Azelnidipine TCK

Azelnidipine TCK Uses, Dosage, Side Effects, Food Interaction and all others data.

Azelnidipine TCK is a dihydropyridine calcium channel blocker. It is marketed by Daiichi-Sankyo pharmaceuticals, Inc. in Japan. It has a gradual onset of action and produces a long-lasting decrease in blood pressure, with only a small increase in heart rate, unlike some other calcium channel blockers . It is currently being studied for post-ischemic stroke management .

Azelnidipine TCK is a vasodilator that induces a gradual decrease in blood pressure in hypertensive patients. Unlike other members of its drug class, azelnidipine does not induce reflex tachycardia due to vasodilation. This is likely due to the fact that it elicits a gradual fall in blood pressure

It also exhibits a prolonged hypotensive effect and has been shown to have a strong anti-arteriosclerotic action in vessels due to its high affinity for vascular tissue and antioxidative activity .

Trade Name Azelnidipine TCK
Generic Azelnidipine
Azelnidipine Other Names Azelnidipine
Type
Formula C33H34N4O6
Weight Average: 582.657
Monoisotopic: 582.247834831
Protein binding

Azelnidipine is widely bound to human plasma proteins (90%–91%) [L3183].

Groups Investigational
Therapeutic Class
Manufacturer
Available Country
Last Updated: September 19, 2023 at 7:00 am
Azelnidipine TCK
Azelnidipine TCK

Uses

For the treatment of hypertension.

How Azelnidipine TCK works

Azelnidipine TCK inhibits trans-membrane Ca2+ influx through the voltage-dependent channels of smooth muscles in vascular walls. Ca2+ channels are classified into various categories, including L-type, T-type, N-type, P/Q-type, and R-type Ca2+ channels. The L-type Ca2+ channels . Normally, calcium induces smooth muscle contraction, contributing to hypertension. When calcium channels are blocked, the vascular smooth muscle does not contract, resulting in relaxation of vascular smooth muscle walls and decreased blood pressure.

Toxicity

As with any calcium channel blocker toxicity, bradycardia and hypotension may result from overdose. The treatment of patients with bradycardia and hypotension begins with supportive therapy and atropine, however, patients with severe toxicity do not have an adequate response and must be managed more aggressively.

Calcium plays an imperative role in myocardial contractility, automaticity and vascular tone. Administration of exogenous calcium is of benefit in cases of toxicity .

Volume of Distribution

In a Chinese study examining the pharmacokinetics of the drug, the volume of distribution was found to be 1749 +/- 964 .

Elimination Route

Oral ingestion of azelnidipine demonstrates rapid and dose-dependent absorption .

Half Life

16 –28 hours .

Elimination Route

In one study, following a single 4mg oral dose of 14C-labeled azelnidipine in humans, about 26% of the drug was thought to br excreted in the urine and 63% in the feces during the 1 week period post administration .

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*** Taking medicines without doctor's advice can cause long-term problems.
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