Atropan
Atropan Uses, Dosage, Side Effects, Food Interaction and all others data.
Atropan binds to and inhibit muscarinic acetylcholine receptors, producing a wide range of anticholinergic effects. Atropan is an anticholinergic agent which competitively blocks the muscarinic receptors in peripheral tissues such as the heart, intestines, bronchial muscles, iris and secretory glands. Some central stimulation may occur. Atropan abolishes bradycardia and reduces heart block due to vagal activity. Smooth muscles in the bronchi and gut are relaxed while glandular secretions are reduced. It also has mydriatic and cycloplegic effect.
Atropan, a naturally occurring belladonna alkaloid, is a racemic mixture of equal parts of d- and l-hyoscyamine, whose activity is due almost entirely to the levo isomer of the drug. Atropan is commonly classified as an anticholinergic or antiparasympathetic (parasympatholytic) drug. More precisely, however, it is termed an antimuscarinic agent since it antagonizes the muscarine-like actions of acetylcholine and other choline esters. Adequate doses of atropine abolish various types of reflex vagal cardiac slowing or asystole. The drug also prevents or abolishes bradycardia or asystole produced by injection of choline esters, anticholinesterase agents or other parasympathomimetic drugs, and cardiac arrest produced by stimulation of the vagus. Atropan may also lessen the degree of partial heart block when vagal activity is an etiologic factor. Atropan in clinical doses counteracts the peripheral dilatation and abrupt decrease in blood pressure produced by choline esters. However, when given by itself, atropine does not exert a striking or uniform effect on blood vessels or blood pressure.
Trade Name | Atropan |
Availability | Prescription only |
Generic | Atropine |
Atropine Other Names | Atropin, Atropina, Atropine, Atropinum, dl-Hyoscyamine, dl-tropyltropate, Tropine tropate |
Related Drugs | epinephrine, Adrenalin, isoproterenol, AtroPen, Isuprel, pralidoxime, tropicamide ophthalmic, DuoDote, Adrenaclick |
Type | Ampule |
Formula | C17H23NO3 |
Weight | Average: 289.3694 Monoisotopic: 289.167793607 |
Protein binding | The protein binding of atropine is 14 to 22% in plasma. |
Groups | Approved, Vet approved |
Therapeutic Class | Anticholinergics (antimuscarinics)/ Anti-spasmodics, Mydriatic and Cycloplegic agents |
Manufacturer | Zhejiang ruixin |
Available Country | Philippines |
Last Updated: | September 19, 2023 at 7:00 am |
Uses
Atropan is used for Non ulcer dyspepsia, Irritable bowel syndrome, Diverticular disease, Bradycardia, Organophosphorus poisoning, Premedication in anesthesia, Poisoning or overdosage with compound having muscarinic actions, Ophthalmic Inflammatory eye disorders, Eye refraction.
Atropan is also used to associated treatment for these conditions: Amblyopia, Atrioventricular Heart Block, Bradycardia, Bronchospasm, Crying, Detrusor Hyperreflexia, Excessive bronchial secretion, Hypertonic uterine contraction, Hypertonicity of the small intestine, Ocular Inflammation, Parkinsonism, Peptic Ulcer, Poisoning by parasympathomimetics (cholinergics), Poisoning caused by mushrooms, Poisoning caused by organophosphate anticholinesterase nerve agents, Poisoning caused by organophosphorus pesticides, Pylorospasm, Rhinorrhoea, Sinus Bradycardia, Spasms, Toxic effect of organophosphate and carbamate, Hypermobility of the colon, Laughing, Muscarinic side effects
How Atropan works
Atropan binds to and inhibit muscarinic acetylcholine receptors, producing a wide range of anticholinergic effects.
Dosage
Atropan dosage
Adult:
- IV: Bradycardia: 500 mcg every 3-5 mins. Total: 3 mg.
- IV/IM: Organophosphorus poisoning: 2 mg every 10-30 mins until muscarinic effects disappear or atropine toxicity appears.
- IM/SC: Premedication in anesthesia: 300-600 mcg 30-60 mins before anesthesia.
- IV/IM/SC: Poisoning or overdosage with compound having muscarinic actions: 0.6-1 mg, repeat 2 hrly.
- Ophthalmic: Inflammatory eye disorders: As 0.5-1% solution: 1-2 drops 4 times/day.
- Ophthalmic: refraction: 1% solution 1 drop twice daily for 1-2 days before procedure.
- Oral: Non ulcer dyspepsia, Irritable bowel syndrome, Diverticular disease: 0.6-1.2 mg as a single dose at bedtime.
