Anisoylated Plasminogen Streptokinase Activator Complex

Anisoylated Plasminogen Streptokinase Activator Complex Uses, Dosage, Side Effects, Food Interaction and all others data.

Human tissue plasminogen activator, purified, glycosylated, 527 residues purified from CHO cells. Eminase is a lyophilized (freeze-dried) formulation of anistreplase, the p-anisoyl derivative of the primary Lys-plasminogen-streptokinase activator complex (a complex of Lys-plasminogen and streptokinase). A p-anisoyl group is chemically conjugated to a complex of bacterial-derived streptokinase and human Plasma-derived Lys-plasminogen proteins.

Anisoylated Plasminogen Streptokinase Activator Complex cleaves the Arg/Val bond in plasminogen to form plasmin. Plasmin in turn degrades the fibrin matrix of the thrombus, thereby exerting its thrombolytic action. This helps eliminate blood clots or arterial blockages that cause myocardial infarction.

Table Of contents

• Anisoylated Plasminogen Streptokinase Activator Complex
• Uses
• Dosage
• Side Effect
• Precautions
• Interactions
• Uses during Pregnancy
• Uses during Breastfeeding
• Accute Overdose
• Food Interaction
• Half Life
• Volume of Distribution
• Clearance
• Interaction With other Medicine
• Contradiction
• Storage

Trade Name	Anisoylated Plasminogen Streptokinase Activator Complex
Availability	Discontinued
Generic	Anistreplase
Anistreplase Other Names	Anisoylated plasminogen streptokinase activator complex, Anistreplase, APSAC
Related Drugs	aspirin, lisinopril, metoprolol, propranolol, Plavix, Brilinta
Type
Formula	C2569H3928N746O781S40
Weight	59042.3 Da
Groups	Approved
Therapeutic Class
Manufacturer
Available Country
Last Updated:	September 19, 2023 at 7:00 am

Uses

Anisoylated Plasminogen Streptokinase Activator Complex is a form of recombinant human tissue plasminogen activator used in the emergency treatment of myocardial infarction and pulmonary emboli.

For lysis of acute pulmonary emboli, intracoronary emboli and management of myocardial infarction

How Anisoylated Plasminogen Streptokinase Activator Complex works

Anisoylated Plasminogen Streptokinase Activator Complex cleaves the Arg/Val bond in plasminogen to form plasmin. This in turn leads to the degradation of blood clots.

Food Interaction

• Avoid herbs and supplements with anticoagulant/antiplatelet activity. Examples include garlic, ginger, bilberry, danshen, piracetam, and ginkgo biloba.

Anisoylated Plasminogen Streptokinase Activator Complex Hypertension interaction

[Major] The use of thrombolytics is contraindicated in patients with an active bleed (internal), trauma

Risk versus benefit should be carefully considered in the following conditions and thrombolytic therapy administered with caution in patients with recent (10 days) serious GI bleed or recent (10 days) surgical procedure (coronary bypass graft, obstetrical delivery, organ biopsy, puncture of noncompressible vessel), left heart thrombus, subacute bacterial endocarditis, hemostatic defect, CV disease, diabetic hemorrhagic retinopathy, or pregnancy.

Clinical monitoring of hematopoietic, bleeding and coagulation functions is recommended prior to initiation of thrombolytic therapy.

Measures of fibrinolytic activity and

Anisoylated Plasminogen Streptokinase Activator Complex Drug Interaction

Moderate: aspirin, aspirinUnknown: acetaminophen, acetaminophen, alfentanil, alfentanil, alprazolam, alprazolam, etomidate, etomidate, lubiprostone, lubiprostone, coagulation factor Xa, coagulation factor Xa, insulin glulisine, insulin glulisine, pseudoephedrine / triprolidine, pseudoephedrine / triprolidine, darbepoetin alfa, darbepoetin alfa

Anisoylated Plasminogen Streptokinase Activator Complex Disease Interaction

Major: bleeding risks

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