Bactifuse

Bactifuse Uses, Dosage, Side Effects, Food Interaction and all others data.

Fusidic acid is an antimicrobial agent that inhibits bacterial protein synthesis. Fusidic acid interferes with amino acid transfer from aminoacyl-tRNA to protein on the ribosomes. Fusidic acid is active against a wide range of gram-positive organisms. The sustained release formulation ensures prolonged contact with the conjunctival sac. Fusidic acid penetrates well into the aqueous humor.

Fusidic acid is a bacteriostatic antibiotic and helps prevent bacterial growth while the immune system clears the infection.

Trade Name Bactifuse
Generic Fusidic Acid
Fusidic Acid Other Names Acide fusidique, Acido fusidico, Acidum fusidicum, Fucidate, Fucidin acid, Fusidate, Fusidic acid, Fusidine, Ramycin
Type Cream
Formula C31H48O6
Weight Average: 516.7092
Monoisotopic: 516.345089268
Protein binding

97 to 99%

Groups Approved, Investigational
Therapeutic Class Miscellaneous Antibiotics
Manufacturer Macmillon Pharmaceuticals
Available Country India
Last Updated: September 19, 2023 at 7:00 am
Bactifuse
Bactifuse

Uses

Bactifuse is used for the topical treatment of superficial bacterial infections of the eye and its adnexa. These may include - bacterial conjunctivitis, blepharoconjunctivitis, blepharitis, sty and keratitis. It may also be used for the management of corneal and conjunctival abrasions and foreign body injuries.

Bactifuse is also used to associated treatment for these conditions: Bacterial Conjunctivitis, Eye and eyelid infections, Fungal skin infection, Skin Infections caused by Corynebacterium minutissimum infection, Skin Infections caused by Staphylococcus Aureus, Skin Infections caused by Streptococcus Infection, Skin Infections, Bacterial, Stye, Cutaneous dermatophyte infection, Eczematous rash, Mild Atopic dermatitis, Mild Dermatitis caused by Staphylococcus aureusis, Moderate Atopic dermatitis, Moderate Dermatitis caused by Staphylococcus aureusis, Ocular bacterial infections, Susceptible Bacterial Infections

How Bactifuse works

Fusidic acid works by interfering with bacterial protein synthesis, specifically by preventing the translocation of the elongation factor G (EF-G) from the ribosome. It also can inhibit chloramphenicol acetyltransferase enzymes.

Dosage

Bactifuse dosage

Adults and children (≥ 2 years): Instill one drop in the affected eye(s) twice daily for 7 days. Treatment should be continued for at least 48 hours after the eye returns to normal.

Side Effects

Fusidic acid is generally associated with very few adverse effects. The most frequently reported treatment-related side-effect is slight stinging or irritation.

Precaution

  • For ophthalmic use only
  • To avoid possible contamination of the drops, do not touch the tube nozzle or to any surface
  • Do not wear contact lenses during the treatment
  • If more than one topical eye drug is being used, the drugs should be administered at least five (5) minutes interval between applications

Interaction

Synergistic action with antistaphylococcal penicillin. Antagonism with ciprofloxacin.

Food Interaction

  • Take with food. Food reduces irritation.

Elimination Route

Sodium fusidic acid tablets have a 91% oral bioavailability. Absorption of the film-coated tablets is complete when compared to a solution, however oral absorption is variable. Oral fusidic acid hemihydrate (suspension) achieved a 22.5% bioavailability in pediatric patients following a 20 milligram/kilogram dose.

Half Life

Approximately 5 to 6 hours in adults.

Pregnancy & Breastfeeding use

Use in pregnancy: There are no adequate and well-controlled studies in pregnant women. Fusidic acid should be used during pregnancy unless the potential benefit justifies the potential risk to the fetus.

Use in lactation: It is not clear if enough medication from the eye drop would pass into breast milk. Caution should be exercised while giving this eye drops to a nursing mother

Contraindication

Fusidic acid viscous eye drops is contraindicated in patients who are hypersensitive to any component of Bactifuse (Eye Drops).

