Bisacodyl-Grindeks
Bisacodyl-Grindeks Uses, Dosage, Side Effects, Food Interaction and all others data.
Bisacodyl-Grindeks works by stimulating enteric nerves to cause colonic contractions. It is also a contact laxative; it increases fluid and salt secretion. Action of bisacodyl on small intestine is negligible; stimulant laxatives mainly promote evacuation of the colon.
Patients should be counselled regarding abdominal pain, nausea, vomiting, or a change in bowel function that lasts longer than 2 weeks. It has a wide therapeutic index, as patients can take 5-15 mg orally. Patients taking bisacodyl should be counselled before taking the medication if they are already experiencing abdominal pain, nausea, vomiting, or a change in bowel function lasting longer than 2 weeks. Patients should also be counselled to stop taking the medication if they experience rectal bleeding or no bowel movement in 12 hours.
| Trade Name | Bisacodyl-Grindeks |
| Availability | Over the counter |
| Generic | Bisacodyl |
| Bisacodyl Other Names | Bisacodilo, Bisacodyl, Bisacodyle, Bisacodylum |
| Related Drugs | MiraLAX, erythromycin, Colace, docusate, Linzess, senna, magnesium oxide, polyethylene glycol 3350, Dulcolax, neomycin |
| Type | |
| Formula | C22H19NO4 |
| Weight | Average: 361.3906 Monoisotopic: 361.131408101 |
| Groups | Approved |
| Therapeutic Class | Stimulant purgatives |
| Manufacturer | |
| Available Country | Estonia, Georgia, Lithuania |
| Last Updated: | September 19, 2023 at 7:00 am |
Uses
Bisacodyl-Grindeks is used for Constipation; Preparation for radiography; antepartum & postpartum care; Preparation for sigmoidoscopy or proctoscopy; colonoscopy; hemorrhoids & anal fissures. All conditions which require defecation to be facilitated.
Bisacodyl-Grindeks is also used to associated treatment for these conditions: Constipation, Occasional Constipation, Bowel irregularity, Bowel preparation therapy
How Bisacodyl-Grindeks works
Bisacodyl-Grindeks is deacetylated to the active bis-(p-hydroxyphenyl)-pyridyl-2-methane (BHPM) by an intestinal deacetylase. BHPM can stimulate parasympathetic nerves in the colon directly to increase motility and secretions.
Bisacodyl-Grindeks stimulates adenylate cyclase, increasing cyclic AMP, leading to active transport of chloride and bicarbonate out of cells. Sodium ions, potassium ions, and water passively leave the cell; while sodium and chloride ions are unable to be reabsorbed.
Water is also be transported from the luminal side of cells into the vasculature by aquaporin 3. Bisacodyl-Grindeks decreases expression of aquaporin 3, preventing water from moving into the vasculature, which may contribute to increased water in the colon.
Bisacodyl-Grindeks directly stimulates parasympathetic nerves in the colon, stimulating contraction of longitudinal smooth muscle but not circular smooth muscle.
Dosage
Bisacodyl-Grindeks dosage
Constipation:
- Adult: 1-2 tab (5-10 mg) daily, relief in 6-12 hr.
- Adult/Pediatric: 1 suppository (10 mg) daily, relief in 15-30 min.
- Children <10 yr: 1 tab (5 mg) or 1 suppository (5 mg) daily.
For complete bowel clearance:
- >10 yr: 2-4 tab the night before & 1 adult suppository on the day of the procedure.
- <10 yr: 1 tab the night before & 1 pediatric suppositoryon the day of the procedure.
The max daily dose should not be exceeded.
Side Effects
Abdominal discomfort & diarrhea.
Toxicity
Patients experiencing an overdose of bisacodyl may present with more severe diarrhea and electrolyte imbalance. Patients should be treated with symptomatic and supportive measures.
The oral LD50 in rats is 4320 mg/kg, and in mice is 17500 mg/kg.
Precaution
Caution should be taken in pregnancy and children.
