| Available Country | India |
| Last Updated: | September 19, 2023 at 7:00 am |
Uses
Nandrolone decanoate is used for the management of the anemia of renal insufficiency and has been shown to increase hemoglobin and red cell mass. Surgically induced anephric patients have been reported to be less responsive.
Andonate is also used to associated treatment for these conditions: Chronic renal failure anemia, Osteoporosis (Senile), Postmenopausal Osteoporosis
How Andonate works
Nandrolone decanoate is hydrolyzed to nandrolone, possibly by PDE7B. Nandrolone is brought into cells by receptor mediated endocytosis, where it interacts with the androgen receptor. After binding to the androgen receptor, a conformational change occurs, the androgen receptor enters the nucleus, dimerizes, and can then bind to segments of DNA to regulate transcription. Androgens can also regulate transcription through activation of ERK, Akt, and MAPK; or binding to and competitively inhibiting transcription factors.
Dosage
Andonate dosage
Anaemia in chemotherapy patients: 50-150 mg wkly.
Anabolic after debilitating illness, Postmenopausal osteoporosis, Metastatic breast cancer: 25-100 mg once every 3-4 wk.
Anaemia of chronic renal failure: 50-200 mg wkly.
Side Effects
Male: Postpubertal: Acne, gynaecomastia, bladder irritability, priapism, insomnia, chills, decreased libido, hepatic dysfunction, nausea, diarrhoea, prostatic hyperplasia.
Prepubertal: Acne, virilism, chills, insomnia, hyperpigmentation, diarrhoea, nausea.
Female: Virilism, hypercalcaemia, nausea, diarrhoea, chills, insomnia, iron deficiency anaemia, hepatic dysfunction.
Toxicity
Data regarding acute overdose of nandrolone decanoate are not readily available. However, patients experiencing a chronic overdose of anabolic steroids may experience adverse effects including suppression of testosterone and spermatogenesis, shrinking of testicles, decreased libido, and erectile dysfunction in men; and suppressed estrogen, progesterone, and ovulation, amenorrhea, and clitoromegaly in women. Patients may also experience neuropsychiatric, cardiovascular, and hepatic adverse effects. Alkylated anabolic steroids such as nandrolone decanoate are more likely to cause hepatic adverse effects. Treat patients with symptomatic and supportive measures.
The intraperitoneal LD50 in mice is >566 mg/kg.
Precaution
Monitor diabetic patients carefully. Conditions influenced by oedema (e.g. CV disease, migraine, seizure disorder, renal impairment). Hepatic impairment. Elderly. Discontinue if signs of virilisation in women occur. Monitor skeletal maturation in children.
Interaction
May increase effects of oral anticoagulants, insulin, oral antidiabetic agents, adrenal steroid, adrenocorticotropic hormone (ACTH).
Food Interaction
No interactions found.Elimination Route
A 50 mg intramuscular dose of nandrolone decanoate reaches a mean Cmax 2.14 ng/mL, with a mean Tmax of 30 hours, and a mean AUC of 400 h*ng/mL. A 100 mg intramuscular dose of nandrolone decanoate reaches a mean Cmax 4.26 ng/mL, with a mean Tmax of 30 hours, and a mean AUC of 862 h*ng/mL. A 150 mg intramuscular dose of nandrolone decanoate reaches a mean Cmax 5.16 ng/mL, with a mean Tmax of 72 hours, and a mean AUC of 1261 h*ng/mL.
Half Life
Nandrolone decanoate has an absorption half life of 6 days and an elimination half life of 4.3 hours. Alternate studies have shown that nandrolone decanoate has a terminal half life of 7.1, 11.7, and 11.8 hours for doses of 50, 100, and 150 mg respectively.
Clearance
50 mg, 100 mg, and 150 mg doses of nadrolone decanoate had mean apparent clearances of 80.0 L/h, 74.3 L/h, and 76.2 L/h respectively.
Elimination Route
Nandrolone decanoate is eliminated as urinary metabolites, however data regarding elimination in the feces are not readily available. Data in cattle shows that nandrolone is 30% eliminated in the feces.
