Benflumetol

Benflumetol Uses, Dosage, Side Effects, Food Interaction and all others data.

Benflumetol is an antimalarial agent used to treat acute uncomplicated malaria. It is administered in combination with artemether for improved efficacy. This combination therapy exerts its effects against the erythrocytic stages of Plasmodium spp. and may be used to treat infections caused by P. falciparum and unidentified Plasmodium species, including infections acquired in chloroquine-resistant areas.

Benflumetol is a blood schizonticide active against erythrocytic stages of Plasmodium falciparum. It is thought that administration of lumefantrine with artemether results in cooperate antimalarial clearing effects. Artemether has a rapid onset of action and is rapidly cleared from the body. It is thus thought to provide rapid symptomatic relief by reducing the number of malarial parasites. Benflumetol has a much longer half life and is believed to clear residual parasites.

Trade Name Benflumetol
Generic Lumefantrine
Lumefantrine Other Names Benflumetol, dl-Benflumelol, Lumefantrine
Type
Formula C30H32Cl3NO
Weight Average: 528.94
Monoisotopic: 527.154947772
Protein binding

99.7% bound

Groups Approved
Therapeutic Class
Manufacturer
Available Country
Last Updated: September 19, 2023 at 7:00 am
Benflumetol
Benflumetol

Uses

Benflumetol is an antimalarial agent used in combination with artemether for the treatment of acute uncomplicated malaria caused by Plasmodium falciparum.

Benflumetol and artemether combination therapy is indicated for the treatment of acute uncomplicated malaria caused by Plasmodium falciparum, including malaria acquired in chloroquine-resistant areas. May also be used to treat uncomplicated malaria when the Plasmodium species has not been identified. Indicated for use in adults and children greater than 5 kg.

Benflumetol is also used to associated treatment for these conditions: Uncomplicated Malaria caused by Plasmodium falciparum

How Benflumetol works

The exact mechanism by which lumefantrine exerts its antimalarial effect is unknown. However, available data suggest that lumefantrine inhibits the formation of β-hematin by forming a complex with hemin and inhibits nucleic acid and protein synthesis.

Toxicity

Common side effects of combination artemether/lumefantrine therapy in adults include headache, anorexia, dizziness, and asthenia. Common side effects in children include pyrexia, cough, vomiting, anorexia, and headache. Possible serious adverse effects include QT prolongation, bullous eruption, urticaria, splenomegaly (9%), hepatomegaly (adults, 9%; children, 6%), hypersensitivty reaction, and angioedema.

Food Interaction

  • Avoid grapefruit products.
  • Take with food. Food increases absorption.

Elimination Route

Food increases absorption.

Half Life

~ 4.5 days

Innovators Monograph

You find simplified version here Benflumetol

http://classyfire.wishartlab.com/tax_nodes/C0000000
http://classyfire.wishartlab.com/tax_nodes/C0002448
http://classyfire.wishartlab.com/tax_nodes/C0000020
http://classyfire.wishartlab.com/tax_nodes/C0000020
http://classyfire.wishartlab.com/tax_nodes/C0001099
http://classyfire.wishartlab.com/tax_nodes/C0003899
http://classyfire.wishartlab.com/tax_nodes/C0001030
http://classyfire.wishartlab.com/tax_nodes/C0002239
http://classyfire.wishartlab.com/tax_nodes/C0001661
http://classyfire.wishartlab.com/tax_nodes/C0001897
http://classyfire.wishartlab.com/tax_nodes/C0004557
http://classyfire.wishartlab.com/tax_nodes/C0001516
http://classyfire.wishartlab.com/tax_nodes/C0004150
http://classyfire.wishartlab.com/tax_nodes/C0003073
https://www.ebi.ac.uk/chebi/searchId.do?chebiId=CHEBI:156095
http://www.hmdb.ca/metabolites/HMDB0015653
http://www.genome.jp/dbget-bin/www_bget?drug:D03821
https://pubchem.ncbi.nlm.nih.gov/summary/summary.cgi?cid=6437380
https://pubchem.ncbi.nlm.nih.gov/summary/summary.cgi?sid=99443260
https://www.chemspider.com/Chemical-Structure.4941944.html
http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50238630
https://mor.nlm.nih.gov/RxNav/search?searchBy=RXCUI&searchTerm=847728
https://www.ebi.ac.uk/chebi/searchId.do?chebiId=156095
https://www.ebi.ac.uk/chembldb/index.php/compound/inspect/CHEMBL38827
http://www.pharmgkb.org/drug/PA165111722
http://www.rxlist.com/coartem-drug.htm
https://www.drugs.com/pro/coartem.html
https://en.wikipedia.org/wiki/Lumefantrine
*** Taking medicines without doctor's advice can cause long-term problems.
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