Biophin Im

Biophin Im Uses, Dosage, Side Effects, Food Interaction and all others data.

Biophin Im is a sterile, semisynthetic, broad-spectrum, 3rd generation cephalosporin antibiotic for intravenous or intramuscular administration. The bactericidal activity of Biophin Im results from inhibition of cell wall synthesis. Biophin Im has a high degree of stability in the presence of beta-lactamases both penicillinases and cephalosporinases of gram-negative and gram- positive bacteria.

Biophin Im is a cephalosporin/cephamycin beta-lactam antibiotic used in the treatment of bacterial infections caused by susceptible, usually gram-positive, organisms. Biophin Im has in vitro activity against gram-positive aerobic, gram-negative aerobic, and anaerobic bacteria. The bactericidal activity of ceftriaxone results from the inhibition of cell wall synthesis and is mediated through ceftriaxone binding to penicillin-binding proteins (PBPs). Biophin Im is stable against hydrolysis by a variety of beta-lactamases, including penicillinases, and cephalosporinases and extended-spectrum beta-lactamases. However, resistance to ceftriaxone usually occurs through beta-lactamase hydrolysis, altered PBPs, or reduced bacterial cell permeability. Biophin Im should not be mixed with or giving in the same IV line as diluents/products containing calcium as they may cause ceftriaxone to precipitate. Biophin Im use may also cause biliary sludge or gallbladder pseudolithiasis.

Trade Name Biophin Im
Availability Prescription only
Generic Ceftriaxone
Ceftriaxone Other Names Ceftriaxona, Ceftriaxone, Ceftriaxonum, Rocephin
Related Drugs amoxicillin, doxycycline, diclofenac ophthalmic, ciprofloxacin, cephalexin, metronidazole, azithromycin, clindamycin, dexamethasone ophthalmic, levofloxacin
Weight Ig
Type Powder For Injection
Formula C18H18N8O7S3
Weight Average: 554.58
Monoisotopic: 554.04605704
Protein binding

Ceftriaxone is 95% protein bound.

Groups Approved
Therapeutic Class Third generation Cephalosporins
Manufacturer Intracin Pharmaceutical Pvt Limited
Available Country India, Nigeria
Last Updated: September 19, 2023 at 7:00 am
Biophin Im
Biophin Im

Uses

Biophin Im is used for the treatment of the following infections when caused by susceptible organisms:

Lower Respiratory Tract Infections caused by Streptococcus pneumoniae, Staphylococcus aureus, Haemophilus influenzae, Haemophilus parainfluenzae, Klebsiella pneumoniae, E. coli, Enterobacter aerogenes, Proteus mirabilis, Serratia marcescens.

Acute Bacterial Otitis Media caused by Streptococcus pneumoniae, Haemophilus influenzae (including beta-lactamase producing strains), Moraxella catarrhalis (including beta-lactamase producing strains).

Skin and Skin Structure Infections caused by Staphylococcus aureus, Staphylococcus epidermidis, Streptococcus pyogenes, Viridans group streptococci, E. coli, Enterobacter cloacae, Klebsiella oxytoca, Klebsiella pneumoniae, Proteus mirabilis, Morganella morganii, Pseudomonas aeruginosa, Serratia marcescens, Acinetobacter calcoaceticus, Bacteroides fragilis, Peptostreptococcus species.

Urinary Tract Infections (complicated and uncomplicated) caused by E. coli, Proteus mirabilis, Proteus vulgaris, Morganella morganii, Klebsiella pneumoniae.

Uncomplicated Gonorrhea (cervical, urethral, pharyngial and rectal) caused by Neisseria gonorrhoeae, including both penicillinase- and nonpenicillinase-producing strains, and pharyngeal gonorrhea caused by nonpenicillinase-producing strains of Neisseria gonorrhoeae.

Pelvic Inflammatory Disease caused by Neisseria gonorrhoeae.

Bacterial Septicemia caused by Staphylococcus aureus, Streptococcus pneumoniae, E. coli, Haemophilus influenzae, Klebsiella pneumoniae.

Bone and Joint Infections caused by Staphylococcus aureus, Streptococcus pneumoniae, E. coli, Proteus mirabilis, Klebsiella pneumoniae, Enterobacter species.

Intra-abdominal Infections caused by E. coli, Klebsiella pneumoniae, Bacteroides fragilis, Clostridium species, Peptostreptococcus species.

Meningitis caused by Haemophilus influenzae, Neisseria meningitidis, Streptococcus pneumoniae. Biophin Im has also been used successfully in a limited number of cases of meningitis and shunt infection caused by Staphylococcus epidermidis and E. coli.

