Aqupla
Aqupla Uses, Dosage, Side Effects, Food Interaction and all others data.
Aqupla is a second generation platinum analog . It is less nephrotoxic than Cisplatin but has proven equally effective. It was approved for use in Japan in 1995.
Aqupla damages DNA and induces cell death in cancer cells . It also functions as a radiosensitizer, increasing the susceptibility of the affected cells to radiation therapy .
| Trade Name | Aqupla |
| Generic | Nedaplatin |
| Nedaplatin Other Names | CDGP, Nedaplatin |
| Type | |
| Formula | C2H8N2O3Pt |
| Weight | Average: 303.181 Monoisotopic: 303.018284 |
| Protein binding | Approximately 50% of the platinum from nedaplatin appears to be bound to human plasma proteins . |
| Groups | Approved, Investigational |
| Therapeutic Class | |
| Manufacturer | |
| Available Country | |
| Last Updated: | September 19, 2023 at 7:00 am |
Uses
Used in the treatment of non-small cell lung cancer, small cell lung cancer, oesophygeal cancer, and head and neck cancers .
How Aqupla works
As a platinum analog, nedaplatin likely works similarly to Cisplatin on which the following mechanistic description is based. Once it has entered the cell it is hydrolyzed to its active form which complexes with water molecules . This form binds to to nucleophiles in the cytoplasm such as glutathione and other cyteine rich proteins resulting in an overall increase in oxidative stress as the cell loses antioxidant proteins. It also binds to purine nucleotides in the DNA. The active form allows for two binding interactions to form cross-links between these nucleotides. High mobility group proteins-1 and -2 induce apoptosis in response to guanine cross-links and their binding serves to shield the cross-linked DNA from repair mechanisms. The mismatch repair (MMR) protein complex also recognizes the distortion caused by platinum complexes and attempts to repair the DNA. This results in single strand breaks when the MMR complex attempts to remove the platinum cross-link. The MMR complex induces apoptosis after the repair attempt has failed. The single strand break in DNA makes it easier to form lethal double strand breaks with radiation treatment thus creating the radiosensitizing effect of nedaplatin .
Toxicity
The toxic effects of nedaplatin are likely similar to those of Cisplatin which produces nausea, vomiting, peripheral neuropathy, and ototoxicity . A major difference between the compounds is the large reduction in nephrotoxicity of nedaplatin compared to Cisplatin .
Volume of Distribution
The volume of distribution of free platinum is 12.0 L .
Clearance
Clearance of the free platinum is 4.47 L/h .
Elimination Route
Most of the platinum from nedaplatin is eliminated in the urine (59.6%) .
Innovators Monograph
You find simplified version here Aqupla