Usual Pediatric Dose for Anesthesia:
- 7 to 16 pounds: 0.1 mg, IV, IM, or subcutaneously
- 17 to 24 pounds: 0.15 mg, IV, IM, or subcutaneously
- 24 to 40 pounds: 0.2 mg, IV, IM, or subcutaneously
- 40 to 65 pounds: 0.3 mg, IV, IM, or subcutaneously
- 65 to 90 pounds: 0.4 mg, IV, IM, or subcutaneously
- Over 90 pounds: 0.4 to 0.6 mg, IV, IM, or subcutaneously
Side Effects
Injection: Dry mouth, dysphagia, constipation, flushing and dryness of skin, tachycardia, palpitations, arrhythmias, mydriasis, photophobia, cycloplegia, raised intraocular pressure. Toxic doses cause tachycardia, hyperpyrexia, restlessness, confusion, excitement, hallucinations, delirium and may progress to circulatory failure and resp depression.
Eye drops or ointment: Systemic toxicity esp in children, on prolonged use may lead to irritation, hyperaemia, oedema and conjunctivitis. Increased intraocular pressure.
Toxicity
Oral, mouse: LD50 = 75 mg/kg. Symptoms of overdose includes widespread paralysis of parasympathetically innervated organs. Dry mucous membranes, widely dilated and nonresponsive pupils, tachycardia, fever and cutaneous flush are especially prominent, as are mental and neurological symptoms. In instances of severe intoxication, respiratory depression, coma, circulatory collapse and death may occur.
Precaution
Reflux oesophagitis; elderly; infants and children; Pregnancy.
Interaction
Additive anticholinergic effects with quinidine, antidepressants and some antihistamines.
Food Interaction
- Avoid alcohol.
- Take with food.
Atropan Alcohol interaction
[Moderate] GENERALLY AVOID:
Use of anticholinergic agents with alcohol may result in sufficient impairment of attention so as to render driving and operating machinery more hazardous.
In addition, the potential for abuse may be increased with the combination.
The mechanism of interaction is not established but may involve additive depressant effects on the central nervous system.
No effect of oral propantheline or atropine on blood alcohol levels was observed in healthy volunteers when administered before ingestion of a standard ethanol load.
However, one study found impairment of attention in subjects given atropine 0.5 mg or glycopyrrolate 1 mg in combination with alcohol.
Alcohol should generally be avoided during therapy with anticholinergic agents.
Patients should be counseled to avoid activities requiring mental alertness until they know how these agents affect them.
Atropan Hypertension interaction
[Minor] Cardiovascular effects of anticholinergics may exacerbate hypertension.
Therapy with anticholinergic agents should be administered cautiously in patients with hypertension.
Atropan Drug Interaction
Moderate: diphenhydramine, diphenhydramineMinor: acetaminophen, acetaminophen, acetaminophen, acetaminophenUnknown: aspirin, aspirin, epinephrine, epinephrine, lorazepam, lorazepam, glucose, glucose, furosemide, furosemide, midazolam, midazolam, ondansetron, ondansetron
Atropan Disease Interaction
Major: autonomic neuropathy, GI obstruction, glaucoma, obstructive uropathy, reactive airway diseases, myasthenia gravis, infectious diarrheaModerate: cardiac disease, tachycardia, coronary artery disease, gastric ulcer, gastroesophageal reflux, ulcerative colitis, liver disease, renal failureMinor: hypertension, hyperthyroidism, diarrhea, fever
Elimination Route
Atropan is rapidly and well absorbed after intramuscular administration. Atropan disappears rapidly from the blood and is distributed throughout the various body tissues and fluids.
Half Life
3.0 ± 0.9 hours in adults. The half-life of atropine is slightly shorter (approximately 20 minutes) in females than males.
Elimination Route
Much of the drug is destroyed by enzymatic hydrolysis, particularly in the liver; from 13 to 50% is excreted unchanged in the urine.
Pregnancy & Breastfeeding use
Pregnancy Category C. Animal reproduction studies have not been conducted with atropine. It also is not known whether atropine can cause fetal harm when given to a pregnant woman or can affect reproduction capacity. Atropan should be given to a pregnant woman only if clearly needed.
Contraindication
Glaucoma, chronic respiratory disease, sick sinus syndrome, thyrotoxicosis, cardiac failure, pyloric stenosis, prostatic hypertrophy.
Acute Overdose
May cause hyperthermia, hypertension, increased respiratory rate, nausea and vomiting. May also lead to CNS stimulation. Severe intoxication may lead to CNS depression, coma, respiratory failure and death.
Storage Condition
Store atropine at room temperature between 20 to 25° C. Store away from heat, moisture, and light. Keep atropine out of the reach of children.
Innovators Monograph
You find simplified version here Atropan
Atropan contains Atropine see full prescribing information from innovator Atropan Monograph, Atropan MSDS, Atropan FDA label