Benazepril HCl/Hydrochloorthiazide
Benazepril HCl/Hydrochloorthiazide Uses, Dosage, Side Effects, Food Interaction and all others data.
Benazepril, brand name Lotensin, is a medication used to treat high blood pressure (hypertension), congestive heart failure, and chronic renal failure. Upon cleavage of its ester group by the liver, benazepril is converted into its active form benazeprilat, a non-sulfhydryl angiotensin-converting enzyme (ACE) inhibitor.
Benazepril, an angiotensin-converting enzyme (ACE) inhibitor, is a prodrug which, when hydrolyzed by esterases to its active Benazeprilat, is used to treat hypertension and heart failure, to reduce proteinuria and renal disease in patients with nephropathies, and to prevent stroke, myocardial infarction, and cardiac death in high-risk patients. Benazepril and Benazeprilat inhibit angiotensin-converting enzyme (ACE) in human subjects and animals. ACE is a peptidyl dipeptidase that catalyzes the conversion of angiotensin I to the vasoconstrictor substance, angiotensin II. Angiotensin II also stimulates aldosterone secretion by the adrenal cortex.
| Trade Name | Benazepril HCl/Hydrochloorthiazide |
| Generic | Benazepril + Diuretika |
| Type | |
| Therapeutic Class | |
| Manufacturer | Hexal |
| Available Country | Netherlands |
| Last Updated: | September 19, 2023 at 7:00 am |
Uses
Benazepril is an ACE inhibitor prodrug used to treat hypertension.
Benazepril is indicated for the treatment of hypertension. It may be used alone or in combination with thiazide diuretics.
Benazepril HCl/Hydrochloorthiazide is also used to associated treatment for these conditions: Diabetic Nephropathy, Heart Failure, High Blood Pressure (Hypertension), Uncontrolled Hypertension, Nondiabetic nephropathy
How Benazepril HCl/Hydrochloorthiazide works
Benazeprilat, the active metabolite of Benazepril, competes with angiotensin I for binding at the angiotensin-converting enzyme, blocking the conversion of angiotensin I to angiotensin II. Inhibition of ACE results in decreased plasma angiotensin II. As angiotensin II is a vasoconstrictor and a negative-feedback mediator for renin activity, lower concentrations result in a decrease in blood pressure and stimulation of baroreceptor reflex mechanisms, which leads to decreased vasopressor activity and to decreased aldosterone secretion.
Toxicity
The most common adverse effects include headache, dizziness, fatigue, somnolence, postural dizziness, nausea, and cough.
The most likely symptom of overdosage is severe hypotension.
Volume of Distribution
The final population pharmacokinetic model in one study estimated the volume of distribution to be 203±69.9L.
Elimination Route
Bioavailability of oral dosing is 3% to 4% in horses. In humans at least 37% of oral benazepril is absorbed and reaches peak plasma concentration in 0.5 hours to 1 hour. Other studies have shown a peak plasma concentration at a median of 1.5 hours.
Half Life
The half life of the prodrug benazepril is 2.7±8.5h. The half life of the active metabolite benazeprilat is 22.3±9.2h The accumulation half life of benazepril is 10 to 11 hours.
Clearance
The final population pharmacokinetic model of one study estimates the clearance to be 129±30.0L.
Elimination Route
Benazepril and benazeprilat are cleared predominantly by renal excretion in healthy subjects with normal renal function. Nonrenal (i.e., biliary) excretion accounts for approximately 11%-12% of benazeprilat excretion in healthy subjects.
Innovators Monograph
You find simplified version here Benazepril HCl/Hydrochloorthiazide
