Avant Oral Rinse

Avant Oral Rinse Uses, Dosage, Side Effects, Food Interaction and all others data.

Sodium fluoride is a cariostatic agent that is used to prevent dental caries. It can also be used as a source of fluoride in total parenteral nutrition.

Sodium fluoride protects the teeth from acid demineralization while preventing tooth decay by bacteria while strengthening tooth enamel. It is important to note that excess fluoride exposure during tooth mineralization, especially in children 1-3 years old, may cause fluorosis. It is a condition manifested by white lines, pitting, or discoloration of teeth resulting from changes in tooth enamel. The risk of fluorosis can be decreased by the use of a rice-size amount of fluoridated toothpaste in children younger than 3 years old. It is recommended that no more than a pea-sized quantity of fluoridated toothpaste should be used for children from 3 to 6 years old. The American Dentistry Association (ADA) recommends that children should be closely supervised during toothpaste use to prevent excess fluoride ingestion.

Trade Name Avant Oral Rinse
Generic Sodium Fluoride
Sodium Fluoride Other Names Sodium fluoride
Type Dental liquid
Formula FNa
Weight Average: 41.9882
Monoisotopic: 41.98817288
Protein binding

Fluoride ions are bound to plasma proteins. The percentage of protein binding is not readily available in the evaluated literature.

Groups Approved
Therapeutic Class Anticavity Mouthwash
Manufacturer
Available Country United States
Last Updated: September 19, 2023 at 7:00 am
Avant Oral Rinse
Avant Oral Rinse

Uses

Sodium fluoride is an antiseptic & anticavity mouthwash which-

  • Restores enamel to strengthen teeth
  • Protects teeth from cavity
  • Helps to prevent tooth decay
  • Controls tartar that can discolor teeth
  • whitens teeth safety

Avant Oral Rinse is also used to associated treatment for these conditions: Caries; Enamel, Cavity, Dental Cavity, Dental Decay, Dental Health, Partial Denture Wearers Wear of the Natural Enamel, Tooth Sensitivity, Trace Element Deficiency, Wear of the Natural Enamel caused by teeth grinding, Parenteral Nutrition

How Avant Oral Rinse works

The prevention of dental caries by topical fluoride is achieved by various mechanisms. Sodium fluoride kills bacteria that cause caries, such a Streptococcus mutans and lactobacilli by interfering with their metabolic activities that result in the formation of lactic acid. Fluoride ions cause the inhibition of glycolytic and other enzymes involved in bacterial metabolism. It changes the permeability of cell membranes, lowering the pH in the cytoplasm of the cell, leading to a decrease in acidity, which is normally implicated in tooth decay.

When administered at low topical doses, fluoride in both saliva and plaque and saliva prevent the demineralization of healthy tooth enamel while remineralizing teeth that have previously been demineralized. Sodium fluoride is absorbed by the surface of hydroxyapatite crystals on the teeth, which are necessary for mineralization. This renders the teeth more resistant to demineralization by changing the apatite crystal solubility. Sodium fluoride inhibits the demineralization of teeth in a pH-related manner. When used in high doses, in formulations such as the fluoride varnishes or gels, sodium fluoride forms a layer on the surface of tooth enamel. When the pH of the mouth is reduced due to acid production by bacteria such as S.mutans, fluoride is released, interfering with bacterial metabolism, and then acts to remineralize the teeth.

Dosage

Avant Oral Rinse dosage

Rinse (gargle) with fall strength Sodium fluoride for 30 seconds with 20 ml (with the help of supplied cup) two times daily (morning and evening). Do not swallow. Don’t eat or drink within 30 minutes after rinsing with Sodium fluoride restoring.

Side Effects

Hypersensitivity reactions, rash, nausea, vomiting. Products containing stannous fluoride may cause teeth staining.

Toxicity

The oral LD50 of sodium fluoride is 44 mg/kg in mice and 31 mg/kg in rats. The oral LD50 of sodium fluoride in rabbits is 200 mg/kg.

Overdose information

The ingestion of toothpaste is the major cause of sodium fluoride overdose. This is followed by sodium fluoride supplements and mouth rinses. Most causes of sodium fluoride toxicity have been observed in children under the age of 6 years old. The manifestations of a sodium fluoride overdose may include gastrointestinal disturbance, abdominal pain, alterations in taste, seizures, salivation, bradycardia, tachycardia, headache, tremor, and shallow breathing. Gastrointestinal bleeding may also occur in addition to a sensation of burning in the mouth. Hypotension, bronchospasm, fixed mydriasis, and elevated potassium can also occur which, in turn, may lead to arrhythmias and cardiac arrest.