Surgical Prophylaxis: The preoperative administration of a single 1 gm dose of Biophin Im may reduce the incidence of postoperative infections in patients undergoing surgical procedures classified as contaminated or potentially contaminated.

Biophin Im is also used to associated treatment for these conditions: Arthritis gonococcal, Bacterial Endocarditis, Bacterial Infections, Bacterial Sepsis, Bacterial Sinusitis, Bone and Joint Infections, Brain abscess, Chancroid, Community Acquired Pneumonia (CAP), Conjunctivitis gonococcal neonatal, Epididymitis, Epiglottitis, Gonococcal infection of pharynx, Gonococcal pelvic inflammatory disease, Intra-Abdominal Infections, Lower respiratory tract infection bacterial, Lyme Neuroborreliosis, Meningitis, Bacterial, Ophthalmia neonatorum due to gonococcus, Postoperative Infections, Prosthetic Joint Infection, Salmonella Typhi Infection, Septic Arthritis, Shigellosis, Skin and Subcutaneous Tissue Bacterial Infections, Syphilis, Vulvovaginitis gonococcal, Whipple Disease, Bacterial otitis media, Complicated Bacterial Urinary Tract Infections, Susceptible Bacterial Infections, Uncomplicated Gonorrhea, Uncomplicated Urinary tract infection bacterial

How Biophin Im works

Biophin Im works by inhibiting the mucopeptide synthesis in the bacterial cell wall. The beta-lactam moiety of ceftriaxone binds to carboxypeptidases, endopeptidases, and transpeptidases in the bacterial cytoplasmic membrane. These enzymes are involved in cell-wall synthesis and cell division. Binding of ceftriaxone to these enzymes causes the enzyme to lose activity; therefore, the bacteria produce defective cell walls, causing cell death.

Dosage

Biophin Im dosage

Generally, Biophin Im should be taken once or equally devided twice a day for 4-14 days. Biophin Im therapy should be continued for at least 2 days after the sign and symptoms of infection have disappeared.

The usual duration of therapy is 4 to 14 days; in complicated infections longer therapy may be required. No dosage adjustment is required for patients with renal or hepatic impairment.

Use the solution immediately after reconstitution of powder.

Side Effects

Generally Biophin Im is well tolerated. However, few side effects including nausea, vomiting, diarrhea, dizziness and fever may occur.

Toxicity

Biophin Im overdose may increase the risk of urolithiasis and subsequent post-renal acute renal failure (PARF). Other symptoms of overdose unavailable in the literature. However, they are likely similar to the adverse effects of the medication. If overdose of ceftriaxone occurs, treat with symptomatic and supportive treatment, as ceftriaxone levels will not be reduced by dialysis.

Precaution

Biophin Im should be administered with caution to individuals with a history of gastrointestinal disease, particularly colitis.

Interaction

May increase nephrotoxicity of aminoglycosides. May diminish therapeutic effect of BCG, typhoid vaccine, Na picosulfate. May increase anticoagulant effect of vit K antagonists (e.g. warfarin). May increase serum level with probenecid.

Food Interaction

No interactions found.

Volume of Distribution

The apparent volume of distribution of an intravenous or intramuscular dose in healthy patients is 5.78 to 13.5 L. The volume of distribution of an intravenous or intramuscular dose in septic patients is 6.48 to 35.2 L. Biophin Im has good enough CSF penetration to be used as an effective treatment of bacterial meningitis.

Elimination Route

Biophin Im is only given as an injection, either intramuscularly or intravenously. Biophin Im is less than 1% bioavailable if given orally.

Half Life

The elimination half-life of ceftriaxone is 5.8-8.7 hours. The half-life of ceftriaxone in the middle ear fluid has been estimated to be 25 hours.

Clearance

The plasma clearance of ceftriaxone in healthy adults receiving a 0.15-3g dose is 0.58 to 1.45 L/hour. The renal clearance of ceftriaxone is 0.32 to 0.73 L/hour. In intensive care unit patients, ceftriaxone's total drug clearance was 0.96L/h (0.55-1.28 L/h), and unbound drug clearance was 1.91 L/h (1.46-6.20 L/h).

Elimination Route

Biophin Im is primarily eliminated in the urine (33-67%). The remainder is eliminated through secretion in the bile and removed from the body via the feces.

