Azopt eye drops,
Azopt eye drops, Uses, Dosage, Side Effects, Food Interaction and all others data.
Azopt eye drops, is a carbonic anhydrase II (CA-II) inhibitor that inhibits aqueous humor production to reduce elevated intraocular pressure.
Used in the treatment of glaucoma, brinzolamide inhibits aqueous humor formation and reduces elevated intraocular pressure. Elevated intraocular pressure is a major risk factor in the pathogenesis of optic nerve damage and glaucomatous visual field loss. Azopt eye drops, can decrease intraocular pressure by approximately 16-19% in patients with elevated intraocular pressure.
Trade Name | Azopt eye drops, |
Generic | Brinzolamide |
Brinzolamide Other Names | Brinzolamida, Brinzolamide |
Type | Suspension |
Formula | C12H21N3O5S3 |
Weight | Average: 383.507 Monoisotopic: 383.064332867 |
Protein binding | Approximately 60%. |
Groups | Approved |
Therapeutic Class | Drugs for miotics and glaucoma |
Manufacturer | Novartis Pharmaceuticals UK Ltd |
Available Country | United Kingdom |
Last Updated: | September 19, 2023 at 7:00 am |
Uses
used for the treatment of elevated intraocular pressure in patients with ocular hypertension or open-angle glaucoma.
Azopt eye drops, is also used to associated treatment for these conditions: Increased Intra Ocular Pressure (IOP), Ocular Hypertension
How Azopt eye drops, works
Azopt eye drops, is a highly specific inhibitor of CA-II, which is the main CA isoenzyme involved in the secretion of aqueous humor. Inhibition of CA in the ciliary process of the eye slows the formation of bicarbonate, and reduces sodium and fluid transport. This results in a reduction in the rate of aqueous humor secretion and the intraocular pressure. Azopt eye drops, is absorbed systemically following topical ocular administration. Since it has a high affinity for CA-II, brinzolamide binds extensively to red blood cells, where CA-II is primarily found. As sufficient CA-II activity remains, adverse effects resulting from the systemic inhibition of CA by brinzolamide are not observed. The metabolite N-desethyl brinzolamide is also formed. This metabolite binds to CA and accumulates in red blood cells as well. In the presence of brinzolamide, the metabolite binds mainly to carbonic anhydrase I (CA-I).
Dosage
Azopt eye drops, dosage
Instill 1 drop in the affected eye(s) 2-3 times daily. Zolamid may be used concomitantly with other topical ophthalmic drug to lower intraocular pressure. If more than one topical ophthalmic drug is being used, the drugs should be administered at least ten minutes apart.
Side Effects
Reported side effects are blurred vision and bitter, sour or unusual taste. Other side effects are blepharitis, dermatitis, dry eye, foreign body sensation, headache, hyperemia, ocular discharge, ocular discomfort, ocular keratitis, ocular pain, ocular pruritus and rhinitis.
Precaution
The concomitant administration of Azopt eye drops, 1% ophthalmic suspension and oral carbonic anhydrase inhibitor is not recommended due to no additional benefits.If hypersensitivity reaction occurs after instillation patients should be advised to discontinue the use of Azopt eye drops, and consult with physicians.
Interaction
In patients treated with oral carbonic anhydrase inhibitors, rare instances to drug interactions have occurred with high-dose salicylate therapy. Therefore, the potential for such drug interactions should be considered in patients receiving Azopt eye drops,.
Food Interaction
No interactions found.Elimination Route
Absorbed into systemic circulation following topical ocular application
Half Life
111 days
Pregnancy & Breastfeeding use
Pregnancy Category C.No adequate and well-controlled studies are established in pregnant women. This drug should be used during pregnancy only if the potential benefit justifies the potential risk to the fetus.
It is not known whether Azopt eye drops, is secreted in human milk or not. Caution should be exercised when Azopt eye drops, is administered to a nursing mother.Pediatric Use:Safety and effectiveness are not established in Pediatric patients.
Contraindication
It is contraindicated in patients who are hypersensitive to any component of this product.
Acute Overdose
Although no human data are available, electrolyte imbalance, development of an acidosis state, and possible nervous system effects may occur following oral administration of an overdose. Serum electrolyte levels (particularly potassium) and blood pH levels should be monitored.
Interaction with other Medicine
In patients treated with oral carbonic anhydrase inhibitors, rare instances to drug interactions have occurred with high-dose salicylate therapy.
Storage Condition
- Store in a cool, dry place and protected from light.- Keep out of the reach of children.- Discard the container 4 weeks after opening.- Shake well before using.
Innovators Monograph
You find simplified version here Azopt eye drops,
Azopt eye drops, contains Brinzolamide see full prescribing information from innovator Azopt eye drops, Monograph, Azopt eye drops, MSDS, Azopt eye drops, FDA label