Bencilpenicilina Procaína
Bencilpenicilina Procaína Uses, Dosage, Side Effects, Food Interaction and all others data.
Bencilpenicilina Procaína (INN), also known as procaine G penicillin, is an injectable antiobiotic. It is a poorly soluble salt form of penicillin which is a combination of naturally occuring benzylpenicillin (penicillin G) and the local anaesthetic agent procaine in equimolar amounts. Bencilpenicilina Procaína is administered by deep intramuscular injection. It is slowly absorbed and hydrolyzed to benzylpenicillin. This drug is used where prolonged exposure to benzylpenicillin at a low concentration is required. This combination is aimed at reducing the pain and discomfort associated with a large intramuscular injection of penicillin. It is widely used in veterinary settings. Benzylpenicillin is active against a wide range of organisms and is the drug of first choice for many infections.
It is an antibiotic against penicillin-susceptible microorganisms with bactericidal effect. Like all penicillins, procaine benzylpenicillin interferes with the synthesis of the bacterial cell wall peptidoglycan. It acts through the inhibition of biosynthesis of cell-wall peptidoglycan, rendering the cell wall osmotically unstable. It is part of the penicillin and beta lactam family of antibacterial drugs.
| Trade Name | Bencilpenicilina Procaína |
| Generic | Procaine benzylpenicillin |
| Procaine benzylpenicillin Other Names | Bencilpenicilina procaína, Penicillin G procaine |
| Type | |
| Formula | C29H38N4O6S |
| Weight | Average: 570.71 Monoisotopic: 570.251206134 |
| Protein binding | Approximately 60% of penicillin G is bound to serum protein. |
| Groups | Approved, Vet approved |
| Therapeutic Class | |
| Manufacturer | |
| Available Country | |
| Last Updated: | September 19, 2023 at 7:00 am |
Uses
Bencilpenicilina Procaína is a local anesthetic and antibiotic combination for intramuscular injection to treat a variety of bacterial infections while reducing pain from a deep intramuscular injection.
For the treatment of a number of bacterial infections such as syphilis, anthrax, mouth infections, pneumonia and diphtheria.
Bencilpenicilina Procaína is also used to associated treatment for these conditions: Anthrax, Bacterial Infections, Diphtheria, Endocarditis, Subacute Bacterial, Erysipelas, Erysipelas caused by susceptible streptococci, Erysipeloid, Necrotizing ulcerative gingivostomatitis, Non-venereal endemic syphilis, Otitis Media caused by susceptible pneumococci, Pinta, Pneumonia caused by susceptible pneumococci, Primary Syphilis, Rat-bite fever, Respiratory Tract Infections (RTI), Scarlet Fever, Scarlet Fever caused by susceptible streptococci, Secondary Syphilis, Skin Structures and Soft Tissue Infections caused by susceptible streptococci, Skin and Subcutaneous Tissue Bacterial Infections, Tertiary syphilis, Upper Respiratory Tract Infection caused by susceptible streptococci, Yaws
How Bencilpenicilina Procaína works
Bencilpenicilina Procaína is hydrolyzed into penicillin G once it is released from the injection site. Penicillin G attaches to the penicillin-binding proteins on bacterial cell wall and inhibit the transpeptidation enzyme that crosslinks the peptide chains attached to the backbone of the peptidoglycan. The final bactericidal event involves the inactivation of an inhibitor of autolytic enzymes in the cell wall, leading to lysis of the bacterium .
Toxicity
Bencilpenicilina Procaína is associated with the pain at the injection site, blood clotting problems, and seizures. Treatment targeted against syphilis is often associated with Jarisch-Herxheimer reaction. The main unwanted effects are hypersensitivity reactions caused by the degradation products of penicillin, which combine with host protein and become antigenic. Other common adverse effects include skin rashes, fever and delayed serum sickness. Rare but fatal anaphylactic shock may occur. Oral LD50 values in mouse and rat are > 2000 mg/kg. Overdosage can cause convulsions, paralysis and even death. Emesis and gastric lavage may be of value if begun within a few hours of injection. Excessive blood concentrations can be lowered by haemodialysis .
Food Interaction
No interactions found.Volume of Distribution
The drug is distributed throughout the body tissues in widely varying amounts and spinal fluid to a lesser degree. Highest levels are found in the kidneys with lesser amounts in the liver, skin, and intestines. It displays low solubility thus results in blood serum levels much lower but more prolonged than other parenteral penicillins.
Elimination Route
After intramuscular injection, it dissolves slowly at the site of injection, giving a plateau type of blood level at about 4 hours which falls slowly over a period of the next 15 to 20 hours.
Half Life
Intramuscular injection of benzylpenicillin has a plasma half-life of 30 minutes .
Elimination Route
The drug is rapidly and predominantly cleared via renal elimination, with 90% being through tubular secretion. Approximately 60 -90 % of a dose of parenteral penicillin G is excreted in the urine within 24 to 36 hours.
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