Biocerine Gm
Biocerine Gm Uses, Dosage, Side Effects, Food Interaction and all others data.
Glucosamine is a natural substance produced in the human body and found in certain foods. Glucosamine stimulates the production of glycosaminoglycan & proteoglycan, two essential building blocks of cartilage. Glucosamine acts, as a supplement, as a joint lubricant and shock absorber necessary to maintain healthy cartilage and joint function.
Diacerein is an anti-inflammatory analgesic and antipyretic drug, indicated specially for the treatment of arthritic conditions. It directly inhibits IL-1 synthesis and release in vitro and down modulates IL-1 induced activities and relieves Osteoarthritis.
Trade Name | Biocerine Gm |
Generic | Diacerein + Glucosamine Sulphate |
Type | Tablet |
Therapeutic Class | Stimulation of Cartilage formation |
Manufacturer | Biocin Genetics And Pharma |
Available Country | India |
Last Updated: | September 19, 2023 at 7:00 am |
Uses
This is primarily used for conditions like Osteoarthritis, Rheumatoid arthritis, Bone & Joint injuries.
Biocerine Gm is also used to associated treatment for these conditions: Osteoarthritis in the Hip Joint, Osteoarthritis of the Knee
How Biocerine Gm works
Diacerein's active metabolite rhein Rhein reduces cartilage destruction by decreasing expression of matrix metalloproteinase (MMP)-1 and -3 as well as upregulating tissue inhibitor of matrix metalloproteinases which serve to reduce the activity of several MMPs . The anti-inflammatory action of rhein reduces the level of interleukin-1beta activity which plays a large role in reduction of extracellular matrix production, MMP activity, and continued inflammation . Rhein reduces abnormal osteoblast synthetic activity through an unknown mechanism .
Dosage
Biocerine Gm dosage
Adult & Children above 12 years: One tablet (Diacerein50 mg & Glucosamine Sulphate750 mg) twice daily for 4-12 weeks, taken with food.
Creatinine Clearance(CrCl) < 30 ml/min: The dose of Diacerein to be reduced.
Side Effects
Diarrhea, constipation, epigastric pain, heart burn, nausea, vomiting, headache, skin rashes, drowsiness, intense yellow coloring of urine.
Toxicity
Rhein Rhein has an oral LD50 of >5000mg/kg in mice. This is equivalent to a diacerein dose of >6476mg/kg.
Precaution
Caution should be practiced when administering Glucosamine + Diacerein in those patients who are allergic to Glucosamine and/or Diacerein or to shellfish (e.g., shrimp, crab); who have diabetes, asthma, alcohol dependence or liver disease. Before taking Glucosamine + Diacerein complete blood count, liver function and urinalysis should be monitored regularly.
Interaction
There have been no reports of significant drug interactions of Glucosamine with antibiotics/ antidepressants/ antihypertensives/ nitrates/ antiarrythmics/ anxiolytic/ hypoglycemic agents/ antisecretives. But decreased absorption of Diacerein with aluminium and/ or magnesium hydroxide antacids. Increased risk of diarrhea with laxatives, antibiotics. Avoid co-administration with fibres and phytic acids.
Volume of Distribution
15-60L .
Elimination Route
Bioavailability of 50-60% . Entirely converted to the active metabolite rhein Rhein before reaching systemic circulation.
Half Life
4-10h .
Clearance
Total CL is 1.5L/h and renal CL is 0.1L/h .
Elimination Route
37% excreted in urine and 53% in feces as estimated in rats .
Pregnancy & Breastfeeding use
Diacerein is contraindicated in pregnancy and lactation. Glucosamine should not be taken by pregnant women and nursing mothers due to lack of scientific data regarding its effect on fetus and infants.
Contraindication
There are no known contraindications for Glucosamine. But proven hypersensitivity to Glucosamine is a contraindication. Diabetics are advised to monitor blood glucose levels regularly when taking Glucosamine. No special studies were formed in patients with renal and/or hepatic insufficiency. The toxicological and pharmacokinetic profile of Glucosamine does not indicate limitations for these patients. However, administration to patients with severe hepatic or renal insufficiency should be under appropriate medical supervision. Children should not be supplemented with Glucosamine. Diacerein or to shellfish (e.g., shrimp, crab); who have diabetes, asthma, alcohol dependence or liver disease. While taking the drug complete blood count, liver function and urinalysis should be monitored regularly. Diacerein is contraindicated in pregnancy, lactation and hypersensitivity to anthraquinone derivatives.
Acute Overdose
Diarrhea may occur.
Storage Condition
Store in a cool & dry place, protect from light & moisture.
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