Azosemida

Azosemida Uses, Dosage, Side Effects, Food Interaction and all others data.

Azosemida is a loop diuretic used to treat hypertension, edema, and ascites.

Diuretic affects upon oral administration match those of furosemide. However, upon intravenous administration azosemide displays 5.5 to 8 times greater effect.

Trade Name Azosemida
Generic Azosemide
Azosemide Other Names azosemida, azosémide, Azosemide, azosemidum
Type
Formula C12H11ClN6O2S2
Weight Average: 370.838
Monoisotopic: 370.007342713
Protein binding

> 95% 4% protein binding to 4% human serum albumin at azosemide concentrations of 10-100ug/ml, using equilibrium dialysis.

Groups Investigational
Therapeutic Class
Manufacturer
Available Country
Last Updated: September 19, 2023 at 7:00 am
Azosemida
Azosemida

How Azosemida works

Exact mechanism of action is unclear. However, it acts primarily on the loop of Henle, in both the medullary and cortical segments of the thick ascending limb.

Volume of Distribution

Poor affinity for human tissue. Small apparent post-pseudodistribution Vd of 0.262 l/kg.

Elimination Route

Peak plasma concentrations are achieved in 3-4 hours when azosemide is administered to healthy humans in a fasting state. There is an absorption lag time of approximately 1 hour. Oral bioavailability estimated to be 20.4%

Half Life

Terminal half life 2-3 hours.

Elimination Route

Total body clearance 112ml/min. Renal clearance 41.6ml/min. Actively secreted in the renal proximal tubule of humans. This may or may not involve a nonspecific organic acid secretory pathway. There is thus a potential for disease states and other organic acids such as NSAIDs which affect the organic acid transport pathway to affect the efficacy of azosemide.

Innovators Monograph

You find simplified version here Azosemida

*** Taking medicines without doctor's advice can cause long-term problems.
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