Banacep

Banacep Uses, Dosage, Side Effects, Food Interaction and all others data.

Banacep, brand name Lotensin, is a medication used to treat high blood pressure (hypertension), congestive heart failure, and chronic renal failure. Upon cleavage of its ester group by the liver, benazepril is converted into its active form benazeprilat, a non-sulfhydryl angiotensin-converting enzyme (ACE) inhibitor.

Banacep, an angiotensin-converting enzyme (ACE) inhibitor, is a prodrug which, when hydrolyzed by esterases to its active Banacepat, is used to treat hypertension and heart failure, to reduce proteinuria and renal disease in patients with nephropathies, and to prevent stroke, myocardial infarction, and cardiac death in high-risk patients. Banacep and Banacepat inhibit angiotensin-converting enzyme (ACE) in human subjects and animals. ACE is a peptidyl dipeptidase that catalyzes the conversion of angiotensin I to the vasoconstrictor substance, angiotensin II. Angiotensin II also stimulates aldosterone secretion by the adrenal cortex.

Trade Name Banacep
Availability Prescription only
Generic Benazepril
Benazepril Other Names Bénazépril, Benazepril, Benazeprilum
Related Drugs amlodipine, lisinopril, metoprolol, losartan, furosemide, carvedilol, hydrochlorothiazide, spironolactone, valsartan, ramipril
Type
Formula C24H28N2O5
Weight Average: 424.4895
Monoisotopic: 424.199822016
Protein binding

Benazepril is 96.7% protein bound while benazeprilat is 95.3% protein bound.

Groups Approved, Investigational
Therapeutic Class
Manufacturer
Available Country Belgium, Italy, Netherlands, United Kingdom
Last Updated: September 19, 2023 at 7:00 am
Banacep
Banacep

Uses

Banacep is an ACE inhibitor prodrug used to treat hypertension.

Banacep is indicated for the treatment of hypertension. It may be used alone or in combination with thiazide diuretics.

Banacep is also used to associated treatment for these conditions: Diabetic Nephropathy, Heart Failure, High Blood Pressure (Hypertension), Uncontrolled Hypertension, Nondiabetic nephropathy

How Banacep works

Banacepat, the active metabolite of Banacep, competes with angiotensin I for binding at the angiotensin-converting enzyme, blocking the conversion of angiotensin I to angiotensin II. Inhibition of ACE results in decreased plasma angiotensin II. As angiotensin II is a vasoconstrictor and a negative-feedback mediator for renin activity, lower concentrations result in a decrease in blood pressure and stimulation of baroreceptor reflex mechanisms, which leads to decreased vasopressor activity and to decreased aldosterone secretion.

Toxicity

The most common adverse effects include headache, dizziness, fatigue, somnolence, postural dizziness, nausea, and cough.

The most likely symptom of overdosage is severe hypotension.

Food Interaction

  • Avoid potassium-containing products. Potassium products increase the risk of hyperkalemia.
  • Take with or without food. Food slows the rate of absorption but not the extent.

[Moderate] GENERALLY AVOID: Moderate-to-high dietary intake of potassium can cause hyperkalemia in some patients who are using angiotensin converting enzyme (ACE) inhibitors.

In some cases, affected patients were using a potassium-rich salt substitute.

ACE inhibitors can promote hyperkalemia through inhibition of the renin-aldosterone-angiotensin (RAA) system.



MANAGEMENT: It is recommended that patients who are taking ACE inhibitors be advised to avoid moderately high or high potassium dietary intake.

Particular attention should be paid to the potassium content of salt substitutes.

Banacep Alcohol interaction

[Moderate]

Many psychotherapeutic and CNS-active agents (e.g., anxiolytics, sedatives, hypnotics, antidepressants, antipsychotics, opioids, alcohol, muscle relaxants) exhibit hypotensive effects, especially during initiation of therapy and dose escalation.

Coadministration with antihypertensives and other hypotensive agents, in particular vasodilators and alpha-blockers, may result in additive effects on blood pressure and orthostasis.

Caution and close monitoring for development of hypotension is advised during coadministration of these agents.

Some authorities recommend avoiding alcohol in patients receiving vasodilating antihypertensive drugs.

Patients should be advised to avoid rising abruptly from a sitting or recumbent position and to notify their physician if they experience dizziness, lightheadedness, syncope, orthostasis, or tachycardia.

Volume of Distribution

The final population pharmacokinetic model in one study estimated the volume of distribution to be 203±69.9L.

Elimination Route

Bioavailability of oral dosing is 3% to 4% in horses. In humans at least 37% of oral benazepril is absorbed and reaches peak plasma concentration in 0.5 hours to 1 hour. Other studies have shown a peak plasma concentration at a median of 1.5 hours.

Half Life

The half life of the prodrug benazepril is 2.7±8.5h. The half life of the active metabolite benazeprilat is 22.3±9.2h The accumulation half life of benazepril is 10 to 11 hours.

Clearance

The final population pharmacokinetic model of one study estimates the clearance to be 129±30.0L.

Elimination Route

Banacep and benazeprilat are cleared predominantly by renal excretion in healthy subjects with normal renal function. Nonrenal (i.e., biliary) excretion accounts for approximately 11%-12% of benazeprilat excretion in healthy subjects.

Innovators Monograph

You find simplified version here Banacep

*** Taking medicines without doctor's advice can cause long-term problems.
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