Bardoxolone methyl Uses, Dosage, Side Effects and more
| Attribute | Details |
|---|---|
| Trade Name | Bardoxolone methyl |
| Generic | Bardoxolone methyl |
| Bardoxolone methyl Other Names | Bardoxolone methyl |
| Type | |
| Formula | C32H43NO4 |
| Weight | Average: 505.699 Monoisotopic: 505.319208869 |
| Groups | Investigational |
| Therapeutic Class | |
| Manufacturer | |
| Available Country | |
| Last Updated: | January 7, 2025 at 1:49 am |
Uses
Investigated for use/treatment in lymphoma (unspecified), multiple myeloma, and solid tumors.
How Bardoxolone methyl works
RTA 402 inhibits the activity of nuclear factor kappa-B (NF-kB) activated by tumor necrosis factor (TNF) and other inflammatory agents in a variety of cancer cells. It is a novel targeted cancer therapy with a unique mechanism of action. It exploits fundamental physiological differences between cancerous and noncancerous cells by modulating oxidative stress response pathways. As a result, the drug is toxic to cancer cells but induces protective antioxidant and anti-inflammatory responses in normal cells.
