Bang Yi
Bang Yi Uses, Dosage, Side Effects, Food Interaction and all others data.
Bang Yi is a non-aminoglycoside semi-synthetic antibacterial derived from rifamycin SV. It inhibits bacterial RNA synthesis by binding to the bacterial DNA-dependent RNA polymerase and has antibacterial activity against Escherichia coli (E. coli).
Bang Yi is a structural analog of rifampin and a non-systemic, gastrointestinal site-specific antibiotic. This non-systemic property of the drug is due to the addition of a pyridoimidazole ring, which renders it non-absorbable. Bang Yi acts by inhibiting bacterial ribonucleic acid (RNA) synthesis and contributes to restore intestinal microflora imbalance. Other studies have also shown rifaximin to be an pregnane X receptor (PXR) activator. As PXR is responsible for inhibiting the proinflammatory transcription factor NF-kappa B (NF-κB) and is inhibited in inflammatory bowel disease (IBD), rifaximin was proven to be effective for the treatment of IBS-D.
| Trade Name | Bang Yi |
| Availability | Prescription only |
| Generic | Rifaximin |
| Rifaximin Other Names | Rifaxidin, Rifaximin, Rifaximina, Rifaximine, Rifaximinun |
| Related Drugs | ciprofloxacin, dicyclomine, sulfamethoxazole / trimethoprim, Bactrim, loperamide, lactulose, Bentyl, hyoscyamine, Xifaxan, Imodium |
| Type | |
| Formula | C43H51N3O11 |
| Weight | Average: 785.8785 Monoisotopic: 785.352359489 |
| Groups | Approved, Investigational |
| Therapeutic Class | Miscellaneous Antibiotics |
| Manufacturer | |
| Available Country | China |
| Last Updated: | September 19, 2023 at 7:00 am |
Uses
Acute infectious diarrhoea including travelers diarrhoea, Diarrhoea predominant Irritable Bowel Syndrome (IBS-D), Hepatic Encephalopathy (H.E.)
Bang Yi is also used to associated treatment for these conditions: Bacterial Infections, Clostridium difficile infection recurrence, Hepatic Encephalopathy (HE), Irritable Bowel Syndrome (IBS), Traveler's Diarrhea
How Bang Yi works
Bang Yi acts by inhibiting RNA synthesis in susceptible bacteria by binding to the beta-subunit of bacterial deoxyribonucleic acid (DNA)-dependent ribonucleic acid (RNA) polymerase enzyme. This binding blocks translocation, which stops transcription.
Dosage
Bang Yi dosage
Acute Infectious Diarrhoea including Travelers’ Diarrhoea: 200 mg three times daily for 3 days.
Diarrhoea predominant Irritable Bowel Syndrome (IBS-D): 550 mg three times daily for 14 days.
Hepatic Encephalopathy (H.E.): 550 mg twice daily
Side Effects
Common side effects are nausea, vomiting, abdominal pain, flatulence, headache and dizziness.
Toxicity
LD50 > 2 g/kg (orally, in rats)
Precaution
Pregnancy and lactation. Caution in severe hepatic impairment (Child-Pugh class C). Not effective against diarrhoea caused by pathogen other than E. coli ; or diarrhoea complicated by fever and/or blood in the stool. Prolonged use may result in Clotridum difficile-associated diarrhoea. Severe hepatic impairment (Child-pugh class C).
Interaction
Although In vitro studies demonstrated the potential of Bang Yi to interact with cytochrome P450 (CYP3A4), a clinical drug-drug interaction study demonstrated that Bang Yi did not significantly affect the pharmacokinetics of midazolam. An additional clinical drug-drug interaction study showed no effect of Bang Yi on the presystemic metabolism of an oral contraceptive containing ethinyl estradiol and norgestimate. Therefore, clinical interactions with drugs metabolized by human cytochrome P450 isozymes are not expected.
Food Interaction
- Take with or without food. Fatty meals may increase the systemic AUC of rifaximin, but do not impact Cmax. Bang Yi is an antibacterial used for local action in the gastrointestinal tract; therefore, changes in systemic exposure may not significantly impact efficacy.
Bang Yi Drug Interaction
Unknown: aspirin, lorazepam, amoxicillin / clavulanate, diphenhydramine, duloxetine, metronidazole, furosemide, pregabalin, polyethylene glycol 3350, esomeprazole, acetaminophen, pantoprazole, acetaminophen, cyanocobalamin, ascorbic acid, cholecalciferol, alprazolam, ondansetron, sertraline, cetirizine
Bang Yi Disease Interaction
Elimination Route
Low absorption in both the fasting state and when administered within 30 minutes of a high-fat breakfast.
Half Life
Approximately 6 hours.
Elimination Route
In a mass balance study, after administration of 400 mg 14C-rifaximin orally to healthy volunteers, of the 96.94% total recovery, 96.62% of the administered radioactivity was recovered in feces almost exclusively as the unchanged drug and 0.32% was recovered in urine mostly as metabolites with 0.03% as the unchanged drug.Bang Yi accounted for 18% of radioactivity in plasma. This suggests that the absorbed rifaximin undergoes metabolism with minimal renal excretion of the unchanged drug
Pregnancy & Breastfeeding use
Pregnancy Category C. There are no adequate and well-controlled studies in pregnant women. Bang Yi should be used during pregnancy only if the potential benefit outweighs the potential risk to the fetus.
