Artoflex Tablet 300 mg
Artoflex Tablet 300 mg Uses, Dosage, Side Effects, Food Interaction and all others data.
Artoflex Tablet 300 mg possesses analgesic and anti-inflammatory properties. Its mode of action, like that of other nonsteroidal anti-inflammatory agents, is not completely understood, but may be related to prostaglandin synthesis inhibition.
Like common NSAIDs, dexibuprofen is an active enantiomer of ibuprofen that suppresses the prostanoid synthesis in the inflammatory cells via inhibition of the COX-2 isoform of the arachidonic acid COX. Attenuating the synthesis of prostaglandins and thromboxanes gives the drug three major therapeutic actions. Anti-inflammatory action comes from decreased prostaglandin E2 and prostacyclin leading to decreased vasodilation and oedema that enhances vascular permeability and activity of inflammatory mediators. Decreased prostaglandin levels in the hypothalamus confers the antipyretic effect of the drug. Analgesic effect stems from decreased prostaglandin levels that sensitize the nociceptors to inflammatory mediators at sites of pain and enhance transmission from afferent pain fibers at the spinal cord
For more information, refer to ibuprofen.
Trade Name | Artoflex Tablet 300 mg |
Generic | Dexibuprofen |
Dexibuprofen Other Names | d-ibuproten, Dexibuprofen, Dexibuprofeno |
Weight | 300 mg |
Type | Tablet |
Formula | C13H18O2 |
Weight | Average: 206.2808 Monoisotopic: 206.13067982 |
Protein binding | For more information, refer to ibuprofen. |
Groups | Approved, Investigational |
Therapeutic Class | Drugs for Osteoarthritis, Drugs used for Rheumatoid Arthritis, Non-steroidal Anti-inflammatory Drugs (NSAIDs) |
Manufacturer | Opsonin Pharma Ltd. |
Available Country | Bangladesh |
Last Updated: | October 19, 2023 at 6:27 am |
![Artoflex Tablet 300 mg Artoflex Tablet 300 mg](https://www.medicinesfaq.com/media/png/artoflex-tablet.png)
Uses
Artoflex Tablet 300 mg is used for:
- Pain and inflammation associated with osteoarthritis, rheumatoid arthritis & other musculoskeletal disorders
- Mild to moderate pain and inflammation including dysmenorrhoea, dental pain
- Pyrexia of unknown origin
- Headache
Artoflex Tablet 300 mg is also used to associated treatment for these conditions: Fever, Inflammation, Pain, Spasms, Analgesia
How Artoflex Tablet 300 mg works
Like common NSAIDs, dexibuprofen is an active enantiomer of ibuprofen that suppresses the prostanoid synthesis in the inflammatory cells via inhibition of the COX-2 isoform of the arachidonic acid COX. For more information, refer to ibuprofen.
Dosage
Artoflex Tablet 300 mg dosage
The recommended dosage of dexibuprofen is 600 to 900 mg/day, at 2-3 divided doses. Maximum single dose is 400 mg. The dosage can be raised temporarily up to 1200 mg/day in patients with acute disorders or exacerbations.
Side Effects
The most common side effects are nausea, vomiting and abdominal pain. Besides these fatigue, drowsiness, headache, dizziness, vertigo, rash, peripheral odema may also occur. Bleeding time may be prolonged.
Toxicity
Oral LD50 value in rats is 636 mg/kg. For more information, refer to ibuprofen.
Precaution
Artoflex Tablet 300 mg should be used with caution in patients with active and suspected gastrointestinal bleeding and bronchial asthma. In heart failure, hypertension, renal or hepatic disease, especially during concomitant diuretic treatment, the risk of fluid retention and deterioration in renal function should be taken into account. In case of elderly patient dexibuprofen should be started with lower dose. In case of hepatic and renal dysfunction it should be started with lower dose. It should not be used in patient with severe hepatic and renal dysfunction.
Interaction
Drug interactions is noticed with concomitant use of anticoagulant, methotrexate, lithium, corticosteroids, phenytoin, thiazides and thiazide related substances, other NSAIDs and salicylates, digoxin, ciclosporin, tacrolimus, beta blockers and ACE inhibitors.
Volume of Distribution
For more information, refer to ibuprofen.
Elimination Route
The time it take to reach peak plasma concentration is 2.25-5 hours post-administration of oral tablets containing 300mg of dexibuprofen. For more information, refer to ibuprofen.
Half Life
Oral tablets containing 300mg of dexibuprofen results in 2.2-4.7 hours . For more information, refer to ibuprofen.
Clearance
For more information, refer to ibuprofen.
Elimination Route
Mainly renal excretion. For more information, refer to ibuprofen.
Pregnancy & Breastfeeding use
Pregnancy: no clinical data on exposed pregnancies are available.
Lactation: Ibuprofen is slightly excreted in human milk. Breast-feeding is possible with dexibuprofen if dosage is low and the treatment period is short.
Contraindication
Artoflex Tablet 300 mg is contraindicated in patients with known hypersensitivity to any ingredient of Artoflex Tablet 300 mg or individuals with acute rhinitis, nasal polyps, urticaria or angioneurotic oedema, gastrointestinal ulcer or bleeding.
Special Warning
Children: As the molecule's safety and efficacy has not been established in patients under 18 years of age, it cannot be recommended in this age group.
Elderly patient: Lowest effective dose is recommended. The dosage can be raised to adult dosage if well tolerated.
Hepatic impairment patient: Patients with mild to moderate liver function impairments must start with low amounts, and must closely be monitored. Artoflex Tablet 300 mg should not be used in patients with serious liver function impairment.
Renal impairment patient: The starting amount must be reduced to patients with mild to moderate kidney function impairments. Artoflex Tablet 300 mg should not be used patients with serious kidney function impairments.
Acute Overdose
Artoflex Tablet 300 mg has a low acute toxicity and patients have survived after single dose as high as 54 g of racemic ibuprofen. Mild symptoms are most common including abdominal pain, nausea, vomiting, lethargy, drowsiness, headache, titinus, nystagmus and ataxia. The onset of symptoms usually occurs within 4 hours. Treatment is symptomatic and there is no specific antidote.
Storage Condition
Store in a cool & dry place protected from light and moisture. Keep out of reach of children.
Innovators Monograph
You find simplified version here Artoflex Tablet 300 mg
Artoflex Tablet 300 mg contains Dexibuprofen see full prescribing information from innovator Artoflex Tablet 300 mg Monograph, Artoflex Tablet 300 mg MSDS, Artoflex Tablet 300 mg FDA label