Management

If a dose greater than 5 mg fluoride per kilogram of body weight (2.3 mg fluoride per pound of body weight) has been taken, it is advisable to induce vomiting. Administer calcium in an oral, soluble form (for example, 5% calcium gluconate, a solution of calcium lactate, or milk). The patient should seek immediate medical attention. If a sodium fluoride ingestion of 15 mg fluoride/kg of body weight or more occurs (i.e. higher than 6.9 mg fluoride per pound), immediately induce vomiting, provide supportive care, and admit the patient to the hospital for observation.

Precaution

Prolonged treatment with large amounts of fluoride may result in dental fluorosis and osseous changes; do not exceed recommended dosage. Renal impairment. Pregnancy.

Interaction

Absorption of fluoride may be reduced by aluminium, calcium and magnesium salts.

Food Interaction

  • Avoid milk and dairy products. Do no take this drug within 1 hour of consuming dairy products.

Volume of Distribution

Fluoride distributes to the saliva, bones, and teeth, and is also found in lesser quantities in the breastmilk and sweat. After the ingestion of sodium fluoridated drinking water, the fluoride ions are found to distribute to the plasma and blood cells. Plasma levels of fluoride concentrations are twice as the concentrations found in blood cells. Adults have been found to retain 36% of ingested fluoride and children have been found to retain about 50% of a dose. Most of the retained fluoride is localized to bone and teeth and 1% accumulates in soft tissues. Fluoride crosses the placenta and the blood-brain barrier. The central nervous system concentrations of sodium fluoride are estimated to reach 20% the plasma concentrations. Studies conducted in communities with high levels of fluoride in water did not show any increase in birth defects. The placenta is able to regulate the accumulation of excess fluoride, possibly protecting the fetus from high levels of fluoride. Despite this, excessively high exposure to fluoride in utero may lead to skeletal fluorosis.

Elimination Route

Sodium fluoride is 90% absorbed from the gastrointestinal tract, with 77% of absorption in the proximal intestine and about 25% in the stomach. The rate of absorption may vary according to gastric pH. Cmax is reached 20-60 minutes after ingestion. Cmax was estimated to be 848 ± 116 ng/mL after a 20mg sodium fluoride solution was ingested, with a Tmax of 0.46 ± 0.17 hours. The bioavailability of sodium fluoride tablets administered in the fasted state during one pharmacokinetic study approached 100%. Another resource reports a sodium fluoride AUC of 1.14 ± 0.12 μg × h/mL after the ingestion of fluoridated water.

Half Life

The terminal plasma elimination half-life following the ingestion of fluoridated drinking water generally ranges from 3 to 10 hours. The half-life of sodium fluoride in the bones is 20 years.

Clearance

Sodium fluoride is rapidly cleared by the kidneys and depends on various factors, including glomerular filtration rate, urine flow, and urine pH. According to one clinical study evaluating the pharmacokinetics of oral sodium fluoride tablets in healthy young adults, the renal clearance was determined to be 77.4 ± 11.2mL/min for acidic urine and 78.4 ± 6.9mL/min for alkaline urine. Another reference estimates the renal clearance of fluoride ions from sodium fluoridated water at 35–45 mL/min.

Elimination Route

Sodium fluoride is rapidly excreted, mainly in the urine. About 90% of fluoride is filtered by the glomerulus and reabsorbed by the renal tubules. About 10% is excreted in the feces.

Contraindication

Not to use 1 mg tablets in children less then 3 yr of age or when drinking water fluoride content is >= 0.3 ppm.

Acute Overdose

In acute poisoning, symptoms include a salty or soapy taste, increased salivation, GI disturbances, abdominal pain, weakness, drowsiness, faintness and shallow breathing; more serious effects include hypocalcaemia, hypomagnesaemia, hyperkalaemia, tremors, convulsions, cardiac arrhythmias, shock, respiratory arrest and cardiac failure. Death may occur within 2-4 hr. Treatment includes gastric lavage with lime water or a weak solution of another calcium salt to precipitate fluoride. Maintain high urine output, slow IV inj of calcium gluconate 10% may be used for hypocalcaemia and tetany. Magnesium sulfate may be given to treat hypomagnesaemia, and aluminium hydroxide may help to reduce fluoride absorption. Haemodialysis may be considered. Chronic fluoride poisoning may cause skeletal fluorosis resulting in bone pain, stiffness, limited movment and in severe cases, crippling deformities. In children, prolonged excessive intake during tooth development before eruption may cause dental fluorosis characterised by mottled enamel.