Use in Lactation: It is not known whether Bang Yi is excreted in human milk. Because many drugs are excreted in human milk and because of the potential for adverse reactions in nursing infants from Bang Yi, a decision should be made whether to discontinue nursing or to discontinue the drug, taking into account the importance of the drug to the mother.
Contraindication
Bang Yi is contraindicated in patients with a hypersensitivity to Bang Yi, or any of the Rifamycin antimicrobial agents, or any of the components of Bang Yi.
Special Warning
Use in Children: The safety and effectiveness of Bang Yi 200 mg in pediatric patients with travelers’ diarrhoea less than 12 years of age have not established.The safety and effectiveness of Bang Yi 550 mg for hepatic encephalopathy have not been established in patients <18 years of age.
Use in geriatric patients: Clinical studies of Bang Yi tablets did not include sufficient numbers of subjects aged 65 and over to determine whether they respond differently than younger subjects.
Use in Renal Insufficient Patients:The pharmacokinetics of Bang Yi in patients with impaired renal function has not been studied.
Use in Hepatic Insufficient Patients:No dosage adjustment with Bang Yi is necessary due to its limited systemic absorption. Nonetheless, caution should be exercised when Bang Yi is administered to patients with severe hepatic impairment.
Acute Overdose
No specific information is available on the treatment of over dosage with Bang Yi. In case of over dosage, discontinue Bang Yi, treat symptomatically and institute supportive measures as required.
Storage Condition
Store at 20-25° C; excursions permitted to 15-30° C.
Innovators Monograph
You find simplified version here Bang Yi
Bang Yi contains Rifaximin see full prescribing information from innovator Bang Yi Monograph, Bang Yi MSDS, Bang Yi FDA label
FAQ
What is Bang Yi used for?
Bang Yi is used to treat traveler's diarrhea that is caused by a bacteria called Escherichia coli. It is also used to prevent hepatic encephalopathy, which is a condition that occurs when your liver does not work normally.Bang Yi is also used to treat irritable bowel syndrome with diarrhea.
How safe is Bang Yi?
Bang Yi is safe and well tolerated for long-term maintenance of remission from overt hepatic encephalopathy.
How does Bang Yi work?
Bang Yi treats traveler's diarrhea and irritable bowel syndrome by stopping the growth of the bacteria that cause diarrhea. Bang Yi treats hepatic encephalopathy by stopping the growth of bacteria that produce toxins and that may worsen liver disease.
What are the common side effects of Bang Yi?
Common side effects of Bang Yi are include:
- Gas (flatulence)
- Headache
- Feeling as if your bowels are not completely emptied
- Feeling you need to urgently empty your bowels
- Abdominal or stomach pain
- Nausea
- Constipation
- Fever
- Vomiting
- Bloating
- Dizziness
- Tired feeling
- Swelling in your hands, feet, or torso
Is Bang Yi safe during pregnancy?
There are no adequate and well controlled studies in pregnant women.Bang Yi tablets should be used during pregnancy only if the potential benefit justifies the potential risk to the fetus.
Is Bang Yi safe during breastfeeding?
Bang Yi is poorly absorbed orally and used only for gastrointestinal infections. It is not likely to reach the breastmilk or bloodstream of the infant or cause any adverse effects in breastfed infants after maternal use.
When Is the best taken of Bang Yi?
Bang Yi usually 2 times a day (every 12 hours).Take this medication at the same time(s) every day.
Can I take Bang Yi on an empty stomach?
Bang Yi should be taken on an empty stomach.
Should Bang Yi be taken with food?
You may take this medicine with or without food.
Is Bang Yi strong antibiotic?
Bang Yi is a gastrointestinal-selective antibiotic with a broad spectrum of antimicrobial activity, an excellent safety profile, minimal drug interactions, and negligible impact on the intestinal microbiome.
How fast does Bang Yi work?
After just two weeks of treatment, relief lasted for up to 6 months.
Who should not take Bang Yi?
You should not take Bang Yi if you are allergic to Bang Yi. Tell your doctor if you have ever had.Tell your doctor if you are pregnant or breastfeeding.Bang Yi should not be given to a child younger than 12 years old.
Is Bang Yi safe for liver?
Bang Yi could theoretically prevent SBP in patients with liver cirrhosis by reducing gut bacteria.
Can Bang Yi help constipation?
The antibiotic Bang Yi is used to treat non-constipated irritable bowel syndrome (IBS).
How long can I take Bang Yi?
You may take Bang Yi with or without food. For travelers' diarrhea, Bang Yi is usually taken for only 3 days.
Is Bang Yi safe for kidneys?
While the effects of Bang Yi have been shown to be protective against acute kidney injury and hepatorenal syndrome in alcohol-induced cirrhosis, its long-term effects on the renal function of other cirrhotic patients are unknown.
What happens if I miss a dose of Bang Yi?
Take Bang Yi as soon as you can, but skip the missed dose if it is almost time for your next dose. Do not take two doses at one time.
What should I avoid while taking Bang Yi?
Antibiotic medicines can cause diarrhea, which may be a sign of a new infection. If you have diarrhea that is watery or bloody, call your doctor before using anti-diarrhea medicine.
How many Bang Yi can Bang Yi take in a day?
Adults and children 12 years of age and older 200 milligrams (mg) three times a day for 3 days. Children younger than 12 years of age.Use and dose must be determined by your doctor.
