Arsenic Trioxide

Arsenic Trioxide Uses, Dosage, Side Effects, Food Interaction and all others data.

Arsenic Trioxide is a chemotherapeutic agent of idiopathic function used to treat leukemia that is unresponsive to first line agents. It is suspected that arsenic trisulfide induces cancer cells to undergo apoptosis. In general, arsenic is known to be a naturally toxic substance capable of eliciting a variety of dangerous adverse effects. The enzyme thioredoxin reductase has recently been identified as a target for arsenic trioxide.

Arsenic Trioxide is indicated for induction of remission and consolidation in patients with acute promyelocytic leukemia (APL) who are refractory to, or have relapsed from, retinoid and anthracycline chemotherapy.

Arsenic Trioxide
Uses
Dosage
Side Effect
Precautions
Interactions
Uses during Pregnancy
Uses during Breastfeeding
Accute Overdose
Food Interaction
Half Life
Volume of Distribution
Clearance
Interaction With other Medicine
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Trade Name	Arsenic Trioxide
Generic	Arsenic trioxide
Arsenic trioxide Other Names	Acide Arsenieux, Anhydride Arsenieux, Arsenic Blanc, Arsenic oxide, Arsenic trioxide, Arsenic(III) oxide, arsénico trióxido, Arsenigen Saure, Arsenolite, Arsenous oxide, Arsenous oxide anhydride, Diarsenic oxide, Diarsenic trioxide, White arsenic
Weight	1mg/ml, 2mg/ml,
Type	Infusion, Intravenous Solution, Intravenous
Formula	As₂O₃
Weight	Average: 197.84 Monoisotopic: 197.827934
Protein binding	75% bound
Groups	Approved, Investigational
Therapeutic Class
Manufacturer	Thornton & Ross Ltd
Available Country	United Kingdom, United States
Last Updated:	September 19, 2023 at 7:00 am

Uses

Arsenic Trioxide is a chemotherapeutic agent used in the treatment of refractory or relapsed acute promyelocytic leukemia in patients with prior retinoid and anthracycline chemotherapy.

For induction of remission and consolidation in patients with acute promyelocytic leukemia (APL), and whose APL is characterized by the presence of the t(15;17) translocation or PML/RAR-alpha gene expression

Arsenic Trioxide is also used to associated treatment for these conditions: Refractory Acute Promyelocytic Leukemia

How Arsenic Trioxide works

The mechanism of action of Arsenic Trioxide is not completely understood. Arsenic Trioxide causes morphological changes and DNA fragmentation characteristic of apoptosis in NB4 human promyelocytic leukemia cells in vitro. Arsenic Trioxide also causes damage or degradation of the fusion protein PML/RAR-alpha. It is suspected that arsenic trioxide induces cancer cells to undergo apoptosis.