Apo-Risedronate

Apo-Risedronate Uses, Dosage, Side Effects, Food Interaction and all others data.

Risedronate has an affinity for hydroxyapatite crystals in bone and acts as an antiresorptive agent. At the cellular level, Risedronat inhibits osteoclasts. The osteoclasts adhere normally to the bone surface, but show evidence of reduced active resorption.

Trade Name Apo-Risedronate
Generic Risedronate Sodium
Type
Therapeutic Class Bisphosphonate preparations
Manufacturer
Available Country Canada, United States
Last Updated: September 19, 2023 at 7:00 am
Apo-Risedronate
Apo-Risedronate

Uses

This is in a group of medicines called bisphosphonates. It alters the cycle of bone formation and breakdown in the body. It slows bone loss while increasing bone mass, which may prevent bone fractures. Risedronate is a prescription medicine used:

  • To prevent and treat osteoporosis in postmenopausal women.
  • To increase bone mass in men with osteoporosis.
  • To prevent and treat osteoporosis in men and women that is caused by treatment with steroid medicines such as prednisone.
  • To treat Paget’s disease of bone in men and women.

Dosage

Apo-Risedronate dosage

Treatment of postmenopausal osteoporosis, to reduce the risk of vertebral fractures. Treatment ofestablished postmenopausal osteoporosis, to reduce the risk of hip fractures: The recommendeddose is Apo-Risedronate 5 mg once daily or Apo-Risedronate 35 mg once weekly on the same day each week or Apo-Risedronate 150 mg once monthly.

Prevention of osteoporosis in postmenopausal women with increased risk of osteoporosis: Therecommended dose is Apo-Risedronate 5 mg once daily.

To maintain or increase bone mass in postmenopausal women undergoing long-term (more than3 months): Systemic corticosteroid treatment at doses 7.5 mg/day prednisone or equivalent. Therecommended dose is Apo-Risedronate 5 mg once daily.

Treatment of osteoporosis in men at high risk of fractures: The recommended dose is Apo-Risedronate 35 mg once weekly. The tablet should be taken on the same dayeach week.

The absorption of Apo-Risedronate is affected by food, thus to ensure adequate absorption patients should take Risedronate tablets at least 30 minutes before the first food, other medicinal product or drink (other than plain water) of the day. In the particular instances that before breakfast dosing is not practical, Risedronate 5 mg tablet can be taken between meals or in the evening at the same time everyday, with strict adherence to the following instructions, to ensure Apo-Risedronate tablet is taken on an empty stomach-Between meals:

Apo-Risedronate tablet should be taken at least 2 hours before and at least 2 hours after any food, medicinal product or drink (other than plain water). In the evening:

Apo-Risedronate tablet should be taken at least 2 hours after the last food, medicinal product or drink (other than plain water) of the day. If a dose is missed: Risedronate 5 mg tablet: If an occasional dose is missed, Risedronate 5 mg tablet can be taken before breakfast, between meals, or in the evening according to the instructions above.

Risedronate 35 mg tablet: Patients should be instructed that if a dose is missed, just take one Risedronate 35 mg tablet on the morning after remember. Patients should then return to taking one tablet once a week on the day the tablet is normally taken. Two tablets should not be taken on the same day.

Risedronate 150 mg tablet: Patient should be instructed that if a dose is missed and the next month’s schedule dose is more than 7 days away, then should take the missed tablet in the morning after the day it is remembered. Patients should then return to taking one tablet once a month normally taken.The tablet must be swallowed whole and not sucked or chewed. To aid delivery of the tablet to the stomach Risedronate tablet is to be taken while in an upright position with a glass of plain water (120 ml or more). Patients should not lie down for 30 minutes after taking the tablet. Supplemental calcium and vitamin D should be considered if the dietary intake is inadequate.

Side Effects

Serious side effects:

  • chest pain;
  • difficulty or pain when swallowing;
  • pain or burning under the ribs or in the back;
  • new or worsening heartburn;
  • severe joint, bone, or muscle pain; or
  • jaw pain, numbness, or swelling.

Less serious side effects:

  • mild heartburn or stomach upset;
  • diarrhea, gas,or constipation;
  • mild joint or back pain;
  • headache.

Precaution

Take special care with Risedronate if you:

  • Have low blood calcium (hypocalcemia)
  • Cannot sit or stand up for 30 minutes
  • Have kidneys that work poorly
  • Have an allergy to Apo-Risedronate

Before taking Risedronate talk to doctor if you:

  • Are pregnant or may become pregnant. We do not know if Apo-Risedronate can harm your unborn child.
  • Are breast-feeding or plan to breast-feed. We do not know if Apo-Risedronate can passthrough your milk and if it can harm your baby.
  • Have kidney problems Apo-Risedronate may not be right for you.
  • Risedronate sodium is not intended for use in children.

During treatment, if you experience an allergic reaction (such as swelling of the face, tongue or throat, difficulty in breathing or swallowing, skin rash), you must stop taking Risedronate sodium and seek medical advice immediately. If you have stopped treatment due to hypersensitivity reactions you should not re-start therapy with Risedronate sodium.

Interaction

Please tell your doctor if you are taking or have recently taken any other medicines, including medicines obtained without a prescription specially aspirin or other NSAIDs. Antacids, supplements, or medicines that contain aluminum, calcium, magnesium, or other minerals can interfere with how your body absorbs Apo-Risedronate. If you use these other medicines, do not take them for at least 30 minutes after taking a Apo-Risedronate tablet.

