Atcine

Atcine Uses, Dosage, Side Effects, Food Interaction and all others data.

Atcine is a tetracycline derivative which blocks the access of bacterial aminoacyl-tRNA to the mRNA-ribosome complex by binding to the 30S ribosome subunit, preventing the addition of amino acids to the growing peptide chain in protein synthesis

Atcine, like other tetracyclines, exerts bacteriostatic actions on intracellular and extracellular bacteria, treating susceptible bacterial infections. It has been shown to be safe and effective in the treatment of moderate to severe acne.

It is important to note that like other tetracyclines, lymecycline may cause esophageal irritation and ulceration, which can be prevented by drinking adequate fluids during administration. It also has the potential to cause photosensitivity. Atcine can lead to renal tubular acidosis or hepatic toxicity. It is not recommended to administer this drug in patients with renal disease or severe hepatic disease.

Atcine
Uses
Dosage
Side Effect
Precautions
Interactions
Uses during Pregnancy
Uses during Breastfeeding
Accute Overdose
Food Interaction
Half Life
Volume of Distribution
Clearance
Interaction With other Medicine
Contradiction
Storage

Trade Name	Atcine
Generic	Lymecycline
Lymecycline Other Names	Limeciclina, Lymecycline, Lymecyclinum, N-Lysinomethyltetracycline
Weight	408mg
Type	Capsule
Formula	C₂₉H₃₈N₄O₁₀
Weight	Average: 602.6328 Monoisotopic: 602.258793456
Groups	Approved, Investigational
Therapeutic Class	Tetracycline Group of drugs
Manufacturer	Atco Laboratories Limited
Available Country	Pakistan
Last Updated:	September 19, 2023 at 7:00 am

Uses

Atcine capsules belong to a group of medicines called tetracycline antibiotics. It is used to treat acne which appears as blackheads or whiteheads, which people often refer to as pimples or spots.This medicine can also be used to treat other infections, such as:

Acute sinusitis
Bronchitis
Infections in the abdomen
Some types of eye infections called trachoma
Soft skin infections

Atcine is also used to associated treatment for these conditions: Acne Vulgaris, Susceptible Bacterial Infections

How Atcine works

Normally, the ribosome synthesizes proteins through the binding of aminoacyl-tRNA to the mRNA-ribosome complex. Atcine binds to the 30S ribosomal subunit, preventing amino-acyl tRNA from binding to the A site of the ribosome, which prevents the elongation of polypeptide chains. This results in bacteriostatic actions, treating various infections.

Dosage

Atcine dosage

Adults and children over 12 years:

Acne: the normal dose is one capsule once a day, preferably in the morning. Atcine capsules should always be taken with a glass of water. How long you will have to take Atcine capsules for will depend on how quickly your condition improves. For acne this will normally be a minimum of eight weeks.
Infections: For other infections the usual dose is one Atcine capsule twice a day. Your doctor may recommend a higher or lower dose; this depends upon the type and severity of the infection. Ask your doctor if you are unsure. Atcine capsules should always be taken with a glass of water.

Use in children and adolescents: Atcine capsules are not recommended for use in children under 12 years of age as they can cause permanent discolouration of tooth enamel and affect bone development.

Should be taken on an empty stomach. Take 1 hr before or 2 hr after meals.

Side Effects

Atcine capsules may also cause the followingside effects.

Common (occur in less than 1 in 10 patients):

Feeling sick (nausea)
Abdominal pain
Diarrhoea
Headache

Unknown (frequency cannot be estimated fromavailable information):

Eyesight disturbances
Dizziness
Being sick (vomiting)
Yellowing of eyes or skin (jaundice)
Increased sensitivity of the skin to sunlight (real or artificial)
Increased pressure in the brain
Changes in type or number of certain blood cells
Pain in the upper part of the abdomen
Changes in some blood tests (liver function tests)
Fever
Itchiness, skin rash, or hives
Inflammation of the intestine

Toxicity

The oral LD50 of lymecycline in rats is 3200 mg/kg. Overdoses with lymecycline are rare. In the case of an overdose, gastric lavage should be performed immediately. Provide supportive treatment and maintain fluid balance.

Precaution

Patient with myasthenia gravis. May exacerbate SLE. Hepatic impairment.

Interaction

Decreased absorption with Ca, Al, Mg, bismuth and zinc salts, antacids, bismuth containing ulcer-healing drugs, Fe preparations and quinapril. Increased effects of anticoagulants. Decreased plasma levels with barbiturates, phenytoin or carbamazepine.

Food Interaction

Take with or without food.

Volume of Distribution

Atcine is lipophilic and easily crosses the cell membrane and passively diffuses through bacterial porin channels. As a second-generation tetracycline, the concentration in the bile ranges from 10 to 25 times higher than plasma concentration. In general, the volume of distribution of tetracyclines ranges from 1.3–1.7 L/kg or 100–130 L.

Elimination Route

Atcine is 77-88% absorbed after oral administration with a relative bioavailability of 70%. The Cmax of lymecycline is 2.1 mg/L and is achieved about 3 hours after administration. The AUC is 21.9 ± 4.3 mg·h/L.

Half Life

The half-life of lymecycline is approximately 8 hours.

Clearance

Atcine is partially cleared by the kidneys, like other tetracyclines.

Elimination Route

Atcine is 25% eliminated in the urine. Based on being a member of the tetracycline drug class, fecal elimination is likely another route of elimination.

Pregnancy & Breastfeeding use

If you are pregnant or breast-feeding, think you may be pregnant or are planning to have a baby, ask your doctor or pharmacist for advice before taking this medicine. Atcine capsules must not to be taken if you are pregnant or breast feeding. Use of medicines such as Atcine capsules may affect the proper growth of developing teeth or bones, and lead to permanent tooth discolouration.

Contraindication

Hypersensitivity to lymecycline or other tetracyclines. Overt renal insufficiency. Pregnancy and lactation. Concomitant use with methoxuflurane or oral retinoids.