Atenativ

Atenativ Uses, Dosage, Side Effects, Food Interaction and all others data.

Antithrombin Alfa is a recombinant antithrombin , an anticoagulant, that is used for the prevention of thromboembolic events in patients that have hereditary deficiency of antithrombin in high risk situations.

Hereditary antithrombin deficiency causes an increased risk of venous thromboembolism (VTE). In high risk situations, such as surgery or trauma or for pregnant women during the peri-partum period, the risk of development of VTEs is 10-50 times greater than the general population. In hereditary antithrombin deficient patients antithrombin alfa normalizes plasma antthrombin activity levels during peri-operative and peri-partum periods.

Trade Name Atenativ
Generic Antithrombin Iii + Antithrombin Alfa
Type
Therapeutic Class
Manufacturer
Available Country Spain
Last Updated: September 19, 2023 at 7:00 am
Atenativ
Atenativ

Uses

Antithrombin Alfa is a recombinant antithrombin used to treat peri-operative and peripartum thromboembolic events in hereditary antithrombin deficiency.

Antithrombin alfa is a recombinant antithrombin it is indicated for the prevention of peri-operative and peri-partum thromboembolic events in patients with hereditary deficiency of antithrombin.

Atenativ is also used to associated treatment for these conditions: Postoperative Thromboembolism, Postpartum thrombosis

How Atenativ works

Antithrombin is the main inhibitor of thrombin and Factor Xa , the serine proteases involved in blood coagulation. Antithrombin neutralizes the activity of thrombin and Factor Xa by forming a complex which is rapidly removed from the circulation.

Toxicity

Highest dose tested was 360mg/kg/day in rats resulted in transient limb swelling.

Volume of Distribution

Dose of: 50IU/kg: 126.2 ml/kg 100IU/kg: 156.1 ml/kg Vd in hereditary deficient pregnant women in high risk situations had increased Vd of 14.3L.

Elimination Route

Given IV so not absorbed.

Half Life

Dose of: 50IU/kg: 11.6 h 100IU/kg: 17.7 h

Clearance

Dose of: 50IU/kg: 9.6 ml/hr/kg 100IU/kg: 7.2 ml/hr/kg Cl in hereditary deficient pregnant women in high risk situations had increased Cl of 1.38L/h.

Elimination Route

Irreversible complexes formed between antithrombin III and its target protease are rapidly removed by the liver.

Innovators Monograph

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*** Taking medicines without doctor's advice can cause long-term problems.
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