Aspartylphenylalanine Methyl Ester

Aspartylphenylalanine Methyl Ester Uses, Dosage, Side Effects, Food Interaction and all others data.

Aspartylphenylalanine Methyl Ester is a low-calorie sweetener used to sweeten a wide variety of low- and reduced-calorie foods and beverages, including low-calorie tabletop sweeteners. Aspartylphenylalanine Methyl Ester is composed of two amino acids, aspartic acid and phenylalanine, as the methyl ester. Aspartic acid and phenylalanine are also found naturally in protein containing foods, including meats, grains and dairy products. Methyl esters are also found naturally in many foods such as fruits and vegetable and their juices. Upon digestion, aspartame breaks down into three components (aspartic acid, phenylalanine and methanol), which are then absorbed into the blood and used in normal body processes. Neither aspartame nor its components accumulates in the body. These components are used in the body in the same ways as when they are derived from common foods.Aspartylphenylalanine Methyl Ester is 180 to 200 times sweeter than sucrose, it is metabolized as a protein and its subsequent amino-acids used up in there respective mechanisms.

Aspartylphenylalanine Methyl Ester (L-alpha-aspartyl-L-phenylalanine methyl ester) is a low-calorie sweetener used to sweeten a wide variety of low- and reduced-calorie foods and beverages, including low-calorie tabletop sweeteners. Aspartylphenylalanine Methyl Ester is composed of two amino acids, aspartic acid and phenylalanine, as the methyl ester. Aspartic acid and phenylalanine are also found naturally in protein containing foods, including meats, grains and dairy products. Methyl esters are also found naturally in many foods such as fruits and vegetable and their juices. Upon digestion, aspartame breaks down into three components (aspartic acid, phenylalanine and methanol), which are then absorbed into the blood and used in normal body processes. Neither aspartame nor its components accumulates in the body. These components are used in the body in the same ways as when they are derived from common foods.

Aspartylphenylalanine Methyl Ester
Uses
Dosage
Side Effect
Precautions
Interactions
Uses during Pregnancy
Uses during Breastfeeding
Accute Overdose
Food Interaction
Half Life
Volume of Distribution
Clearance
Interaction With other Medicine
Contradiction
Storage

Trade Name	Aspartylphenylalanine Methyl Ester
Generic	Aspartame
Aspartame Other Names	Asp-phe-ome, Aspartam, Aspartame, Aspartamo, Aspartamum, Aspartylphenylalanine methyl ester
Type
Formula	C₁₄H₁₈N₂O₅
Weight	Average: 294.3031 Monoisotopic: 294.121571696
Groups	Investigational, Nutraceutical
Therapeutic Class	Oral nutritional preparations
Manufacturer
Available Country
Last Updated:	September 19, 2023 at 7:00 am

Uses

Used as a diet supplement and sugar substitute.

Aspartylphenylalanine Methyl Ester is also used to associated treatment for these conditions: Sweeteners

How Aspartylphenylalanine Methyl Ester works

180 to 200 times sweeter than sucrose, it is metabolized as a protein and its subsequent amino-acids used up in there respective mechanisms.

Dosage

Aspartylphenylalanine Methyl Ester dosage

According to individual taste. 1 pellet is equivalent in sweetness to 1 tsf of sugar.

Side Effects

Constipation; faecal impaction; haemorrhoids; abdominal discomfort or pain; heartburn; flatulence; nausea; vomiting; diarrhoea; increased bleeding tendency (chronic use); osteoporosis; steatorrhoea (high doses); skin rashes; pruritus of the tongue, skin and perianal region; hyperchloraemic acidosis.

Toxicity

Mild gastrointestinal side effects including diarrhea have been reported.

Precaution

If pregnant or breast-feeding, seek advice of a health professional before use.

Interaction

There are no known drug interactions and none well documented.

Elimination Route

Absorbed in the small intestine, aspartame is metabolized and absorbed very quickly.

Half Life

At room temperature, aspartame is most stable at pH 4.3, where its half-life is nearly 300 days. At pH 7, its half-life is shortened to only a few days.

Pregnancy & Breastfeeding use

Pregnancy Category-C. Animal reproduction studies have shown an adverse effect on the fetus and there are no adequate and well-controlled studies in humans, but potential benefits may warrant use of the drug in pregnant women despite potential risks.