Argatroban Nichi-iko

Argatroban Nichi-iko Uses, Dosage, Side Effects, Food Interaction and all others data.

Argatroban Nichi-iko is a direct, selective thrombin inhibitor. The American College of Cardiologists (ACC) recommend using bivalirudin or argatroban in patients who have had, or at risk for, heparin induced thrombocytopenia (HIT) and are undergoing percutaneous coronary intervention. Argatroban Nichi-iko is a non-heparin anticoagulant shown to both normalize platelet count in patients with HIT and prevent the formation of thrombi. Parental anticoagulants must be stopped and a baseline activated partial thromboplastin time must be obtained prior to administering argatroban.

Argatroban Nichi-iko is a synthetic direct thrombin inhibitor derived from L-arginine indicated as an anticoagulant for prophylaxis or treatment of thrombosis in patients with heparin-induced thrombocytopenia. Argatroban Nichi-iko is a direct thrombin inhibitor that reversibly binds to the thrombin active site. Argatroban Nichi-iko does not require the co-factor antithrombin III for antithrombotic activity. Argatroban Nichi-iko exerts its anticoagulant effects by inhibiting thrombin-catalyzed or -induced reactions, including fibrin formation; activation of coagulation factors V, VIII, and XIII; protein C; and platelet aggregation. Argatroban Nichi-iko is highly selective for thrombin with an inhibitory constant (Ki) of 0.04 µM. At therapeutic concentrations, Argatroban Nichi-iko has little or no effect on related serine proteases (trypsin, factor Xa, plasmin, and kallikrein).Argatroban Nichi-iko is capable of inhibiting the action of both free and clot-associated thrombin.

Trade Name Argatroban Nichi-iko
Availability Prescription only
Generic Argatroban
Argatroban Other Names Argatroban
Related Drugs warfarin, Coumadin, heparin, alteplase, Jantoven, streptokinase
Type
Formula C23H36N6O5S
Weight Average: 508.64
Monoisotopic: 508.246789457
Protein binding

54%

Groups Approved, Investigational
Therapeutic Class
Manufacturer
Available Country Japan
Last Updated: September 19, 2023 at 7:00 am
Argatroban Nichi-iko
Argatroban Nichi-iko

Uses

Argatroban Nichi-iko is a synthetic direct thrombin inhibitor used for the prevention and treatment of thrombosis related to heparin use.

Argatroban Nichi-iko is indicated for prevention and treatment of thrombosis caused by heparin-induced thrombocytopenia (HIT). It is also indicated for use in patients with, or at risk for, HIT who are undergoing percutaneous coronary intervention.

Argatroban Nichi-iko is also used to associated treatment for these conditions: Thrombotic events

How Argatroban Nichi-iko works

Argatroban Nichi-iko exerts its anticoagulant effects by inhibiting thrombin-catalyzed or -induced reactions, including fibrin formation; activation of coagulation factors V, VIII, and XIII; protein C; and platelet aggregation.

Toxicity

Excessive bleeding

Food Interaction

  • Avoid herbs and supplements with anticoagulant/antiplatelet activity. Examples include garlic, ginger, bilberry, danshen, piracetam, and ginkgo biloba.
  • Exercise caution with grapefruit products. Grapefruit inhibits CYP3A4 metabolism, which may increase the serum concentration of argatroban; however, the evidence is conflicting.
  • Exercise caution with St. John's Wort.

Argatroban Nichi-iko Disease Interaction

Major: active bleeding

Volume of Distribution

  • 174 mL/kg
  • 12.18 L [70-kg adult]

Elimination Route

Bioavailability is 100% (intravenous).

Half Life

39 and 51 minutes

Clearance

  • 5.1 L/kg/hr [infusion doses up to 40 mcg/kg/min]

Elimination Route

Argatroban Nichi-iko is excreted primarily in the feces (65%), presumably through biliary secretion; 22% is eliminated via urine.

Innovators Monograph

You find simplified version here Argatroban Nichi-iko

*** Taking medicines without doctor's advice can cause long-term problems.
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