Autologous cultured chondrocytes
Autologous cultured chondrocytes Uses, Dosage, Side Effects, Food Interaction and all others data.
Autologous cultured chrondrocytes are used as autologous cell therapy to repair articular cartilage injuries in the knee (femoral condyle) due to acute or repetitive trauma. It serves as an alternative repair treatment for patients with inadequate response to pre-existing surgical methods. The surgical implantation shows a tolerable safety profile and efficacy up to 4 years, but it is not indicated for patients with osteoarthritis. It has been used since 1995 as Carticel and gained biologic license in 1997. The surgical implantation was first performed in Sweden.
Autologous cultured chrondrocytes reduce pain and considerably improve function in patients with defected cartilage at femoral joints by producing hyaline-like cartilage repair tissue.
| Trade Name | Autologous cultured chondrocytes |
| Generic | Autologous cultured chondrocytes |
| Type | |
| Groups | Approved, Investigational |
| Therapeutic Class | |
| Manufacturer | |
| Available Country | |
| Last Updated: | September 19, 2023 at 7:00 am |
Uses
Autologous cultured chondrocytes is a cell therapy used to treat damage to cartilage in the knees.
Cellular repair strategy for patients with symptomatic cartilage defects of the femoral condyle (medial, lateral or trochlea) caused by trauma or patients who were previously unresponsive to available surgical procedures.
Autologous cultured chondrocytes is also used to associated treatment for these conditions: For the repair of symptomatic cartilage defects of the femoral condyle (medial, lateral or trochlea), caused by acute or repetitive trauma therapy
How Autologous cultured chondrocytes works
Chrondrocytes are collected from the patient's femoral articular cartilage and isolated cells are expanded through cell culture in vitro. Multiplied chrondrocytes are implanted into articular cartilage defects beneath an autologous periosteal flap. Cells produce hyaline-like cartilage that mainly consists of type II collagen. Type II collagen maintain the macromolecular framework in the extracellular matrix that gives integrity to surrounding hyaline cartilage. The therapy repairs damaged cartilage and restores functional and mechanical ability to withstand compressional, tensile, and shear forces.
Toxicity
Unwanted effects from therapy include arthrofibrosis/joint adhesions, graft overgrowth, chondromalacia or chondrosis, cartilage injury, graft complication, meniscal lesion and graft delamination in less than 5% of total patients who underwent treatment.
Food Interaction
No interactions found.Innovators Monograph
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