Artroda Myungmoon
Artroda Myungmoon Uses, Dosage, Side Effects, Food Interaction and all others data.
Artroda Myungmoon is a prodrug which is metabolized to rhein. It is currently approved in France for the treatment of osteoarthritis although the use of diacerein is restricted due to the side effects including severe diarrhea . Artroda Myungmoon is under investigation for the treatment of Insulin Resistance, Diabetes Mellitus (Type 2), and Diabetes-Related Complications.
Decreases inflammation and cartilage destruction and also corrects altered osteoblast acitivity .
| Trade Name | Artroda Myungmoon |
| Generic | Diacerein |
| Diacerein Other Names | Diacerein, Diacereína |
| Type | |
| Formula | C19H12O8 |
| Weight | Average: 368.297 Monoisotopic: 368.053217346 |
| Protein binding | 99% of rhein is bound to plasma proteins . |
| Groups | Approved, Investigational |
| Therapeutic Class | |
| Manufacturer | |
| Available Country | South Korea |
| Last Updated: | September 19, 2023 at 7:00 am |
Uses
Artroda Myungmoon is an slow-onset anthraquinone IL-1 inhibitor used in the treatment of degenerative joint diseases like osteoarthritis.
For the treatment of osteoarthritis affecting the hip or knee .
Artroda Myungmoon is also used to associated treatment for these conditions: Osteoarthritis in the Hip Joint, Osteoarthritis of the Knee
How Artroda Myungmoon works
Artroda Myungmoon's active metabolite rhein Rhein reduces cartilage destruction by decreasing expression of matrix metalloproteinase (MMP)-1 and -3 as well as upregulating tissue inhibitor of matrix metalloproteinases which serve to reduce the activity of several MMPs . The anti-inflammatory action of rhein reduces the level of interleukin-1beta activity which plays a large role in reduction of extracellular matrix production, MMP activity, and continued inflammation . Rhein reduces abnormal osteoblast synthetic activity through an unknown mechanism .
Toxicity
Rhein Rhein has an oral LD50 of >5000mg/kg in mice. This is equivalent to a diacerein dose of >6476mg/kg.
Volume of Distribution
15-60L .
Elimination Route
Bioavailability of 50-60% . Entirely converted to the active metabolite rhein Rhein before reaching systemic circulation.
Half Life
4-10h .
Clearance
Total CL is 1.5L/h and renal CL is 0.1L/h .
Elimination Route
37% excreted in urine and 53% in feces as estimated in rats .
Innovators Monograph
You find simplified version here Artroda Myungmoon
FAQ
What is Artroda Myungmoon used for?
Artroda Myungmoon is a slow-acting medicine of the class anthraquinone used to treat joint diseases such as osteoarthritis.
How safe is Artroda Myungmoon?
Artroda Myungmoon is safe, apart from a substantially higher risk of diarrhoea, especially with longer-term use.Artroda Myungmoon has an acceptable safety profile, particularly in comparison with that of NSAIDs and paracetamol. The ESCEO positions Artroda Myungmoon as a first-line pharmacological background treatment of osteoarthritis.
How does Artroda Myungmoon work?
Artroda Myungmoon works by blocking the actions of interleukin-1 beta, a protein involved in the inflammation and destruction of cartilage that plays a role in the development of symptoms of degenerative joint diseases such as osteoarthritis.
What are the common side effects of Artroda Myungmoon?
Common side effects of Artroda Myungmoon are include:
- Diarrhoea.
- Stomach discomfort and pain.
- Nausea.
- Vomiting.
- Yellowing of skin and eyes.
- Urine discoloration.
- Increase in liver enzyme levels.
- Allergic skin reaction.
Is Artroda Myungmoon safe during pregnancy?
Artroda Myungmoon should not be administered during pregnancy.
Is Artroda Myungmoon safe during breastfeeding?
Artroda Myungmoon should not be administered during lactation.
Can I drink alcohol with Artroda Myungmoon?
Patients should be advised to limit their alcohol intake while on treatment with Artroda Myungmoon.
Can I drive after taking Artroda Myungmoon?
Artroda Myungmoon may cause dizziness and drowsiness. So if you observe such symptoms, then do not drive.
When should be taken of Artroda Myungmoon?
The recommended starting dose is 50 mg once daily with evening meal for the first 2 to 4 weeks of treatment, after which the recommended daily dose is 50 mg twice daily.
Can I take Artroda Myungmoon on an empty stomach?
The Artroda Myungmoon should be taken with food, one with breakfast and the other with evening meal.
How often can I take Artroda Myungmoon?
The recommended dose is 50 mg to be taken twice daily.
How long does Artroda Myungmoon take to work ?
Artroda Myungmoon starts showing its action in 2-3 hours. The duration of action of Artroda Myungmoon is 27 hours
How long can Artroda Myungmoon be taken?
The duration of action of Artroda Myungmoon is 27 hours.
Who should not take Artroda Myungmoon?
Artroda Myungmoon should not be used in any patient with liver disease or a history of liver disease, and doctors should be monitoring their patients for early signs of liver problems.
Is Artroda Myungmoon an antibiotic?
Artroda Myungmoon is a novel antibacterial agent; the antibacterial breakpoint could not be found in the literature or in standards.
What happen If I missed a dose of Artroda Myungmoon?
If you forget to take a dose of Artroda Myungmoon, make sure that you remember to take your next dose when it is due. Do not take two doses together to make up for a missed dose.
What happen if I overdose on Artroda Myungmoon?
Never take more than the prescribed dose. Seek emergency medical treatment or contact the doctor if you suspect that you might have taken an overdose of Artroda Myungmoon.
Can Artroda Myungmoon causes diarrhoea?
Artroda Myungmoon may cause diarrhoea or loose stools in the first few days of treatment. Contact your doctor if the diarrhoea does not stop within 3-4 days.
Who should not take Artroda Myungmoon?
Avoid taking Artroda Myungmoon if you are allergic to it. Seek medical attention if you notice any allergic reactions such as skin rash, hives (painful, itchy eruptions that sting), swelling (face, lips, tongue, etc.), breathing difficulty, etc. Artroda Myungmoon is excreted through the kidneys.
If you have pre-existing kidney problems, this medicine may accumulate in your kidneys and further worsen your condition. Hence, this medicine is not recommended for use if you have kidney problems.
Can Artroda Myungmoon affects my heart ?
Artroda Myungmoon Improves Left Ventricular Remodeling and Cardiac Function by Reducing the Inflammatory Response after Myocardial Infarction.
Does Artroda Myungmoon cause kidney damage?
Artroda Myungmoon has shown to be safe and effective in patients with moderate to severe renal impairment, and dose adjustment is not required in these patients.
Can Artroda Myungmoon affects my liver?
Around 0.5% of patients on Artroda Myungmoon had some kind of liver reaction, with most cases being mild, reversible increases in serum transaminases.
