Avro Dispersible

Avro Dispersible Uses, Dosage, Side Effects, Food Interaction and all others data.

A 4-aminoquinoquinoline compound with anti-inflammatory properties.

Amodiaquine, a 4-aminoquinoline similar to chloroquine in structure and activity, has been used as both an antimalarial and an anti-inflammatory agent for more than 40 years. Amodiaquine is at least as effective as chloroquine, and is effective against some chloroquine-resistant strains, although resistance to amodiaquine has been reported. The mode of action of amodiaquine has not yet been determined. 4-Aminoquinolines depress cardiac muscle, impair cardiac conductivity, and produce vasodilatation with resultant hypotension. They depress respiration and cause diplopia, dizziness and nausea.

Avro Dispersible
Uses
Dosage
Side Effect
Precautions
Interactions
Uses during Pregnancy
Uses during Breastfeeding
Accute Overdose
Food Interaction
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Interaction With other Medicine
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Trade Name	Avro Dispersible
Generic	Sulphadoxine/pyrimethamine + Amodiaquine
Weight	500mg/25mg, 150mg
Type	Tablet
Therapeutic Class
Manufacturer	Avro Pharma Limited
Available Country	Nigeria
Last Updated:	September 19, 2023 at 7:00 am

Uses

Amodiaquine is an antimalarial drug.

For treatment of acute malarial attacks in non-immune subjects.

How Avro Dispersible works

The mechanism of plasmodicidal action of amodiaquine is not completely certain. Like other quinoline derivatives, it is thought to inhibit heme polymerase activity. This results in accumulation of free heme, which is toxic to the parasites. The drug binds the free heme preventing the parasite from converting it to a form less toxic. This drug-heme complex is toxic and disrupts membrane function.

Toxicity

LD₅₀ (mouse, intraperitoneal) 225 mg/kg, LD₅₀ (mouse, oral) 550 mg/kg. Symptoms of overdose include headache, drowsiness, visual disturbances, vomiting, hypokalaemia, cardiovascular collapse and cardiac and respiratory arrest. Hypotension, if not treated, may progress rapidly to shock. Electrocardiograms (ECG) may reveal atrial standstill, nodal rhythm, prolonged intraventricular conduction time, broadening of the QRS complex, and progressive bradycardia leading to ventricular fibrillation and/or arrest.