Bezitramide
Bezitramide Uses, Dosage, Side Effects, Food Interaction and all others data.
Bezitramide is a narcotic analgesic which was discovered in 1961, clinically tested around the 1970's , and marketed under the name Burgodin. After cases of fatal overdose in the Netherlands in 2004 the drug was withdrawn from the market.
Bezitramide has never been FDA approved and is currently a schedule II drug.
Bezitramide acts in the body to relieve pain with a potency 20 times that of methadone . Its duration of action is relatively long, lasting up to 12 hours post oral administration, after the achievement of steady state. Its onset of action is slow, with a peak in analgesic effect noted between 2.5-3.5 hours after dosing.
| Trade Name | Bezitramide |
| Generic | Bezitramide |
| Bezitramide Other Names | Bezitramida, Bezitramide, Bezitramidum |
| Type | |
| Formula | C31H32N4O2 |
| Weight | Average: 492.6114 Monoisotopic: 492.252526288 |
| Groups | Experimental, Illicit, Withdrawn |
| Therapeutic Class | |
| Manufacturer | |
| Available Country | |
| Last Updated: | September 19, 2023 at 7:00 am |
Uses
A narcotic analgesic once used for the treatment of severe chronic pain.
Elimination Route
Bezitramide has poor water solubility, thus administration is restricted to the oral route.
Half Life
11-24h.
Elimination Route
Less than 0.3% of the dose was excreted unchanged in the urine. High concentrations in feces suggested incomplete absorption of biliary excretion.
Experiments in rats demonstrated extensive (up to 70%) biliary excretion, and less than 3% urinary excretion.
Innovators Monograph
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