Aristopyrin

Aristopyrin Uses, Dosage, Side Effects, Food Interaction and all others data.

A drug that has anti-inflammatory, antipyretic, and analgesic activities. It is especially effective in the treatment of ankylosing spondylitis. It also is useful in rheumatoid arthritis and Reiter's syndrome (investigational indication). Although phenylbutazone is effective in gouty arthritis, risk/benefit considerations indicate that this drug should not be employed for this disease. (From AMA Drug Evaluations Annual, 1994, p1822)

Phenylbutazone is a synthetic, pyrazolone derivative. It is a nonhormonal anti-inflammatory, antipyretic compound useful in the management of inflammatory conditions. The apparent analgesic effect is probably related mainly to the compound's anti-inflammatory properties and arise from its ability to reduce production of prostaglandin H and prostacyclin. Prostaglandins act on a variety of cells such as vascular smooth muscle cells causing constriction or dilation, on platelets causing aggregation or disaggregation and on spinal neurons causing pain. Prostacylcin causes vascular constriction platelet disaggregation

Table Of contents

• Aristopyrin
• Uses
• Dosage
• Side Effect
• Precautions
• Interactions
• Uses during Pregnancy
• Uses during Breastfeeding
• Accute Overdose
• Food Interaction
• Half Life
• Volume of Distribution
• Clearance
• Interaction With other Medicine
• Contradiction
• Storage

Trade Name	Aristopyrin
Generic	Phenylbutazone + Paracetamol / Acetaminophen + Propyphenazone
Weight	125mg
Type	Tablet
Therapeutic Class
Manufacturer	Aristo Pharmaceuticals Pvt Ltd
Available Country	India
Last Updated:	September 19, 2023 at 7:00 am

Uses

Phenylbutazone is an NSAID used to treat backache and ankylosing spondylitis.

For the treatment of backache and ankylosing spondylitis

Aristopyrin is also used to associated treatment for these conditions: Inflammation, Pain, Arthritic painHeadache, Pain, Pain, Menstrual, Rheumatism, Rheumatism, Muscular, Toothache, Mild to moderate pain

How Aristopyrin works

Phenylbutazone binds to and inactivates prostaglandin H synthase and prostacyclin synthase through peroxide (H2O2) mediated deactivation. The reduced production of prostaglandin leads to reduced inflammation of the surrounding tissues.

Toxicity

Oral, LD₅₀ = 238 mg/kg (mouse); Oral, LD₅₀ = 781 mg/kg (rabbit); Oral, LD₅₀ = 245 mg/kg (rat); Oral, LD₅₀ = 375 mg/kg (rat)

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