Big Plus
Big Plus Uses, Dosage, Side Effects, Food Interaction and all others data.
Big Plus is the neurologically active form of vitamin B12 and occurs as a water-soluble vitamin in the body. It is a cofactor in the enzyme methionine synthase, which functions to transfer methyl groups for the regeneration of methionine from homocysteine. In anaemia, it increases erythrocyte production by promoting nucleic acid synthesis in the bone marrow and by promoting maturation and division of erythrocytes.
| Trade Name | Big Plus |
| Generic | Mecobalamin |
| Mecobalamin Other Names | Co-methylcobalamin, MeCbl, Mecobalamin, Mecobalamina, Mecobalaminum, Methyl vitamin B12, Methyl(III)cobalamin, Methylcobalamin |
| Weight | methylcobalamin |
| Type | Injection, Syrup |
| Formula | C63H91CoN13O14P |
| Weight | Average: 1344.3823 Monoisotopic: 1343.587806391 |
| Groups | Approved, Investigational |
| Therapeutic Class | Drugs for Megaloblastic Anemia |
| Manufacturer | Lanark Laborotories |
| Available Country | India |
| Last Updated: | September 19, 2023 at 7:00 am |
Uses
Big Plus is used for-
- Peripheral Neuropathies
- Diabetic Neuropathy
- Verteberal Syndrome
- Nerve Compression Syndrome
- Multiple sclerosis
- Amyotrophic lateral sclerosis
- Parkinson’s disease
- Alzheimer’s disease
- Diabetic retinopathy
- Entrapment neuropathy
- Drug induced neuropathy
- Megaloblastic anemia due to Vitamin B12 deficiency
Big Plus is also used to associated treatment for these conditions: Vitamin B12 Deficiency, Nutritional supplementation
Dosage
Big Plus dosage
Tablet: The usual adult dosage is one 500 mcg tablet three times daily. The dosage should be adjusted according to the age of patient and the severity of symptoms.
Injection:
- Peripheral neuropathies: The usual adult dosage is one ampoule equivalent to 500 mcg of Big Plus, administered intramuscularly or intravenously three times a week.The dosage should be adjusted according to the age of patient and the severity of symptoms.
- Megaloblastic anemia: The usual adult dosage is one ampoule equivalent to 500 mcg of Big Plus, administered intramuscularly or intravenously three times a week. After about two months of administration, dosage should be changed to one ampoule equivalent to 500 mcg of Big Plus every one to three months as maintenance therapy
Side Effects
Generally Big Plus is well tolerated. However, a few side effects like GI discomfort (including anorexia, nausea or diarrhea) & rash may be seen after administration of Big Plus.
Precaution
The medicine should not be used for months if there is no response at all after its use for a certain period of time.
Interaction
Decreased GI tract absorption with neomycin, aminosalicylic acid, H2-blockers and colchicine. Reduced serum concentrations with oral contraceptives. Reduced effects in anaemia with parenteral chloramphenicol.
Food Interaction
No interactions found.Pregnancy & Breastfeeding use
Not recommended during pregnancy & lactation.
Contraindication
Hypersensitivity to any component of this product.
Special Warning
Use in children: Not recommended.
Storage Condition
Oral: Store at room temperature. Protect from moisture and light.
Parenteral: Store at room temperature. Do not expose to direct light.
Innovators Monograph
You find simplified version here Big Plus
FAQ
What is Big Plus used for?
Big Plus is used to treat vitamin B12 deficiency.
How safe is Big Plus?
Big Plus is considered likely safe when used appropriately.
How does Big Plus work?
Big Plus works by functioning in the production of a compound called myelin, which covers and protect nerve fibers.
What are the common side effects of Big Plus?
Common side effects of Big Plus are include:
- Nausea.
- Vomiting.
- Diarrhea.
- Loss of appetite.
- Headache.
Is Big Plus safe during pregnancy?
Pregnancy There are no data available for Big Plus to be used in pregnant women.
Is Big Plus safe during breastfeeding?
There are no data available for Big Plus to be used in lactating women.
Can I drink alcohol with Big Plus?
No interactions were found between Alcohol and Big Plus. This does not necessarily mean no interactions exist. Always consult your healthcare provider.
Can I take Big Plus daily?
The recommended dose is 500 mcg three times daily or 1500 mcg daily. Most generic vitamins contain cyanocobalamin, which may not be as effective or as beneficial.
How much Big Plus should I take?
The general recommendation for adults is 2.4 mcg. Older adults, as well as pregnant and breastfeeding women, require higher doses.
Should I take Big Plus on an empty stomach?
It is a well-known medical fact that water-soluble vitamins are better absorbed on an empty stomach. So, the usual time of taking Big Plus will be in the morning as the first dose, half an hour before lunch, and 2 hours post a meal.
How long does Big Plus take to work?
With brisk development of new red blood cells, a response is typically seen within 48 to 72 hours. Big Plus supplies have reached normal levels,Big Plus injections will be required every one to three months to avoid the return of symptoms.
How long does Big Plus supplements stay in my system?
Other studies have shown that Big Plus has a half-life of around six days in the blood, which means that it would take six days before half of the administered amount is excreted from the body
Can Big Plus damage my liver?
There is no evidence that the other B vitamins, in physiologic or even super-physiologic high doses cause liver injury or jaundice.
What are the symptoms of high Big Plus levels?
The study found that high doses of these Big Plus were actually harmful.
Can Big Plus cause kidney stones?
Big Plus have not been shown to be harmful to people with kidney stones.
How long Big Plus can be taken?
Big Plus for 2-4 weeks is associated with better outcome in nerve conduction velocity and neuropathic symptoms.
Who should not take Big Plus?
You should not use Big Plus if you are allergic to Big Plus or cobalt. Tell your doctor if you have ever had Leber's disease or other form of optic nerve damage,an iron or folic acid deficiency.
What happens if I miss a dose of Big Plus?
Use Big Plus as soon as you can, but skip the missed dose if it is almost time for your next dose. Do not use two doses at one time.
Can I overdose on Big Plus?
You cannot overdose on Big Plus because any excess you simply pee out. If you get Big Plus shots, you may experience side effects like dizziness, nausea, and fatigue.
