Auranofine

Uses

Auranofine is an antirheumatic used to treat active, progressive, or destructive forms of inflammatory arthritis.

Used in the treatment of active, progressive or destructive forms of inflammatory arthritis, such as adult rheumatoid arthritis.

Auranofine is also used to associated treatment for these conditions: Rheumatoid Arthritis

How Auranofine works

Inflammatory arthritis can cause joint swelling, warmth, pain, and tenderness; one cause of this condition is rheumatoid arthritis. In patients with rheumatoid arthritis, gold salts such as auranofin can be administered to decrease joint inflammation and prevent the destruction of bones and cartilage. Though the mechanism of action of auranofin is not fully established in rheumatoid arthritis, this drug has been shown to inhibit phagocytosis and the release of antibodies and enzymes that play a role in cytotoxic reactions, suppressing the inflammatory response.

Aside from its probable immune effects in inflammatory arthritis, studies have shown that auranofin inhibits thioredoxin reductase. This enzyme has various roles in cell homeostasis, including the regulation of free radicals. Thioredoxin reductase can be over expressed in various types of tumours, rendering it an attractive target for anticancer drug development. Studies have shown that inhibiting thioredoxin reductase can cause oxidative stress and apoptosis of tumour cells by increasing the formation of free radicals. Aurofin's thiol ligand binds with high affinity to thiol and selenol groups, forming irreversible reaction products. One study showed that treatment with auranofin increased the production or reactive oxygen species and caused elevation of intracellular calcium concentration in platelets, leading to cell death. Another study showed that auranofin enhanced the production of free radicals, governing T-cell activation.

Toxicity

Oral, rat: LD₅₀ = > 2000 mg/kg. Symptoms of overdose may include diarrhoea, vomiting, abdominal cramps, and symptoms of hypersensitivity (such as skin rash, hives, itching, and difficulty breathing).

Food Interaction

• Take with food. Food reduces irritation.

Auranofine Hypertension interaction

[Major] The use of gold compounds is contraindicated in patients with severe hypertension.

Prior to initiation of gold compounds medical problems that might affect the signs and symptoms used to detect gold compounds toxicity should be under control.

Auranofine Drug Interaction

Moderate: carboplatin, carboplatinUnknown: acetaminophen, acetaminophen, aspirin, aspirin, alprazolam, alprazolam, pseudoephedrine / triprolidine, pseudoephedrine / triprolidine, aspirin, aspirin, antipyrine / benzocaine otic, antipyrine / benzocaine otic, azithromycin, azithromycin, clonidine, clonidine, omega-3 polyunsaturated fatty acids, omega-3 polyunsaturated fatty acids

Auranofine Disease Interaction

Major: bone marrow aplasia, gold induced disorders, congestive heart failure, diabetes mellitus, liver disease, rash, renal dysfunction, severe hypertension, systemic lupus erythematosus

Elimination Route

Approximately 60% of the absorbed gold (15% of the administered dose) from a single dose of auranofin is excreted in urine; the remainder is excreted in the feces.

Innovators Monograph

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