Pregnancy & Breastfeeding use
Pregnancy Category X. Studies in animals or human beings have demonstrated foetal abnormalities or there is evidence of foetal risk based on human experience or both, and the risk of the use of the drug in pregnant women clearly outweighs any possible benefit. The drug is contraindicated in women who are or may become pregnant.
Contraindication
Prostatic or breast carcinoma (male); nephrosis, porphyria; infants, pregnancy and lactation.
Innovators Monograph
You find simplified version here Andonate
FAQ
What is Andonate used for?
Andonate is an androgen and anabolic steroid medication which is used primarily in the treatment of anemias and wasting syndromes, as well as osteoporosis in menopausal women.
How safe is Andonate?
Andonate has beneficial effects on weight, lean body mass and quality of life in selected patients who have mild to moderate HIV wasting. Weekly Andonate treatment and lower extremity resistance exercise training during dialysis for 12 week were safe and well tolerated. No subject experienced toxicity.
How does Andonate work?
Andonate acts as an androgen receptor agonist that is not converted endogenously to DHT. As such, it provides negative feedback to the HPG axis to suppresses testosterone levels, further decreasing the available testosterone and DHT, compounding its negative effects on erectile function.
What are the common side effects of Andonate?
Its consumption can trigger a series of adverse side effects in the body, both acute and chronic. However, acute adverse effects have also been described, primarily consisting of headaches, fluid retention, gastrointestinal irritation, diarrhea, abdominal pain, jaundice, menstrual abnormalities, and hypertension.
Is Andonate safe during pregnancy?
There are no controlled data in human pregnancy. Andonate is considered contraindicated during pregnancy.
Is Andonate safe during breastfeeding?
Because many drugs are excreted into human milk and because of the potential for adverse effects on the nursing infant, a decision should be made to discontinue nursing or discontinue the drug, taking into account the importance of Andonate to the woman.
What is the half life of Andonate?
The half-life for the combined process of hydrolysis of Andonate and of distribution and elimination of Andonate is 4.3 hours.
Does Andonate build muscle?
Andonate preferentially stimulates growth of skeletal muscle and lean body mass that may provide benefit in reducing components of metabolic syndrome.
Can Andonate cause hair loss?
Andonate should not cause much hair loss.
How often can I take Andonate?
Dosages. A dosage of Andonate of 25 to 50 mg once every 6 to 12 weeks (working out to an average exposure of about 2 to 8 mg per week) by intramuscular injection is considered to be appropriate for general androgen replacement therapy in women.
How long does it take for Andonate to work?
There is a sharp spike in Andonate levels 24 to 48 hours after an intramuscular injection of Andonate, followed by a steady decline to baseline levels within approximately two or three weeks.
Is Andonate bad for my heart?
Administration of Andonate caused DNA damage to heart tissue, indicated by an increased 8-OHdG level in heart tissue.
Who should not take Andonate?
You should not take Andonate If you have any symptom of below:
- high blood calcium from metastatic breast cancer.
- breast cancer in a male patient.
- cancer of the prostate gland.
How long does Andonate last?
The elimination half-life of Andonate administered by intramuscular injection is approximately 6 to 12 days.
What happen If I missed dose of Andonate?
Take the missed dose as soon as possible. However, if you do not remember it until the next day, skip the missed dose and go back to your regular dosing schedule. Do not double doses.
What happens if I overdose of Andonate?
If you think there has been an overdose, call your poison control center or get medical care right away. Be ready to tell or show what was taken, how much, and when it happened.
Do Andonate affect my kidneys?
Andonate can affect the kidney in different aspects. They can induce or aggravate acute kidney injury, chronic kidney disease, and glomerular toxicity.
Can Andonate affect my fertility?
Andonate can harm male fertility the same way that testosterone does,by interfering with the hormone signals that are needed to produce sperm.
Can Andonate affects my liver?
These results suggest that subchronic treatment with Andonate, mainly administered at higher-than-clinical doses, are potentially deleterious to the liver, leading to incipient fibrosis.