Special Warning

Use in children: Safety & effectiveness in children below the age of 2 years have not been established.

Storage Condition

Store between 2-25°C. Discard 1 mth after opening.

Innovators Monograph

You find simplified version here Bactifuse

FAQ

What is Bactifuse used for?

Bactifuse is an antibiotic that is often used topically in creams and eyedrops but may also be given systemically as tablets or injections. The global problem of advancing antimicrobial resistance has led to a renewed interest in its use recently. Bactifuse cream should be used on the skin. The cream is used for the local treatment of skin infections caused by bacteria that are sensitive to Bactifuse such as impetigo (a weeping, crusty and swollen patch of skin), folliculitis, sycosis barbae, paronychia, erythrasma.

How safe is Bactifuse?

There is inadequate evidence of safety in human pregnancy. Animal studies and many years of clinical experience suggest that Bactifuse is devoid of teratogenic effects (birth defects), but Bactifuse can cross the placental barrier.

How does Bactifuse work?

Bactifuse works by stopping the growth of the germs causing the infection. 

What are the common side effects of Bactifuse?

Common side effects of Bactifuse are include:

  • Skin rashes.
  • Skin itching.
  • Pain, stinging, burning sensation or redness of skin on application.
  • Contact dermatitis.

Is Bactifuse safe during pregnancy?

It's safe to use Bactifuse cream, ointment or eye drops while you're pregnant. Very little of the medicine gets to your baby, and the small amount that does will not harm them.

Is Bactifuse safe during breastfeeding?

Bactifuse cream can be used during breastfeeding but it is recommended to avoid applying Bactifuse cream on the breast.

Is Bactifuse cream safe for babies?

Using Bactifuse cream topically and breast-feeding is unlikely to harm your baby.

Can I use Bactifuse daily?

Apply a small amount to the affected area 2 to 3 times daily for 7 to 14 days. If your doctor has directed you to cover the lesion with a gauze dressing, you may be directed to apply the medication only 1 or 2 times daily.

How long does Bactifuse stay in my system?

The usual treatment time is up to 2 weeks. You should notice your skin improve after just a few days of using the cream. If there is no improvement after 7 days you should stop using the cream and go back to your doctor.

Is Bactifuse good for acne?

Topical Bactifuse is occasionally used as a treatment for acne vulgaris. As a treatment for acne, Bactifuse is often partially effective at improving acne symptoms.

How often can I use Bactifuse ?

It's usual to put on Bactifuse cream or ointment 3 or 4 times a day.

What happens if I miss a dose of Bactifuse?

If you forget to apply this Bactifuse, apply it as soon as you remember. If it is almost time for your next application, skip the missed dose and continue with your regular schedule. Do not apply a double dose to make up for a missed one.

Who should not take Bactifuse?

Bactifuse topical products should not be used If you have allergic to Bactifuse and its salts or to any of the ingredients of this medication.

When can I stop using Bactifuse ?

Treatment should be stopped after 7 days if your skin has not improved after using Bactifuse cream.

What happen if I take too much Bactifuse?

If you apply too much Bactifuse cream, it is unlikely to cause any harm. However, if you notice any effect or are worried, contact your doctor or pharmacist.

Is Bactifuse a strong antibiotic?

Bactifuse is a steroidal antibiotic and the only marketed member of the fusidane class.

Is Bactifuse an antifungal?

Bactifuse showed that compound 7 had strongest antifungal activity.

Is Bactifuse good for pimples?

Topical Bactifuse is occasionally used as a treatment for acne vulgaris. As a treatment for acne, Bactifuse is often partially effective at improving pimples.

Can Bactifuse be used for cold sores?

No, Bactifuse is inapplicable on cold sores.

Is Bactifuse cream good for cuts?

Bactifuse is made to be put directly on skin and wounds.

*** Taking medicines without doctor's advice can cause long-term problems.
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