Autologous Cultured Fibroblasts

Autologous Cultured Fibroblasts Uses, Dosage, Side Effects, Food Interaction and all others data.

Autologous Cultured Fibroblasts is an autologous cellular product composed of fibroblasts indicated for improvement of the appearance of moderate to severe nasolabial fold wrinkles in adults. Dermal fibroblasts are collected from the post-auricular biopsy tissue and aseptically expanded using standard tissue-culture procedures until sufficient cells for three doses are obtained . Expanded cells are then suspended in a cell medium. As a replacement for lost dermal constituents in the aging or skin deformation process, treatment with autologous fibroblasts has shown to improve wrinkle and acne scar appearance than with placebo treatment . Intradermal administration of autologous dermal fibroblasts into irradiated skin following surgical procedures was associated with an improved healing process of subsequent surgical wounds . Autologous Cultured Fibroblasts is marketed in the US as Laviv for intradermal injection.

In clinical studies involving patients with moderate to severe bilateral nasolabial fold wrinkles, there was a substantial improvement in the wrinkle appearance . In a randomized multicenter, double-blind, placebo-controlled trial in subjects with bilateral moderate to severe acne scarring, treatment of autologous fibroblast treatment was associated with a significant improvement in the appearance of acne scars without permanent adverse reactions .

Autologous Cultured Fibroblasts
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Trade Name	Autologous Cultured Fibroblasts
Generic	Azficel-T
Azficel-T Other Names	Autologous cultured fibroblasts, Azficel-T
Type
Groups	Approved, Investigational
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Available Country
Last Updated:	September 19, 2023 at 7:00 am

Uses

Autologous Cultured Fibroblasts is a medication composed of fibroblasts used to treat moderate to severe nasolabial wrinkles.

Indicated for improvement of the appearance of moderate to severe nasolabial fold wrinkles in adults .

Autologous Cultured Fibroblasts is also used to associated treatment for these conditions: Nasolabial Fold Wrinkles

How Autologous Cultured Fibroblasts works

The mechanism of action of azficel-T, or autologous human fibroblasts, is not fully elucidated. Autologous fibroblasts correct dermal defects such as acne or other dermal conditions associated with aging, such as reduced elasticity. The importance of collagen matrix production by fibroblasts in maintaining skin integrity and reducing the appearance of scars has been highlighted. The appearance of acne scars is also associated with the loss of collagen at the site of inflammation following resolution of localized intense inflammation and wound healing associated with inflammatory acne . Fragmentation of the dermal collagen matrix occurs in the natural aging process; due to UV-induced photodamage and the actions of collagen-degrading enzymes (matrix metalloproteinases, MMPs) overtime, the structural integrity of the dermis and function of fibroblasts may be impaired . While fibroblasts are responsible in the synthesis, organization, regulation and the maintenance of collagen network, the function of fibroblasts are strongly dependent on the physical properties of collagen fibres, and vice versa . The aging process is associated with a reduced rate of collagen turnover and formation of modified crosslinks that normally give structural support for collagen fibres. These crosslinks prevent the removal of degraded collagen, leading to accumulation of collagen fragments within the extracellular matrix, and compromised structural and mechanical integrity of the dermis . Integrins that are expressed by the fibroblasts allow the cell to bind to collagen matrix and allow mechanical tension within fibroblasts and the collagenous matrix. In the presence of fragmented collagen, the fibroblasts lose attachment to the collagen matrix and collapse within the dermis and subsequently leads to reduced collagen production and increased production of MMPs . Autologous human fibroblasts have the ability to increase the formation of human collagen in vivo and promote remodelling of pre-existing extracellular matrix in the scarred tissue . They may also decrease the degradation of collagen .