Antrenyl Duplex

Antrenyl Duplex Uses, Dosage, Side Effects, Food Interaction and all others data.

Antrenyl Duplex is an anticholinergic drug, a medication that reduces the effect of acetylcholine, a chemical released from nerves that stimulates muscles, by blocking the receptors for acetylcholine on smooth muscle (a type of muscle). It also has a direct relaxing effect on smooth muscle. Antrenyl Duplex is used to treat or prevent spasm in the muscles of the gastrointestinal tract in the irritable bowel syndrome. In addition, Antrenyl Duplex inhibits gastrointestinal propulsive motility and decreases gastric acid secretion and controls excessive pharyngeal, tracheal and bronchial secretions.

Antrenyl Duplex
Uses
Dosage
Side Effect
Precautions
Interactions
Uses during Pregnancy
Uses during Breastfeeding
Accute Overdose
Food Interaction
Half Life
Volume of Distribution
Clearance
Interaction With other Medicine
Contradiction
Storage

Trade Name	Antrenyl Duplex
Generic	Oxyphenonium
Oxyphenonium Other Names	Oxyphenonium ion
Type	Tablet
Formula	C₂₁H₃₄NO₃
Weight	Average: 348.4996 Monoisotopic: 348.253868959
Protein binding	93% bound to albumin
Groups	Approved
Therapeutic Class	Anticholinergics (antimuscarinics)/ Anti-spasmodics
Manufacturer	Novartis India Ltd
Available Country	India
Last Updated:	September 19, 2023 at 7:00 am

Uses

Abdominal pain, Colic, Gastrointestinal tract spasm, Peptic ulcer disease, Visceral spasms

How Antrenyl Duplex works

Action is achieved via a dual mechanism: (1) a specific anticholinergic effect (antimuscarinic) at the acetylcholine-receptor sites and (2) a direct effect upon smooth muscle (musculotropic).

Dosage

Antrenyl Duplex dosage

Adult: 1-2 tablets 3-4 times daily

Children: ½ to 1 tablets 1-3 times daily

Side Effects

Dryness of mouth, difficulty in talking/swallowing; reduced bronchial secretions; blurring of vision, photophobia; bradycardia followed by tachycardia and arrhythmias; urinary retention, constipation, vomiting, nausea; confusion and giddiness.

Precaution

Children; elderly; benign prostatic hyperplasia; acute MI, cardiac failure, hypertension, thyrotoxicosis; pregnancy and lactation; fever; angle-closure glaucoma.

Interaction

Reduced gastric motility interferes with absorption of other drugs. Effects potentiated by other antimuscarinics including amantadine, some antihistamines, phenothiazines and TCA.

Pregnancy & Breastfeeding use

Category C: Either studies in animals have revealed adverse effects on the foetus (teratogenic or embryocidal or other) and there are no controlled studies in women or studies in women and animals are not available. Drugs should be given only if the potential benefit justifies the potential risk to the foetus.