Azlocillinum
Azlocillinum Uses, Dosage, Side Effects, Food Interaction and all others data.
Azlocillinum is a semisynthetic ampicillin-derived acylureido penicillin.
Similar to mezlocillin and piperacillin, azlocillin is an acylampicillin that exhibits an extended-spectrum of activity and in vitro potency that is greater than that of the carboxy penicillins. Azlocillinum is shown to be effective against a broad spectrum of bacteria, including Pseudomonas aeruginosa and enterococci.
Trade Name | Azlocillinum |
Generic | Azlocillin |
Azlocillin Other Names | Azlocilina, Azlocillin, Azlocilline, Azlocillinum |
Type | |
Formula | C20H23N5O6S |
Weight | Average: 461.492 Monoisotopic: 461.136904183 |
Protein binding | 20 to 46% bound to plasma proteins |
Groups | Approved |
Therapeutic Class | |
Manufacturer | |
Available Country | |
Last Updated: | September 19, 2023 at 7:00 am |
Uses
For the treatment of infections caused by Pseudomonas aeruginosa, Escherichia coli, and Haemophilus influenzae.
How Azlocillinum works
By binding to specific penicillin-binding proteins (PBPs) located inside the bacterial cell wall, azlocillin inhibits the third and last stage of bacterial cell wall synthesis. Cell lysis is then mediated by bacterial cell wall autolytic enzymes such as autolysins; it is possible that azlocillin interferes with an autolysin inhibitor.
Elimination Route
Not significantly absorbed from the gastrointestinal tract.
Half Life
Mean elimination half-life is 1.3 to 1.5 hours. Longer in neonates, and 2 to 6 hours in patients with renal impairment.
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