Biorub-I Hand Rub 75%+0.125%+1.45%

Biorub-I Hand Rub 75%+0.125%+1.45% Uses, Dosage, Side Effects, Food Interaction and all others data.

Isopropyl alcohol also known as isopropanol or IPA, is the most common and widely used disinfectant within pharmaceutics, hospitals, cleanrooms, and electronics or medical device manufacturing. It is a colorless, flammable chemical compound with a strong odor. 70% Isopropyl Alcohol is generally more effective at killing microorganisms and better tolerated than soap and water.Isopropyl Alcohol is an isomer of propyl alcohol with antibacterial properties. Although the exact mechanism of isopropanol's disinfecting action is not known, it might kill cells by denaturing cell proteins and DNA, interfering with cellular metabolism, and dissolving cell lipo-protein membranes. Isopropanol is used in soaps and lotions as an antiseptic. 70 % isopropyl alcohol solution kills microorganisms by dissolving plasma membrane of the cell wall.Glycerol: used as humectant, but other emollients may be used for skin care, provided that they are cheap, widely available and miscible in water and alcohol and do not add to toxicity, or promote allergy.Hydrogen peroxide: used to inactivate contaminating bacterial spores in the solution and is not an active substance for hand antisepsis.

Trade Name Biorub-I Hand Rub 75%+0.125%+1.45%
Generic Isopropyl Alcohol + Hydrogen Peroxide + Glycerol
Weight 75%+0.125%+1.45%
Type Hand Rub
Therapeutic Class Bleaching and Disinfectants
Manufacturer Biopharma Laboratories Ltd.
Available Country Bangladesh
Last Updated: October 19, 2023 at 6:27 am
Biorub-I Hand Rub 75%+0.125%+1.45%
Biorub-I Hand Rub 75%+0.125%+1.45%

Uses

This hand sanitizer is generally used to decrease infectious agents on the hands and is the most commonly used disinfectant in pharmaceutical industries. The important thing is that only 70% solution of isopropyl alcohol acts as a disinfectant killing all surface microorganisms. It is used to disinfect hands and equipment surface in pharmaceuticals.

Biorub-I Hand Rub 75%+0.125%+1.45% is also used to associated treatment for these conditions: Ear infection bacterial, Seborrheic Keratosis (SK), Excess ear wax, Superficial skin infectionsInfection, Preoperative Skin Preparation, Skin disinfection, Prophylaxis of bacterial skin infections

How Biorub-I Hand Rub 75%+0.125%+1.45% works

The production of free hydroxyl radicals in the Fenton reaction is thought to be the basis of biocidal actions of hydrogen peroxide. Free radicals eventually lead to oxidative damage proteins and membrane lipids in vivo . The oxidizing radical as the ferryl radical induces DNA oxidation .

Dosage

Biorub-I Hand Rub 75%+0.125%+1.45% dosage

Alcohol-based hand sanitizer is more convenient compared to hand washing with soap and water in most situations in the healthcare setting. It is generally more effective at killing microorganisms and better tolerated than soap and water. Alcohol-based hand sanitizer is recommended only if soap and water are not available. Using guideline is given bellow-

  1. Apply product to the palm of one hand.
  2. Rub hands together.
  3. Rub the product over all surfaces of hands and fingers until hands are dry.

To completely remove germs from hands wash your hand with this Anti-Germ Hand Wash for 20 seconds using the below WHO recommended 7 steps:

  • Step 1: Wet Hands. Wet your hands and apply enough liquid soap to create a good lather.
  • Step 2: Rub Palms Together.
  • Step 3: Rub the Back of Hands.
  • Step 4: Interlink Your Fingers.
  • Step 5: Cup Your Fingers.
  • Step 6: Clean the Thumbs.
  • Step 7: Rub Palms with Your Fingers.

Side Effects

Inhaling large amounts of isopropyl alcohol can cause nausea, vomiting, irritation of the nose and mucous membranes, throat irritations, and even difficulty with breathing as coughing can occur making it difficult for you to catch your breath. Isopropyl alcohol may cause burning, stinging, or a cold feeling where the medicine is applied.

Toxicity

Oral LD50 in mouse is 2000 mg/kg, and dermal LD50 is 4060 mg/kg in rat and 2000 mg/kg pig. LC50 of hydrogen peroxide vapours in rat is 2000 mg/m at 4 hours .

Oral ingestion of high dose hydrogen peroxide may cause chest and stomach pain, loss of consciousness, motor disorders, microhemorrhages and moderate leucocytosis in humans. Inhalation of highly concentrated vapours causes extreme irritation of nose and throat .

Hydrogen peroxide has no known carcinogenic potential. It was shown to be mutagenic to bacteria (Salmonella typhimurium) and the fungi, Neurospora crassa and Aspergillis chevallieri, and induced DNA damage in Escheria coli . It also caused sister chromatid exchanges and chromosomal aberrations in mammalian cells in vitro .

Precaution

Isopropyl Alcohol is highly flammable in the presence of heat, sparks, or an open flame. When handling isopropyl alcohol in a work environment (to best to avoid any contact with skin) protective clothing should be always be worn, including safety gloves and goggles. Isopropyl alcohol should be kept away from heat, sparks, flames and other sources of ignition, as well as strong oxidizers, acetaldehyde, chlorine, ethylene oxide, acids, and isocyanates. A flammable safety cabinet is the best storage option.

Interaction

If you are using this product under your doctor's direction, your doctor or pharmacist may already be aware of any possible drug interactions and may be monitoring you for them. Do not start, stop, or change the dosage of any medicine before checking with your doctor or pharmacist first. Keep a list of all your medications with you, and share the list with your doctor and pharmacist.

Volume of Distribution

Target organs affected by hydrogen peroxide include the lungs, intestine, thymus, liver, and kidney .

Elimination Route

It is reported that hydrogen peroxide is decomposed before absorption in the intestine. Solutions of hydrogen peroxide displays poor penetration when applied to tissue .

Pregnancy & Breastfeeding use

Hydrogen peroxide is safe to use during pregnancy. It is unlikely that this product passes into breast milk. Consult your doctor before breast-feeding.

Contraindication

Isopropyl Alcohol is contraindicated in patients with known Hypersensitivity.

Storage Condition

Isopropyl alcohol should be stored in a tightly closed container in a cool & dry place, protected from light, well-ventilated area. Due to the chemical's extreme flammability, it must be kept away from all possible ignition sources, including heat, sparks, and flames. Keep out of reach of children.

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*** Taking medicines without doctor's advice can cause long-term problems.
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