Auroprozil
Auroprozil Uses, Dosage, Side Effects, Food Interaction and all others data.
Auroprozil is a semi synthetic, second generation cephalosporin antibiotic. Auroprozil is active in vitro against both gram positive and gram negative bacteria. The bactericidal activity of cefprozil results from the inhibition of cell wall synthesis via affinity for penicillin-binding proteins (PBPs).
Auroprozil inhibits bacterial cell wall synthesis by binding to 1 or more of the penicillin binding proteins (PBPs) which in turn inhibit the final transpeptidation step of peptidoglycan synthesis in bacterial cell walls, thus inhibiting cell wall biosynthesis and arresting cell wall assembly resulting in bacterial cell death.
Auroprozil, a semisynthetic, second-generation cephalosporin, is used to treat otitis media, soft-tissue infections, and respiratory tract infections.
| Trade Name | Auroprozil |
| Availability | Prescription only |
| Generic | Cefprozil |
| Cefprozil Other Names | Cefprozil, Cefprozilo, Cefprozilum |
| Related Drugs | amoxicillin, prednisone, doxycycline, ciprofloxacin, cephalexin, metronidazole, azithromycin, clindamycin, ceftriaxone, levofloxacin |
| Type | |
| Formula | C18H19N3O5S |
| Weight | Average: 389.426 Monoisotopic: 389.104541423 |
| Protein binding | 36% |
| Groups | Approved |
| Therapeutic Class | Second generation Cephalosporins |
| Manufacturer | |
| Available Country | South Africa |
| Last Updated: | September 19, 2023 at 7:00 am |
Uses
Auroprozil is used for the treatment of patients with mild to moderate infections caused by susceptible strains. Infections include:
- Lower respiratory tract infections: acute bronchitis, acute exacerbations of chronic bronchitis, community acquired pneumonia.
- Upper respiratory tract and ear infections: otitis media, sinusitis, tonsillitis and pharyngitis.
- Uncomplicated skin and soft tissue infections.
Auroprozil is also used to associated treatment for these conditions: Acute Bacterial Exacerbation of Chronic Bronchitis (ABECB), Bacterial Infections, Community Acquired Pneumonia (CAP), Streptococcal Pharyngitis, Streptococcal tonsillitis, Urinary Tract Infection, Bacterial otitis media, Uncomplicated skin and subcutaneous tissue bacterial infections
How Auroprozil works
Auroprozil, like the penicillins, is a beta-lactam antibiotic. By binding to specific penicillin-binding proteins (PBPs) located inside the bacterial cell wall, it inhibits the third and last stage of bacterial cell wall synthesis. Cell lysis is then mediated by bacterial cell wall autolytic enzymes such as autolysins; it is possible that cefprozil interferes with an autolysin inhibitor.
Dosage
Auroprozil dosage
Adult: 500 mg daily as a single or in 2 divided doses, increased to 500 mg bid if necessary. Duration: 10 days.Child (6 month to 2 year):
- For otitis media: 15 mg/kg 12 hrly.
- For acute sinusitis: 7.5 mg/kg or 15 mg/kg 12 hrly.
- For pharyngitis or tonsillitis: 7.5 mg/kg 12 hourly.
Child (>2 yr):
- For skin and skin structure infections: 20 mg/kg daily. Max: 1 g daily.
Side Effects
Auroprozil was usually well tolerated in controlled clinical trials. The most common adverse effects of cefprozil are diarrhea, nausea, vomiting, abdominal pain, rash, urticaria, dizziness, hyperactivity, insomnia, confusion etc.
Toxicity
Single 5000 mg/kg oral doses of cefprozil caused no mortality or signs of toxicity in adult, weaning or neonatal rats, or adult mice. A single oral dose of 3000 mg/kg caused diarrhea and loss of appetite in cynomolgus monkeys, but no mortality.
Precaution
History of hypersensitivity to penicillins and GI disease esp colitis. Renal impairment. Pregnancy and lactation.
Interaction
May enhance the nephrotoxic effect of aminoglycosides. May enhance the anticoagulant effect of vit K antagonists. May diminish the therapeutic effect of BCG, typhoid vaccine and Na picosulfate. May increase serum concentrations w/ probenecid.
Food Interaction
- Take with or without food. The absorption is unaffected by food.
Auroprozil Drug Interaction
Unknown: fluticasone / salmeterol, fluticasone / salmeterol, diphenhydramine, diphenhydramine, polyethylene glycol 3350, polyethylene glycol 3350, mometasone nasal, mometasone nasal, acetaminophen, acetaminophen, cyanocobalamin, cyanocobalamin, ascorbic acid, ascorbic acid, cholecalciferol, cholecalciferol, alprazolam, alprazolam, cetirizine, cetirizine
Auroprozil Disease Interaction
Major: colitisModerate: renal dysfunction, PKU, dialysis, liver disease, seizure disorders
Volume of Distribution
- 0.23 L/kg
Elimination Route
Oral bioavailability is approximately 95%.
Half Life
1.3 hours
Clearance
- 3 mL/min/kg [fasting subjects]
Pregnancy & Breastfeeding use
Pregnancy category B. There are no adequate and well-controlled studies in pregnant women. This drug should be used during pregnancy only if clearly needed. Small amounts of cefprozil (<0.3% of dose) have been detected in human milk following administration of a single 1 gram dose to lactating women. Caution should be exercised when cefprozil is administered to a nursing woman, since the effect of cefprozil on nursing infants is unknown.
Contraindication
Hypersensitivity to cephalosporin antibiotics.
Storage Condition
Store between 20-25°C. Reconstituted powder for suspension: Store between 2-8°C.
Innovators Monograph
You find simplified version here Auroprozil
