Ao Rui Xin
Ao Rui Xin Uses, Dosage, Side Effects, Food Interaction and all others data.
Ao Rui Xin is an anti-inflammatory drug used in the treatment of Inflammatory Bowel Disease. It is sold under the name "Colazal" in the US and "Colazide" in the UK.
The chemical name is (E)-5-[[-4-(2-carboxyethyl) aminocarbonyl] phenyl]azo] -2-hydroxybenzoic acid. It is usually administered as the disodium salt.
Ao Rui Xin works by deliverying mesalazine to the large intestine to act directly on ulcerative colitis. Mesalazine is also known as 5-aminosalicylic acid, or 5-ASA.
| Trade Name | Ao Rui Xin |
| Availability | Prescription only |
| Generic | Balsalazide |
| Balsalazide Other Names | Balsalazida, Balsalazide, Balsalazidum |
| Related Drugs | Lialda, Pentasa, Apriso, Azulfidine, Asacol, Canasa, Delzicol, Asacol HD, Dipentum, Rowasa |
| Type | |
| Formula | C17H15N3O6 |
| Weight | Average: 357.3175 Monoisotopic: 357.096085227 |
| Protein binding | ≥99% |
| Groups | Approved, Investigational |
| Therapeutic Class | |
| Manufacturer | |
| Available Country | China |
| Last Updated: | September 19, 2023 at 7:00 am |
Uses
Ao Rui Xin is an aminosalicylate used to treat ulcerative colitis.
For the treatment of mildly to moderately active ulcerative colitis.
Ao Rui Xin is also used to associated treatment for these conditions: Mild Ulcerative Colitis, Moderate Ulcerative colitis
How Ao Rui Xin works
The mechanism of action of 5-aminosalicylic acid is unknown, but appears exert its anti-inflammatory effects locally (in the GI tract) rather than systemically. Mucosal production of arachidonic acid metabolites, both through the cyclooxygenase pathways (catalyzes the formation of prostaglandin precursors from arachidonic acid), and through the lipoxygenase pathways (catalyzes the formation of leukotrienes and hydroxyeicosatetraenoic acids from arachidonic acid and its metabolites), is increased in patients with chronic inflammatory bowel disease. Therefore, it is possible that 5-aminosalicylic acid diminishes inflammation by blocking production of arachidonic acid metabolites in the colon through both the inhibition of cyclooxygenase and lipoxygenase.
Toxicity
A single oral dose of balsalazide disodium at 5 grams/kg or 4-aminobenzoyl-(beta)-alanine, a metabolite of balsalazide disodium, at 1 gram/kg was non-lethal in mice and rats. No symptoms of acute toxicity were seen at these doses.
Food Interaction
- Take with or without food.
Ao Rui Xin Drug Interaction
Unknown: zolpidem, zolpidem, aspirin, aspirin, duloxetine, duloxetine, omega-3 polyunsaturated fatty acids, omega-3 polyunsaturated fatty acids, adalimumab, adalimumab, metoprolol, metoprolol, acetaminophen, acetaminophen, cyanocobalamin, cyanocobalamin, ascorbic acid, ascorbic acid, cholecalciferol, cholecalciferol
Ao Rui Xin Disease Interaction
Elimination Route
Low and variable, intact balsalazide is poorly absorbed systemically.
Half Life
Half-life could not be determined.
Elimination Route
The products of the azoreduction of this compound, 5-ASA and 4-aminobenzoyl-ß-alanine, and their N-acetylated metabolites have been identified in plasma, urine and feces. Following single-dose administration of 2.25 g COLAZAL (three 750 mg capsules) under fasting conditions in healthy subjects, mean urinary recovery of balsalazide, 5-ASA, and N-Ac-5-ASA was 0.20%, 0.22% and 10.2%, respectively.
Innovators Monograph
You find simplified version here Ao Rui Xin
