Benzylbenzoate ointment 10%
Benzylbenzoate ointment 10% Uses, Dosage, Side Effects, Food Interaction and all others data.
Benzyl benzoate is an acaricide that is used in the treatment of scabies. Benzyl benzoate exerts toxic effects on the nervous system of the parasite, resulting in its death. It is also toxic to mite ova, though its exact mechanism of action is unknown. In vitro, benzyl benzoate has been found to kill the Sarcoptes mite within 5 minutes.
Benzyl benzoate is one of the older preparations used to treat scabies. Scabies is a skin infection caused by the mite sarcoptes scabiei. It is characterised by severe itching (particularly at night), red spots, and may lead to a secondary infection. Benzyl benzoate is lethal to this mite and so is useful in the treatment of scabies. It is also used to treat lice infestation of the head and body. Benzyl benzoate is not the treatment of choice for scabies due to its irritant properties.
| Trade Name | Benzylbenzoate ointment 10% |
| Generic | Benzyl Benzoate |
| Benzyl Benzoate Other Names | Acarobenzyl, Benylate, Benzevan, Benzoate de benzyle, Benzoesäurebenzylester, Benzoic acid phenylmethylester, Benzyl benzoat, Benzyl benzoate, Benzylis benzoas, Phenylmethyl benzoate |
| Type | |
| Formula | C14H12O2 |
| Weight | Average: 212.2439 Monoisotopic: 212.083729628 |
| Groups | Approved |
| Therapeutic Class | Parasiticidal preparations, Topical Antifungal preparations |
| Manufacturer | |
| Available Country | Russia |
| Last Updated: | September 19, 2023 at 7:00 am |
How Benzylbenzoate ointment 10% works
Benzyl benzoate exerts toxic effects on the nervous system of the parasite, resulting in its death. It is also toxic to mite ova, though its exact mechanism of action is unknown. In vitro, benzyl benzoate has been found to kill the Sarcoptes mite within 5 minutes.
Dosage
Benzylbenzoate ointment 10% dosage
Adult:Apply 3 times at 12 hourly intervals over the whole body, wash-off 12 hr after the last application.
Side Effects
Irritant to eyes and mucous membranes, allergic dermatitis reactions, drying effects in the elderly.
Toxicity
Oral, rabbit: LD50 = 1680 mg/kg; Skin, rabbit: LD50 = 4000 mg/kg. Symptoms of overdose include blister formation, crusting, itching, oozing, reddening, or scaling of skin; difficulty in urinating (dribbling); jerking movements; sudden loss of consciousness.
Precaution
Prevent drug from entering the eyes, elderly (drying effects).
Interaction
Irritant to eyes and mucous membranes, allergic dermatitis reactions, drying effects in the elderly.
Elimination Route
No data are available on percutaneous absorption of benzyl benzoate. Some older studies have suggested some percutaneous absorption, however the amount was not quantified.
Pregnancy & Breastfeeding use
Pregnancy Category: Not Classified. FDA has not yet classified the drug into a specified pregnancy category.
Contraindication
Broken or irritated skin; neonates; pregnancy.
Storage Condition
Store below 25°C.
Innovators Monograph
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Benzylbenzoate ointment 10% contains Benzyl Benzoate see full prescribing information from innovator Benzylbenzoate ointment 10% Monograph, Benzylbenzoate ointment 10% MSDS, Benzylbenzoate ointment 10% FDA label
