Anti-CD11a
Anti-CD11a Uses, Dosage, Side Effects, Food Interaction and all others data.
Humanized IgG1 kappa isotype monoclonal antibody that binds to human CD11a. Anti-CD11a has a molecular weight of approximately 150 kilodaltons and is produced in a Chinese hamster ovary mammalian cell expression system in a nutrient medium containing the antibiotic gentamicin.
Lymphocyte activation and trafficking to skin play a role in the pathophysiology of chronic plaque psoriasis. In psoriatic skin, ICAM-1 cell surface expression is upregulated on endothelium and keratinocytes. Raptiva inhibits the binding of LFA-1 to the intercellular adhesion molecule-1 (ICAM-1), thereby inhibiting the adhesion of leukocytes to other cell types.
| Trade Name | Anti-CD11a |
| Availability | Discontinued |
| Generic | Efalizumab |
| Efalizumab Other Names | anti-CD11a, antiCD11 alpha, Efalizumab |
| Related Drugs | Humira, Otezla, Cosentyx, methotrexate, Enbrel, Remicade, Stelara, cyclosporine, infliximab |
| Type | |
| Groups | Approved, Investigational |
| Therapeutic Class | |
| Manufacturer | |
| Available Country | |
| Last Updated: | September 19, 2023 at 7:00 am |
Uses
Anti-CD11a is a monoclonal anti-CD11a antibody used to treat moderate to severe plaque psoriasis.
For the treatment of adult patients with moderate to severe chronic plaque psoriasis, who are candidates for phototherapy or systemic therapy.
Anti-CD11a is also used to associated treatment for these conditions: Moderate to Severe Chronic Plaque Psoriasis
How Anti-CD11a works
Anti-CD11a binds to CD11a, a subunit of leukocyte function antigen-1 (LFA-1), which is expressed on all leukocytes. As a result efalizumab decreases cell surface expression of CD11a.
Elimination Route
Average efalizumab bioavailability following subcutaneous administration was estimated at 30 to 50%.
Half Life
5 days
Innovators Monograph
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