Storage Condition

Store in tight plastic containers.

Innovators Monograph

You find simplified version here Avant Oral Rinse

FAQ

What is Avant Oral Rinse used for?

Avant Oral Rinse is used in trace amounts in the fluoridation of drinking water, in toothpaste, in metallurgy, and as a flux, and is also used in pesticides and rat poison. 

How safe is Avant Oral Rinse?

Avant Oral Rinse is safe for use in toothpaste and mouthwash, and most municipal water districts even add small amounts of fluoride to tap water.

How safe is Avant Oral Rinse?

Avant Oral Rinse works by protecting your tooth from acids produced by the bacterial plaque, and it is not a substitute for brushing and flossing.

What are the common side effects of Avant Oral Rinse?

Common side effects of Avant Oral Rinse are include:

  • diarrhea. drowsiness. faintness. increased watering of the mouth.
  • nausea or vomiting. shallow breathing. stomach cramps or pain.
  • tremors. unusual excitement. watery eyes. weaknes

Is Avant Oral Rinse safe during pregnancy?

Normal levels of fluoride intake are usually safe for pregnant women in their second and third trimesters.

Is Avant Oral Rinse safe during breastfeeding?

There is no concrete data on Avant Oral Rinse and breast milk. However, because Avant Oral Rinse is a drug and drugs can be traced in breast milk, we caution the use of excessive fluoride while breast feeding.

Can I drink alcohol with Avant Oral Rinse?

Do not consume hot drinks or alcohol for at least 4 hours after treatment.

What does Avant Oral Rinse do for my teeth?

Avant Oral Rinse makes teeth more resistant to decay and bacteria that cause cavities. This medication is used to prevent cavities.

Can I use Avant Oral Rinse gel everyday?

Avant Oral Rinse once daily or as directed by your dentist/doctor. After brushing with toothpaste, apply this medication to your teeth and brush thoroughly.

Does Avant Oral Rinse help tooth infection?

Avant Oral Rinse treatment for all children as soon as their teeth begin to grow to prevent decay, pain, and future dental infections.

Does Avant Oral Rinse affect the heart?

Avant Oral Rinse causes oxidative stress and degeneration of heart muscle.Avant Oral Rinse inhibits Thyroid function with consequential damage to heart function.

Does Avant Oral Rinse cause high blood pressure?

As per research, there is a significant correlation between high blood pressure and water with too much Avant Oral Rinse.

What happens when I stop using Avant Oral Rinse toothpaste?

Teeth may develop with thinner enamel and a reduced ability to remineralize early symptoms of decay.

How does Avant Oral Rinse prevent tooth decay?

Avant Oral Rinse is one of the most powerful minerals to help prevent tooth decay by making the tooth enamel more resistant to those attacking acids. It can also actually reverse very early decay.

Is Avant Oral Rinse good for babies?

Very small doses of Avant Oral Rinse aren't harmful to babies younger than 6 months old.

How does Avant Oral Rinse affect the body?

Excess exposure to Avant Oral Rinse can lead to a bone disease known as skeletal fluorosis. Over many years, this can result in pain and damage to bones and joints. The bones may become hardened and less elastic, increasing the risk of fractures.

How often should I use Avant Oral Rinse?

Avant Oral Rinse treatments may be recommended every three, six or 12 months. Your dentist also may recommend additional preventive measures if you are at a moderate or high risk of developing caries.

Does Avant Oral Rinse cause tartar?

Tartar build-up can also happen through fluoride from food or dental products. There are a few variables that can affect the rapid formation of tartar, which should be removed through regular dental cleanings.

How long does Avant Oral Rinse take to work?

Some professional Avant Oral Rinse treatments require a waiting period of 30 minutes before eating or drinking anything.Avant Oral Rinse varnishes adhere to the teeth for hours, and no waiting period is required.

What happens if I miss a dose?

If you miss a dose of Avant Oral Rinse take the missed dose as soon as you remember it. You can skip the missed dose if it is almost time for the next dose. You should not take an extra dose to make up for the dose you missed. As soon as possible, get back onto the regular schedule. Contact your doctor or dentist if you are concerned.

How long does Avant Oral Rinse stay in the body?

Avant Oral Rinse is gradually removed via the kidneys, reducing to half its original level in between three and ten hours.

*** Taking medicines without doctor's advice can cause long-term problems.
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