Pregnancy & Breastfeeding use

Pregnancy: Apo-Risedronate is meant for use only in postmenopausal women. Therefore, Apo-Risedronate should not be taken during pregnancy. If you take it by accident during pregnancy, stop taking it straight away and talk to your doctor.

Breast-feeding: Apo-Risedronate is meant for use only in postmenopausal women. Therefore, breast-feeding women should not take this medicine. If you take it by accident during breast-feeding, stop taking it straight away and talk to your doctor.

Contraindication

Apo-Risedronate tablet is contraindicated in patients with known hypersensitivity to Apo-Risedronate and in patients with hypocalcaemia, severe renal impairment (creatinine clearance lower than 30 ml/min), during pregnancy and lactation.

Special Warning

Elderly: No dosage adjustment is necessary since bioavailability, distribution and elimination were similar in elderly (60 years of age or older) compared to younger subjects. This has also been shown in the very elderly, 75 years old and above postmenopausal population.

Renal impairment: No dosage adjustment is required for those patients with mild to moderate renal impairment. The use of Apo-Risedronate is contra-indicated in patients with severe renal impairment (Creatinine clearance lower than 30ml/min).

Acute Overdose

Seek emergency medical attention if you think you have used too much of this medicine. Drink a full glass of milk right away. Do not make yourself vomit and do not lie down.

Overdose symptoms may include nausea, heartburn, stomach pain, diarrhea, muscle cramps, numbness or tingling, tight muscles in your face, seizure (convulsions), irritability, and unusual thoughts or behavior.

Storage Condition

Store in a cool and dry place. Protect from light & moisture. Keep out of the reach of children.

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FAQ

What is Apo-Risedronate used for?

Apo-Risedronate used to helps your bones stay as strong as possible. It can help if you have or are at risk of getting a health problem called osteoporosis. This is where your bones get weaker and more likely to break.

How safe is Apo-Risedronate?

There are concerns about the long-term safety of bisphosphonates because long-term use has been associated with atypical femur fractures, osteonecrosis of the jaw, and esophageal cancer. Fracture risk reduction may also persist for years after treatment has stopped.

What are the common side effects of Apo-Risedronate?

Common side effects of Apo-Risedronate are include:

  • constipation.
  • diarrhoea.
  • indigestion, bloating, stomach pain or wind.
  • feeling sick (nausea)
  • headaches.
  • mild muscle, bone or joint pain.


Is Apo-Risedronate safe during pregnancy?

There is a theoretical risk of fetal harm, predominantly skeletal, if a woman becomes pregnant after completing a course of bisphosphonate therapy.

Is Apo-Risedronate safe during breastfeeding?

Some authorities advise against breastfeeding during use. Studies in rat pups indicate a small degree of lacteal transfer. This drug is poorly absorbed orally so absorption by a breastfed infant is unlikely, however, due to lack of information, an alternate drug may be preferred.

Can I drink alcohol with Apo-Risedronate?

The use of drinks that contain alcohol can increase your risk of certain side effects from Apo-Risedronate. These include stomach upset and diarrhea. If you drink alcohol, talk to your doctor about whether this drug is safe for you.

When should I take Apo-Risedronate?

Take the Apo-Risedronate tablet first thing in the morning with a full glass of water, at least 30 minutes before you eat or drink anything or take any other medicine.

How should I take Apo-Risedronate?

Most people take it as a weekly tablet, but it may be taken daily. Take Apo-Risedronate first thing in the morning, at least 30 minutes before you have anything to eat or drink and before you take any other medicines.

What happens if I take Apo-Risedronate with food?

Food and beverages will decrease the amount of Apo-Risedronate absorbed by the body.

Does Apo-Risedronate cause joint pain?

Apo-Risedronate can cause severe bone, joint, or muscle pain. If you have these symptoms, stop taking this drug and call your doctor.

Does Apo-Risedronate increase bone density?

Apo-Risedronate can  increases bone mineral density.

How long after eating can you take Apo-Risedronate?

Take it on an empty stomach, at least 30 minutes before you have anything to eat or drink and before you take any other medicines or supplements.

How long does Apo-Risedronate stay in my system?

Approximately half of the absorbed dose is excreted in urine within 24 hours.

Can Apo-Risedronate cause kidney stones?

Administration of calcium may increase the risk of kidney stones, particularly in patients with a history of this condition.

Can Apo-Risedronate cause kidney problems?

Apo-Risedronate had minimal to no adverse effects on kidney function. Renal-transplant patients receiving long-term glucocorticoid treatment are at greater risk for bone deterioration because of pre-existing renal dysfunction.

Who should not take Apo-Risedronate?

You should not take Apo-Risedronate if you have problems with your esophagus, or low levels of calcium in your blood. Do not take Apo-Risedronate if you cannot sit upright or stand for at least 30 minutes after taking the medicine.

What happens if I miss a dose?

If you forget to take Apo-Risedronate first thing in the morning, do not take it later in the day. Wait until the following morning and skip the missed dose. Do not take two (2) doses in one day.

What happens if I overdose?

Drink a full glass of milk and seek emergency medical attention.

When should I stop taking Apo-Risedronate?

you should stop taking Apo-Risedronate after 3 to 5 years in patients at low risk of fracture.


*** Taking medicines without doctor's advice can cause long-term problems.
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