AVC

AVC Uses, Dosage, Side Effects, Food Interaction and all others data.

AVC is a molecule containing the sulfonamide functional group attached to an aniline.

AVC is a sulfonamide antibiotic. The sulfonamides are synthetic bacteriostatic antibiotics with a wide spectrum against most gram-positive and many gram-negative organisms. However, many strains of an individual species may be resistant. Sulfonamides inhibit multiplication of bacteria by acting as competitive inhibitors of p-aminobenzoic acid in the folic acid metabolism cycle. Bacterial sensitivity is the same for the various sulfonamides, and resistance to one sulfonamide indicates resistance to all. Most sulfonamides are readily absorbed orally. However, parenteral administration is difficult, since the soluble sulfonamide salts are highly alkaline and irritating to the tissues. The sulfonamides are widely distributed throughout all tissues. High levels are achieved in pleural, peritoneal, synovial, and ocular fluids. Although these drugs are no longer used to treat meningitis, CSF levels are high in meningeal infections. Their antibacterial action is inhibited by pus.

Trade Name AVC
Generic Sulfanilamide
Sulfanilamide Other Names p-aminobenzenesulfamide, p-aminobenzenesulfonamide, para-aminobenzenesulfonamide, Prontosil album, Streptocide, Sulfamine, Sulfanilamida, Sulfanilamide, Sulfanilamidum, Sulphanilamide
Type Vaginal cream
Formula C6H8N2O2S
Weight Average: 172.205
Monoisotopic: 172.0306482
Groups Approved
Therapeutic Class
Manufacturer
Available Country United States
Last Updated: September 19, 2023 at 7:00 am
AVC
AVC

Uses

AVC is a sulfonamide anti-infective used to treat vulvovaginal candidiasis caused by Candida albicans.

For the treatment of vulvovaginitis caused by Candida albicans.

AVC is also used to associated treatment for these conditions: Vulvovaginal Candidiasis

How AVC works

AVC is a competitive inhibitor of bacterial enzyme dihydropteroate synthetase. This enzyme normally uses para-aminobenzoic acid (PABA) for synthesizing the necessary folic acid. The inhibited reaction is normally necessary in these organisms for the synthesis of folic acid. Without it, bacteria cannot replicate.

Toxicity

Oral, mouse LD50 = 3700 mg/kg; Intravenous, mouse LD50 = 621 mg/kg; Oral, rabbit LD50 = 1300 mg/kg. Side effects include itching, burning, skin rash, redness, swelling, or other sign of irritation not present before use of this medicine and long-term use of sulfonamides may cause cancer of the thyroid gland.

Food Interaction

No interactions found.

Elimination Route

Sulfonamides are absorbed through the vaginal mucosa. There are no pharmacokinetic data available describing how much of an intravaginal dose reaches the systemic circulation.

Innovators Monograph

You find simplified version here AVC

http://classyfire.wishartlab.com/tax_nodes/C0000000
http://classyfire.wishartlab.com/tax_nodes/C0002448
http://classyfire.wishartlab.com/tax_nodes/C0002279
http://classyfire.wishartlab.com/tax_nodes/C0000031
http://classyfire.wishartlab.com/tax_nodes/C0001925
http://classyfire.wishartlab.com/tax_nodes/C0004233
http://classyfire.wishartlab.com/tax_nodes/C0000284
http://classyfire.wishartlab.com/tax_nodes/C0001585
http://classyfire.wishartlab.com/tax_nodes/C0003137
http://classyfire.wishartlab.com/tax_nodes/C0002450
http://classyfire.wishartlab.com/tax_nodes/C0004557
http://classyfire.wishartlab.com/tax_nodes/C0003940
http://classyfire.wishartlab.com/tax_nodes/C0004150
https://www.ebi.ac.uk/chebi/searchId.do?chebiId=CHEBI:45373
http://www.hmdb.ca/metabolites/HMDB0014404
http://www.genome.jp/dbget-bin/www_bget?drug:D08543
http://www.genome.jp/dbget-bin/www_bget?cpd:C07458
https://pubchem.ncbi.nlm.nih.gov/summary/summary.cgi?cid=5333
https://pubchem.ncbi.nlm.nih.gov/summary/summary.cgi?sid=46508306
https://www.chemspider.com/Chemical-Structure.5142.html
http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=10857
https://mor.nlm.nih.gov/RxNav/search?searchBy=RXCUI&searchTerm=10184
https://www.ebi.ac.uk/chebi/searchId.do?chebiId=45373
https://www.ebi.ac.uk/chembldb/index.php/compound/inspect/CHEMBL21
https://zinc.docking.org/substances/ZINC000000002101
http://bidd.nus.edu.sg/group/cjttd/ZFTTDDRUG.asp?ID=DNC001391
http://www.pharmgkb.org/drug/PA451545
https://www.ebi.ac.uk/pdbe-srv/pdbechem/chemicalCompound/show/SAN
https://www.drugs.com/cdi/sulfanilamide.html
https://en.wikipedia.org/wiki/Sulfanilamide
*** Taking medicines without doctor's advice can cause long-term problems.
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