Interaction
Do not give antacids or milk within 1 hour of taking the drug (enteric coated)
Food Interaction
- Avoid milk and dairy products. Take at least 1 hour before or after antacids and milk.
- Take separate from antacids. Take at least 1 hour before or after antacids and milk.
Bisacodyl-Grindeks Drug Interaction
Moderate: furosemide, magnesium hydroxide, polyethylene glycol 3350, ondansetronUnknown: aspirin, lorazepam, diphenhydramine, docusate, duloxetine, omega-3 polyunsaturated fatty acids, sodium biphosphate / sodium phosphate, atorvastatin, pregabalin, metoprolol, acetaminophen / hydrocodone, acetaminophen, cyanocobalamin, ascorbic acid, cholecalciferol, cetirizine
Bisacodyl-Grindeks Disease Interaction
Major: inflammatory bowel disease, intestinal obstruction disorders, acute surgical abdomen, rectal bleeding
Volume of Distribution
Data regarding the volume of distribution of bisacodyl is not readily available. However, the volume of distribution of the active metabolite, BHPM, in lactating women is 181 L after a single dose and 289 L at steady state.
Elimination Route
Oral formulations of bisacodyl are only 16% bioavailable. A 10 mg enteric coated oral tablet reaches a Cmax of 26 ng/mL with a Tmax of 8 hours, while a 10 mg oral solution reaches a Cmax of 237 ng/mL with a Tmax of 1.7 hours. A 10 mg suppository reaches a Cmax of 0-64 ng/mL.
In lactating women, 10mg of oral bisacodyl reaches a Cmax of 20.5-195 ng/mL, with a Tmax of 3-4 hours, and a geometric mean AUC after a single dose of 471 h*ng/mL. After multiple doses, the geometric mean AUC decreases to 311 h*ng/mL.
Half Life
Data regarding the half life of bisacodyl is not readily available. The half life of the active metabolite, BHPM, in lactating women was 7.3 h after a single 10 mg oral dose and 10.0 h after multiple doses.
Clearance
Data regarding the clearance of bisacodyl is not readily available. The apparent plasma clearance of the active metabolite, BHPM, in lactating women after a single 10 mg oral dose is 272 mL/min and after multiple doses is 412 mL/min.
Elimination Route
The majority of bisacodyl is eliminated in the feces. 13.8-17.0% of a bisacodyl dose is eliminated in the urine as the active metabolite BHPM.
Pregnancy & Breastfeeding use
Bisacodyl-Grindeks has been assigned to pregnancy category B by the FDA. Animal studies have failed to reveal evidence of teratogenicity or fetotoxicity. No data are available from controlled human pregnancy studies. Bisacodyl-Grindeks should only be given during pregnancy when need has been clearly established.
It is not known whether this drug is excreted in human milk. Because many drugs are excreted in human milk, caution should be exercised when HalfLytely and Bisacodyl-Grindeks Tablets Bowel Prep Kit is administered to a nursing woman.
Contraindication
Bisacodyl-Grindeks is contraindicated in ileus, intestinal obstruction, acute surgical abdominal conditions, severe dehydration. Appendicitis & acute inflammatory bowel diseases.
Acute Overdose
A laxative is a medicine used to produce bowel movements. Laxative overdose occurs when someone takes more than the normal or recommended amount of this medicine. This can be by accident or on purpose.
Most laxative overdoses in children are accidental. However, some people regularly take overdoses of laxatives to try to lose weight.
Storage Condition
Store at room temperature, between 15°C to 30°C. Store in a tightly closed container away from heat, moisture, and light.
Innovators Monograph
You find simplified version here Bisacodyl-Grindeks
Bisacodyl-Grindeks contains Bisacodyl see full prescribing information from innovator Bisacodyl-Grindeks Monograph, Bisacodyl-Grindeks MSDS, Bisacodyl-Grindeks FDA label
FAQ
What is Bisacodyl-Grindeks used for?
Bisacodyl-Grindeks can help you empty your bowels if you have constipation.Bisacodyl-Grindeks is also used in hospitals to help you empty your bowels before surgery or some examinations or treatments.
