Bei Le Si

Bei Le Si Uses, Dosage, Side Effects, Food Interaction and all others data.

Bei Le Si is an anti-inflammatory drug used in the treatment of Inflammatory Bowel Disease. It is sold under the name "Colazal" in the US and "Colazide" in the UK.

The chemical name is (E)-5-[[-4-(2-carboxyethyl) aminocarbonyl] phenyl]azo] -2-hydroxybenzoic acid. It is usually administered as the disodium salt.

Bei Le Si works by deliverying mesalazine to the large intestine to act directly on ulcerative colitis. Mesalazine is also known as 5-aminosalicylic acid, or 5-ASA.

Trade Name Bei Le Si
Availability Prescription only
Generic Balsalazide
Balsalazide Other Names Balsalazida, Balsalazide, Balsalazidum
Related Drugs Lialda, Pentasa, Apriso, Azulfidine, Asacol, Canasa, Delzicol, Asacol HD, Dipentum, Rowasa
Type
Formula C17H15N3O6
Weight Average: 357.3175
Monoisotopic: 357.096085227
Protein binding

≥99%

Groups Approved, Investigational
Therapeutic Class
Manufacturer
Available Country China
Last Updated: September 19, 2023 at 7:00 am
Bei Le Si
Bei Le Si

Uses

Bei Le Si is an aminosalicylate used to treat ulcerative colitis.

For the treatment of mildly to moderately active ulcerative colitis.

Bei Le Si is also used to associated treatment for these conditions: Mild Ulcerative Colitis, Moderate Ulcerative colitis

How Bei Le Si works

The mechanism of action of 5-aminosalicylic acid is unknown, but appears exert its anti-inflammatory effects locally (in the GI tract) rather than systemically. Mucosal production of arachidonic acid metabolites, both through the cyclooxygenase pathways (catalyzes the formation of prostaglandin precursors from arachidonic acid), and through the lipoxygenase pathways (catalyzes the formation of leukotrienes and hydroxyeicosatetraenoic acids from arachidonic acid and its metabolites), is increased in patients with chronic inflammatory bowel disease. Therefore, it is possible that 5-aminosalicylic acid diminishes inflammation by blocking production of arachidonic acid metabolites in the colon through both the inhibition of cyclooxygenase and lipoxygenase.

Toxicity

A single oral dose of balsalazide disodium at 5 grams/kg or 4-aminobenzoyl-(beta)-alanine, a metabolite of balsalazide disodium, at 1 gram/kg was non-lethal in mice and rats. No symptoms of acute toxicity were seen at these doses.

Food Interaction

  • Take with or without food.

Bei Le Si Disease Interaction

Moderate: renal dysfunction

Elimination Route

Low and variable, intact balsalazide is poorly absorbed systemically.

Half Life

Half-life could not be determined.

Elimination Route

The products of the azoreduction of this compound, 5-ASA and 4-aminobenzoyl-ß-alanine, and their N-acetylated metabolites have been identified in plasma, urine and feces. Following single-dose administration of 2.25 g COLAZAL (three 750 mg capsules) under fasting conditions in healthy subjects, mean urinary recovery of balsalazide, 5-ASA, and N-Ac-5-ASA was 0.20%, 0.22% and 10.2%, respectively.

Innovators Monograph

You find simplified version here Bei Le Si

*** Taking medicines without doctor's advice can cause long-term problems.
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