Atagip
Atagip Uses, Dosage, Side Effects, Food Interaction and all others data.
Attapulgite is a magnesium aluminium phyllosilicate which occurs in a type of clay soil common to the Southeastern United States. When used in medicine, it physically binds to acids and toxic substances in the stomach and digestive tract. For that reason, it has often been used in antidiarrheal medications. Until 2003, it was the active ingredient used in Kaopectate, before that product was reformulated with bismuth subsalicylate.
Attapulgite is an adsorptive magnesium aluminium phyllosilicate which binds to toxins, bacteria and water.
Pectin is a heteropolysaccharide commercially derived from the cell wall of higher plants. It is composed of partially methylated polygalacturonic acid units linked in the positions 1-4. The carboxylic group of the constituents of pectin can exist in the form of esters, free acids, ammonium, potassium or sodium salts or as acid amides. Under the FDA regulation, pectin qualifies as a GRAS (generally recognized as safe) food substance. This status allows pectin to be used with no limitations.
Pectin increases viscosity and volume of stools which helps it to be used for constipation and diarrhea. It is reported as well to present lowering effects of different body components. This effect depends on the type of pectin which indicated that this effect is related to the composition of the correspondent pectin. Nonetheless, this data is still unclear and more studies need to be performed to conclude this effect of pectin.
| Trade Name | Atagip |
| Generic | Attapulgite + Pectin |
| Weight | 600mg, 50mg |
| Type | Tablet |
| Therapeutic Class | |
| Manufacturer | PT First Medifarma |
| Available Country | Indonesia |
| Last Updated: | September 19, 2023 at 7:00 am |
Uses
Attapulgite is a veterinary antidiarrheal agent used to treat non-infectious diarrhea in animals.
When used in medicine, it physically binds to acids and toxic substances in the stomach and digestive tract. For that reason, it has often been used in antidiarrheal medications. Attapulgite is an adsorbent.
Pectin is used in food as a gelling agent and stabilizer. As a medical drug, it has obtained a great interest in its potential use as a source of dietary fiber, lipid, cholesterol, serum glucose and insulin level lowering effect, gastric emptying delay. Some recent studies have researched the possibility of using pectin for the formation of nanoparticles as a delivery vehicle of drugs.
Atagip is also used to associated treatment for these conditions: Acute Diarrhoea, DiarrhoeaBacterial diarrhoea, Diarrhea caused by Salmonella, Diarrhea caused by Shigella, Diarrhea caused by Staphylococcus, Escherichia Coli Diarrhea, Sore Throat, Mouth soreness
How Atagip works
Attapulgite adsorbs water, toxins and bacteria, contributing to firmer stools, reducing fluid loss from diarrhea.
Pectin is an adsorbent that binds to bacteria, toxins and other irritants in the intestinal mucosa. Pectin is able to decrease the pH in the intestinal lumen and provides a soothing effect on the irritated mucosa.
Toxicity
Pectin is a substance determined to be safe.
Volume of Distribution
Pharmacokinetic studies have not been performed as pectin is not absorbed.
Elimination Route
Pectin is not absorbed and it is not distributed in the body.
Half Life
Pharmacokinetic studies have not been performed as pectin is not absorbed.
Clearance
Pharmacokinetic studies have not been performed as pectin is not absorbed.
Elimination Route
Pectin is completely excreted in the feces, including a small amount of trigalacturonic acid that can be found in the colon.
Innovators Monograph
You find simplified version here Atagip
