Banocide

Banocide Uses, Dosage, Side Effects, Food Interaction and all others data.

Banocide is an anthelmintic drug that does not resemble other antiparasitic compounds. It is a synthetic organic compound which is highly specific for several parasites and does not contain any toxic metallic elements. Banocide continues to be the mainstay for treatment of patients with lymphatic filariasis and loiasis.

The mechanism of action of diethylcarbamazine is thought to involve sensitizing the microfilariae to phagocytosis. One study showed that diethylcarbamazine's activity against Brugia malayi microfilariae is dependent on inducible nitric-oxide synthase and the cyclooxygenase pathway. It confirmed the important role of the arachidonic acid metabolic pathway in diethylcarbamazine's mechanism of action in vivo and showes that in addition to its effects on the 5-lipoxygenase pathway, it targets the cyclooxygenase pathway and COX-1.

Banocide is an anthelmintic drug that does not resemble other antiparasitic compounds. It is a synthetic organic compound which is highly specific for several parasites and does not contain any toxic metallic elements.

Trade Name Banocide
Generic Diethylcarbamazine
Diethylcarbamazine Other Names Diethylcarbamazin, DiƩthylcarbamazine, Diethylcarbamazine, Diethylcarbamazinum, Dietilcarbamazina
Weight 50mg,
Type Tablet
Formula C10H21N3O
Weight Average: 199.2932
Monoisotopic: 199.168462309
Groups Approved, Investigational, Vet approved
Therapeutic Class Other Anti-protozoals
Manufacturer Glaxosmithkline, Glaxosmithkline Pharma, Glaxowellcome
Available Country India, Saudi Arabia,
Last Updated: September 19, 2023 at 7:00 am
Banocide
Banocide

Uses

Banocide is used for Filariasis, Lymphatic filariasis, Pulmonary eosinophilia, Loiasis, Toxocariasis.

Banocide is also used to associated treatment for these conditions: Filarial Infection, Onchocerciasis

How Banocide works

The mechanism of action of diethylcarbamazine is thought to involve sensitizing the microfilariae to phagocytosis. One study showed that diethylcarbamazine's activity against Brugia malayi microfilariae is dependent on inducible nitric-oxide synthase and the cyclooxygenase pathway. It confirmed the important role of the arachidonic acid metabolic pathway in diethylcarbamazine's mechanism of action in vivo and showes that in addition to its effects on the 5-lipoxygenase pathway, it targets the cyclooxygenase pathway and COX-1.

Dosage

Banocide dosage

Inital: 1 mg/kg/day, may increase to 6 mg/kg/day over 3 days, then maintain for 3 wk. Prophylaxis of loiasis 300 mg/wk.

Side Effects

Fever, headache, vomiting, dizziness, drowsiness, nausea, chills.

Potentially Fatal: Severe hypersensitivity reactions may occur especially in the treatment of onchocerciasis where rare Mazzotti reaction characterised by rash, itching, headache, muscle and joint pains, tachycardia, postural hypotension may start within 2 hr of drug administration. Encephalitis and retinal haemorrhage.

Toxicity

Oral LD50 in rat and mouse is 1400 mg/kg and 660 mg/kg, respectively.

Precaution

Patients with poor health.

Lactation: not known if excreted in breast milk.

Interaction

There are no known drug interactions and none well documented.

Elimination Route

Readily absorbed following oral administration.

Half Life

Approximately 8 hours.

Pregnancy & Breastfeeding use

Pregnancy Category- X. Studies in animals or humans have demonstrated fetal abnormalities and/or there is positive evidence of human fetal risk based on adverse reaction data from investigational or marketing experience, and the risks involved in use of the drug in pregnant women clearly outweigh potential benefits.

Contraindication

Pregnancy, hypersensitivity; lactation; infants, elderly or debilitated patients; impaired renal function; cardiac disease.

Innovators Monograph

You find simplified version here Banocide

Banocide contains Diethylcarbamazine see full prescribing information from innovator Banocide Monograph, Banocide MSDS, Banocide FDA label

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*** Taking medicines without doctor's advice can cause long-term problems.
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