Aptol Duriles

Aptol Duriles Uses, Dosage, Side Effects, Food Interaction and all others data.

One of the adrenergic beta-antagonists used as an antihypertensive, anti-anginal, and anti-arrhythmic agent. Aptol Duriles is no longer marketed by AstraZeneca, but may still be available in generic varieties.

Aptol Duriles is a non-selective beta-blocker used in the treatment of hypertension, edema, ventricular tachycardias, and atrial fibrillation. Aptol Duriles impairs AV node conduction and decreases sinus rate and may also increase plasma triglycerides and decrease HDL-cholesterol levels. Aptol Duriles is nonpolar and hydrophobic, with low to moderate lipid solubility. Aptol Duriles has little to no intrinsic sympathomimetic activity and, unlike some other beta-adrenergic blocking agents, alprenolol has little direct myocardial depressant activity and does not have an anesthetic-like membrane-stabilizing action.

Aptol Duriles
Uses
Dosage
Side Effect
Precautions
Interactions
Uses during Pregnancy
Uses during Breastfeeding
Accute Overdose
Food Interaction
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Trade Name	Aptol Duriles
Generic	Alprenolol
Alprenolol Other Names	Alfeprol, Alprenolol, Alprénolol, Alprenololum, Aprenololo
Type
Formula	C₁₅H₂₃NO₂
Weight	Average: 249.3486 Monoisotopic: 249.172878985
Protein binding	80-90%
Groups	Experimental, Withdrawn
Therapeutic Class
Manufacturer
Available Country
Last Updated:	September 19, 2023 at 7:00 am

Uses

For the treatment of hypertension, angina, and arrhythmia

How Aptol Duriles works

Aptol Duriles non-selectively blocks beta-1 adrenergic receptors mainly in the heart, inhibiting the effects of epinephrine and norepinephrine resulting in a decrease in heart rate and blood pressure. Also, with a more minor effect, by binding beta-2 receptors in the juxtaglomerular apparatus, alprenolol inhibits the production of renin, thereby inhibiting angiotensin II and aldosterone production and therefore inhibits the vasoconstriction and water retention due to angiotensin II and aldosterone, respectively.