How safe is Bisacodyl-Grindeks?
Bisacodyl-Grindeks is safe and effective when used according to directions on the drug facts label.
How does Bisacodyl-Grindeks work?
Bisacodyl-Grindeks works by increasing activity of the intestines to cause a bowel movement.
What are the common side effects of Bisacodyl-Grindeks?
The most common side effects are feeling sick nausea, diarrhoea, stomach pain or cramps. Only give Bisacodyl-Grindeks to children and young people if a doctor or pharmacist recommends it. Do not take Bisacodyl-Grindeks tablets or use Bisacodyl-Grindeks suppositories every day for more than 5 days.
Is Bisacodyl-Grindeks safe during pregnancy?
Bisacodyl-Grindeks tablets or suppositories are not generally recommended if you are pregnant.
Is Bisacodyl-Grindeks safe during breastfeeding?
Bisacodyl-Grindeks is not absorbed from the gastrointestinal tract, and its active metabolite, which is absorbed, is not detectable in breastmilk.Bisacodyl-Grindeks can be taken during breastfeeding and no special precautions are required.
Can I drink alcohol with Bisacodyl-Grindeks?
Yes, you can drink alcohol with Bisacodyl-Grindeks.
What is the best time to take Bisacodyl-Grindeks?
Bisacodyl-Grindeks tablets take about 10-12 hours to work; therefore, they are best taken at bedtime. Do not chew or break the tablets. A suppository can be used instead of taking tablets.
Why is Bisacodyl-Grindeks taken at night?
Bisacodyl-Grindeks is usually taken the evening before a bowel movement is desired.Bisacodyl-Grindeks normally causes a bowel movement within 6 to 12 hours.
How long does Bisacodyl-Grindeks last?
The elimination half life of Bisacodyl-Grindeks is 16 hours. This means that the bowel stimulant medication is metabolized in the body and roughly half is gone after 16 hours with half the remaining medicine gone after another 16 hours.
Can Bisacodyl-Grindeks help weight loss?
Bisacodyl-Grindeks do not help with weight loss. They do not reduce the absorption of calories or nutrients.
Who should not take Bisacodyl-Grindeks?
Follow all directions on your medicine label and package. Tell each of your healthcare providers about all your medical conditions, allergies, and all medicines you use.
What happens if I miss a dose o fBisacodyl-Grindeks?
Since Bisacodyl-Grindeks is used when needed, it does not have a daily dosing schedule.
If you are preparing for a medical test and you miss your dose, call your doctor for instructions.
What happens if I overdose of Bisacodyl-Grindeks?
Symptoms of overdose may include: severe stomach/abdominal pain or cramping, persistent nausea/vomiting/diarrhea. Keep all regular medical and laboratory appointments.
How many Bisacodyl-Grindeks can I take in a day?
Do not take Bisacodyl-Grindeks more than once a day or for more than 1 week without talking to your doctor.
Can Bisacodyl-Grindeks cause miscarriage?
No, Bisacodyl-Grindeks is not safe or recommended in pregnancy, especially during the first trimester, as it may cause birth defects or a miscarriage in the mother's womb.
Can Bisacodyl-Grindeks help weight loss?
Bisacodyl-Grindeks do not help with weight loss. They do not reduce the absorption of calories or nutrients.
Is Bisacodyl-Grindeks safe for long-term use?
Do not use this medicine for longer than directed by your doctor or health care professional. This medicine can be habit-forming. Long-term use can make your body depend on the laxative for regular bowel movements, damage the bowel, cause malnutrition, and problems with the amounts of water and salts in your body.
What happens if I take Bisacodyl-Grindeks everyday?
Do not take Bisacodyl-Grindeks every day for more than 5 days. If you take Bisacodyl-Grindeks for longer, your body can start to rely on it, rather than your bowels doing the work on their own. If you are still constipated after 5 days, talk to your doctor.
Can I take Bisacodyl-Grindeks in the morning?
Use one suppository daily. It will take between 10-60 minutes to work and therefore should preferably be used in the morning. It will usually have its effect within 30 minutes.
