Benoxinate Hydrochloride 0.4%

Benoxinate Hydrochloride 0.4% Uses, Dosage, Side Effects, Food Interaction and all others data.

Benoxinate Hydrochloride 0.4% is a local anaesthetic. It may be less irritating than tetracaine, and the onset and duration of action are similar to tetracaine. Benoxinate Hydrochloride 0.4% binds to sodium channel and reversibly stabilizes the neuronal membrane which decreases its permeability to sodium ions. Depolarization of the neuronal membrane is inhibited thereby blocking the initiation and conduction of nerve impulses.

Benoxinate Hydrochloride 0.4% is a local anaesthetic. It may be less irritating than tetracaine, and the onset and duration of action are similar to tetracaine.

Benoxinate Hydrochloride 0.4%
Uses
Dosage
Side Effect
Precautions
Interactions
Uses during Pregnancy
Uses during Breastfeeding
Accute Overdose
Food Interaction
Half Life
Volume of Distribution
Clearance
Interaction With other Medicine
Contradiction
Storage

Trade Name	Benoxinate Hydrochloride 0.4%
Generic	Oxybuprocaine
Oxybuprocaine Other Names	Benoxinate, Oxibuprocaina, Oxybucaine, Oxybuprocaine, Oxybuprocainum, Oxyriprocaine
Type
Formula	C₁₇H₂₈N₂O₃
Weight	Average: 308.4158 Monoisotopic: 308.209992772
Groups	Approved, Investigational
Therapeutic Class	Ocular perioperative drugs
Manufacturer
Available Country	Japan
Last Updated:	September 19, 2023 at 7:00 am

Uses

Used to temporarily numb the front surface of the eye so that the eye pressure can be measured or a foreign body removed.

Benoxinate Hydrochloride 0.4% is also used to associated treatment for these conditions: Local Anesthesia of the Mouth

How Benoxinate Hydrochloride 0.4% works

Benoxinate Hydrochloride 0.4% binds to sodium channel and reversibly stabilizes the neuronal membrane which decreases its permeability to sodium ions. Depolarization of the neuronal membrane is inhibited thereby blocking the initiation and conduction of nerve impulses.

Dosage

Benoxinate Hydrochloride 0.4% dosage

Use as a 0.4% solution in short ophthalmic procedures. Instil 1 drop into the conjunctival sac to allow tonometry after 60 sec; a further drop after a 90 sec interval produces sufficiReduce systemic absorption by compressing the lacrimal sac at the medial canthus for a minute during and following instillation. Heart block; epilepsy, impaired cardiac conduction, myasthenia gravis; not to be applied to inflamed, infected tissues or damaged mucosa. Protect anaesthetised eye from dust and bacterial contamination; cornea may be damaged by prolonged application. Do not drive until normal vision restored.ent anaesthesia for the fitting of contact lenses; 3 drops at 90 sec intervals produces sufficient anaesthesia after 5 min for a foreign body to be removed from the corneal epithelium or for incision of a meibomian cyst through the conjunctiva.

Side Effects

Hypersensitivity reactions; transient stinging and blurring of vision; excitation of CNS; muscle twitching and tremors; convulsions.

Precaution

Reduce systemic absorption by compressing the lacrimal sac at the medial canthus for a minute during and following instillation. Heart block; epilepsy, impaired cardiac conduction, myasthenia gravis; not to be applied to inflamed, infected tissues or damaged mucosa. Protect anaesthetised eye from dust and bacterial contamination; cornea may be damaged by prolonged application. Do not drive until normal vision restored.

Food Interaction

No interactions found.

Pregnancy & Breastfeeding use

Pregnancy Category C. Either studies in animals have revealed adverse effects on the foetus (teratogenic or embryocidal or other) and there are no controlled studies in women or studies in women and animals are not available. Drugs should be given only if the potential benefit justifies the potential risk to the foetus.