Benzhydroflumethiazide
Benzhydroflumethiazide Uses, Dosage, Side Effects, Food Interaction and all others data.
A thiazide diuretic with actions and uses similar to those of hydrochlorothiazide. It has been used in the treatment of familial hyperkalemia, hypertension, edema, and urinary tract disorders. (From Martindale, The Extra Pharmacopoeia, 30th ed, p810)
Benzhydroflumethiazide, a thiazide diuretic, removes excess water from the body by increasing how often you urinate (pass water) and also widens the blood vessels which helps to reduce blood pressure. It inhibits Na+/Cl- reabsorption from the distal convoluted tubules in the kidneys. Thiazides also cause loss of potassium and an increase in serum uric acid. Thiazides are often used to treat hypertension, but their hypotensive effects are not necessarily due to their diuretic activity. Thiazides have been shown to prevent hypertension-related morbidity and mortality although the mechanism is not fully understood. Thiazides cause vasodilation by activating calcium-activated potassium channels (large conductance) in vascular smooth muscles and inhibiting various carbonic anhydrases in vascular tissue.
| Trade Name | Benzhydroflumethiazide |
| Availability | Prescription only |
| Generic | Bendroflumethiazide |
| Bendroflumethiazide Other Names | Bendrofluazide, Bendroflumethiazid, Bendrofluméthiazide, Bendroflumethiazide, Bendroflumethiazidum, Bendroflumetiazida, Benzhydroflumethiazide |
| Related Drugs | amlodipine, lisinopril, metoprolol, losartan, furosemide, hydrochlorothiazide, spironolactone, Lasix, chlorthalidone, torsemide |
| Type | |
| Formula | C15H14F3N3O4S2 |
| Weight | Average: 421.415 Monoisotopic: 421.037781946 |
| Protein binding | 96% |
| Groups | Approved |
| Therapeutic Class | |
| Manufacturer | |
| Available Country | |
| Last Updated: | September 19, 2023 at 7:00 am |
Uses
Benzhydroflumethiazide is a diuretic used to suppress lactation and to treat hypertension and edema.
For the treatment of high blood pressure and management of edema related to heart failure.
Benzhydroflumethiazide is also used to associated treatment for these conditions: High Blood Pressure (Hypertension)
How Benzhydroflumethiazide works
As a diuretic, bendroflumethiazide inhibits active chloride reabsorption at the early distal tubule via the Na-Cl cotransporter, resulting in an increase in the excretion of sodium, chloride, and water. Thiazides like bendroflumethiazide also inhibit sodium ion transport across the renal tubular epithelium through binding to the thiazide sensitive sodium-chloride transporter. This results in an increase in potassium excretion via the sodium-potassium exchange mechanism. The antihypertensive mechanism of bendroflumethiazide is less well understood although it may be mediated through its action on carbonic anhydrases in the smooth muscle or through its action on the large-conductance calcium-activated potassium (KCa) channel, also found in the smooth muscle.
Food Interaction
- Take with food. Food increases bioavailability.
Benzhydroflumethiazide Alcohol interaction
[Moderate]
Many psychotherapeutic and CNS-active agents (e.g., anxiolytics, sedatives, hypnotics, antidepressants, antipsychotics, opioids, alcohol, muscle relaxants) exhibit hypotensive effects, especially during initiation of therapy and dose escalation.
Coadministration with antihypertensives and other hypotensive agents, in particular vasodilators and alpha-blockers, may result in additive effects on blood pressure and orthostasis.
Caution and close monitoring for development of hypotension is advised during coadministration of these agents.
Some authorities recommend avoiding alcohol in patients receiving vasodilating antihypertensive drugs.
Patients should be advised to avoid rising abruptly from a sitting or recumbent position and to notify their physician if they experience dizziness, lightheadedness, syncope, orthostasis, or tachycardia.
Benzhydroflumethiazide Cholesterol interaction
[Moderate] Thiazide diuretics may increase serum triglyceride and cholesterol levels, primarily LDL and VLDL.
Whether these effects are dose-related and sustained during chronic therapy are unknown.
Patients with preexisting hyperlipidemia may require closer monitoring during thiazide therapy, and adjustments made accordingly in their lipid-lowering regimen
Benzhydroflumethiazide Drug Interaction
Moderate: albuterol, albuterol, cholecalciferol, cholecalciferolUnknown: aspirin, aspirin, amoxicillin / clavulanate, amoxicillin / clavulanate, sulfamethoxazole / trimethoprim, sulfamethoxazole / trimethoprim, atorvastatin, atorvastatin, acetaminophen, acetaminophen, multivitamin, multivitamin, cyanocobalamin, cyanocobalamin, ascorbic acid, ascorbic acid
Benzhydroflumethiazide Disease Interaction
Major: anuria, electrolyte losses, liver disease, lupus erythematosus, renal function disordersModerate: asthma, diabetes, hyperlipidemia, hyperparathyroidism, hyperuricemia, thyroid function tests
Elimination Route
Absorbed relatively rapidly after oral administration
Half Life
8.5 hours
Innovators Monograph
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