Antrenyl Duplex

Antrenyl Duplex Uses, Dosage, Side Effects, Food Interaction and all others data.

Antrenyl Duplex is an anticholinergic drug, a medication that reduces the effect of acetylcholine, a chemical released from nerves that stimulates muscles, by blocking the receptors for acetylcholine on smooth muscle (a type of muscle). It also has a direct relaxing effect on smooth muscle. Antrenyl Duplex is used to treat or prevent spasm in the muscles of the gastrointestinal tract in the irritable bowel syndrome. In addition, Antrenyl Duplex inhibits gastrointestinal propulsive motility and decreases gastric acid secretion and controls excessive pharyngeal, tracheal and bronchial secretions.

Trade Name Antrenyl Duplex
Generic Oxyphenonium
Oxyphenonium Other Names Oxyphenonium ion
Type Tablet
Formula C21H34NO3
Weight Average: 348.4996
Monoisotopic: 348.253868959
Protein binding

93% bound to albumin

Groups Approved
Therapeutic Class Anticholinergics (antimuscarinics)/ Anti-spasmodics
Manufacturer Novartis India Ltd
Available Country India
Last Updated: September 19, 2023 at 7:00 am
Antrenyl Duplex
Antrenyl Duplex

Uses

Abdominal pain, Colic, Gastrointestinal tract spasm, Peptic ulcer disease, Visceral spasms

How Antrenyl Duplex works

Action is achieved via a dual mechanism: (1) a specific anticholinergic effect (antimuscarinic) at the acetylcholine-receptor sites and (2) a direct effect upon smooth muscle (musculotropic).

Dosage

Antrenyl Duplex dosage

Adult: 1-2 tablets 3-4 times daily

Children: ½ to 1 tablets 1-3 times daily

Side Effects

Dryness of mouth, difficulty in talking/swallowing; reduced bronchial secretions; blurring of vision, photophobia; bradycardia followed by tachycardia and arrhythmias; urinary retention, constipation, vomiting, nausea; confusion and giddiness.

Precaution

Children; elderly; benign prostatic hyperplasia; acute MI, cardiac failure, hypertension, thyrotoxicosis; pregnancy and lactation; fever; angle-closure glaucoma.

Interaction

Reduced gastric motility interferes with absorption of other drugs. Effects potentiated by other antimuscarinics including amantadine, some antihistamines, phenothiazines and TCA.

Pregnancy & Breastfeeding use

Category C: Either studies in animals have revealed adverse effects on the foetus (teratogenic or embryocidal or other) and there are no controlled studies in women or studies in women and animals are not available. Drugs should be given only if the potential benefit justifies the potential risk to the foetus.

Contraindication

Urinary outflow obstruction, paralytic ileus, myasthenia gravis.

Innovators Monograph

You find simplified version here Antrenyl Duplex

*** Taking medicines without doctor's advice can cause long-term problems.
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