Pregnancy & Breastfeeding use

Pregnancy: The safety of Biophin Im in the treatment of infections during pregnancy has not been established. Biophin Im should only be used during pregnancy if the likely benefit outweighs the potential risk to the fetus and/or the mother.

Lactation: Biophin Im is excreted in breast milk at low concentrations. Therefore, caution should be exercised when Biophin Im is administered to a nursing mother.

Contraindication

Biophin Im should not be given to patients with a history of hypersensitivity to cephalosporin antibiotics. It is contraindicated in premature infants during the first 6 weeks of life. Its safety in human pregnancy has not been established. Biophin Im is contraindicated in neonates if they require (or are expected to require) treatment with calcium-containing IV solutions, including continuous calcium containing infusions such as parenteral nutrition because of the risk of precipitation of ceftriaxone-calcium.

Acute Overdose

There is no specific antidote. Treatment of over dosage should be symptomatic.

Storage Condition

Store below 25°C, protected from light & moisture. Use reconstituted solutions immediately.

Reconstituted solutions are stable for 6 hours at room temperature and for 24 hours at 2°-8°C. It should not be mixed in the same syringe with any drug other than 1% Lidocaine Hydrochloride injection BP (for IM injection only).

Innovators Monograph

You find simplified version here Biophin Im

Biophin Im contains Ceftriaxone see full prescribing information from innovator Biophin Im Monograph, Biophin Im MSDS, Biophin Im FDA label

FAQ

What is Biophin Im used for?

Biophin Im is used to treat certain kinds of bacterial infections. It will not work for colds, flu, or other viral infections.Biophin Im is a cephalosporin antibiotic.

What are the common side effects of Biophin Im?

Common side effects of Biophin Im include:

  • rash,
  • diarrhea,
  • nausea,
  • vomiting,
  • upset stomach,
  • blood clots,
  • dizziness,
  • headache,
  • pain or swelling in your tongue,
  • a lump where the medicine was injected,
  • sweating,
  • vaginal itching or discharge,
  • vaginal yeast infection,
  • anemia,
  • changes in taste, or
  • flushing.

How safe is Biophin Im?

FDA alert states that generally, fatalities have been associated with simultaneous administration of Biophin Im and calcium-containing products.administration of the two products at different times and via different infusion lines has also been fatal.

Who should not take Biophin Im?

A type of blood disorder where the red blood cells burst called hemolytic anemia. Liver problems. disease of the gallbladder. Severe renal impairment.

Is Biophin Im safe during pregnancy?

At first ,Biophin Im is not harmful for pregnant women.The U.S. Food and Drug Administration (FDA) considers Biophin Im a pregnancy Category B medicine, which means that it has not been studied in pregnant women. However, when studied in pregnant animals, Biophin Im showed no negative effects on unborn babies.

What are the benefits of Biophin Im?

Biophin Im is used to treat many kinds of bacterial infections, including severe or life-threatening forms such as E. coli, pneumonia, or meningitis.Biophin Im is also used to prevent infection in people having certain types of surgery.

Is Biophin Im safe during breastfeeding?

Biophin Im is acceptable in nursing mothers.

Can I take Biophin Im without food?

Medications can interact with certain foods. In some cases, this may be harmful and your doctor may advise you to avoid certain foods. In the case of Biophin Im, there are no specific foods that you must exclude from your diet when receiving this medication.

Which foods should be avoided during treatment with Biophin Im?

Foods that must be avoided while on antibiotic treatment include grapefruit, foods rich in calcium.

Can I drink alcohol after taking Biophin Im?

It is best not to drink alcohol for up to 48 hours after the injection.

How many days should Biophin Im injection be taken?

It is sometimes given as a single dose and sometimes given once or twice a day for 4-14 days, depending on the type of infection being treated.

How long can I take Biophin Im?

Biophin Im is sometimes given for up to 14 days. Read and carefully follow any Instructions for Use provided with your medicine.

Can I drive after taking Biophin Im ?

Biophin Im can cause dizziness. If you feel dizzy, do not drive or use any tools or machines.

How does Biophin Im work in the body?

Biophin Im works by interfering with the formation of bacterial cell walls. Biophin Im impairs the bonds that hold the bacterial cell wall together, which allows holes to appear in the cell walls.

Where is Biophin Im injected?

Biophin Im is injected into a muscle or as an infusion into a vein (IV).

Can I take Biophin Im without food?

In some cases, this may be harmful and your doctor may advise you to avoid certain foods. In the case of Biophin Im, there are no specific foods that you must exclude from your diet when receiving this medication.

*** Taking medicines without doctor's advice can cause long-term problems.
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