Bola Resin

Bola Resin Uses, Dosage, Side Effects, Food Interaction and all others data.

Extractives and their physically modified derivatives such as tinctures, concretes, absolutes, essential oils, oleoresins, terpenes, terpene-free fractions, distillates, residues, obtained from Commiphora abyssinica, Burseraceae.

Bola Resin reduces the production of cytokines and reduces the effects of inflammation . It is also suggested to produce an analgesic effect . Bola Resin produces cell damage and death in various cancer cell types . Bola Resin has been observed to exert anantibacterial, antiparasitic, and antifungal activities . Bola Resin reduces liver injury in response to carbon tetrachloride insult, suggesting hepoprotective action . It also displays antioxidant properties . Bola Resin reduces low density lipoprotein levels . Bola Resin appears to be cardioprotective, producing a decrease in heart rate and restoring blood pressure in response to isoproteronol challenge . Bola Resin lowers plasma glucose and insulin levels in type 2 diabetes mellitus models suggesting an improvement in insulin sensitivity . Bola Resin has been observed to protect against both substance and stress induced gastric lesions .

Trade Name Bola Resin
Generic Myrrh
Myrrh Other Names Bola resin, Commiphora molmol resin, Commiphora myrrha gum resin, Commiphora myrrha resin, Commiphora myrrha resin extract, Common myrrh, Hirabol myrrh, Mo yao, Moyao (commiphora molmol), Moyao (commiphora myrrha), Myhrra, Myrrh, Myrrh (commiphora molmol), Myrrh (commiphora myrrha), Myrrha
Type
Groups Approved
Therapeutic Class
Manufacturer
Available Country
Last Updated: September 19, 2023 at 7:00 am
Bola Resin
Bola Resin

Uses

FDA approved only for use in food. Historically used for indigestion, ulcers, colds, cough, asthma, bronchial congestion, arthritic pain, cancer, leprosy, and syphilis. It is also used orally as a stimulant, antispasmodic, and to increase menstrual flow. Topically, myrrh is used for mild inflammation of the oral and pharyngeal mucosa, aphthous ulcers, gingivitis, chapped lips, hemorrhoids, bedsores, wounds, abrasions, furunculosis, bad breath, and loose teeth. In foods and beverages, myrrh is used as a flavoring component. In manufacturing, myrrh is used as a fragrance and fixative in cosmetics. It is also used in embalming and as incense.

How Bola Resin works

Anti-inflammatory: Bola Resin is thought to mediate its anti-inflammatory activity through inducing haem oxygenase activity . Haem oxygenase then appears to prevent the degradation of IKBalpha in response to inflammatory receptor activation. This prevents translocation of nuclear factor kappaB (NFkappaB) to the nucleus and inhibits the expression of genes under its control like cyclooxygenase-2 and the inducible form of nitric oxide synthase. The suppression of the NFkappaB pathway likely also reduces the expression of inflammatory cytokines. Myrhh also inhibits the mitogen activated protein kinase (MAPK) pathway, specifically producing inhibition of p38 and c-jun N-terminal kinase (JNK) . This is associated with a reduction in c-jun and c-fos expression which would likely result in a reduction in activator protein-1 and and inhibition of its associated inflammatory gene expression. Bola Resin exibits inhibitory activity against 5-lipoxygenase helping to suppress the production of leukotrienes, another class of inflammatory cytokine . In addition to its effects on the NFkappaB system, myrrh also inhibits the signal transducer and activator of transcription (STAT) -1 and -3 resulting in a decrease in cytokine production by the janus kinase/STAT pathway . Bola Resin also reduces the downregulation of suppresor of cytokine synthesis (SOCS) in response to interleukin-1beta and interferon-gamma. SOCS serves as an autoregulator of the JAK/STAT pathway under transcriptional control of STATs and inhibits activation of the pathway.

Analgesic: Bola Resin appears to produce an analgesic effect associated with its suppression of prostaglandin production . Bola Resin is also suggested to block inward sodium currents .

Anticancer: Bola Resin displays an pro-apoptotic effect on cancer cells . This seems to involve members of the Bcl family of proteins . Bola Resin induces the expression of the pro-apoptotic protein Bax while decreasing the expression of Bcl-2 and Bcl-xl, the anti-apoptotic members of the Bcl family. At low doses Bola Resin seems to activate the MAPK pathway in cancer cells, promoting the phosphorylation of p38 and JNK . The JNK activation in particular appears to mediate an apoptotic influence. Additionally, myrrh appears to induce reactive oxygen species generation in cancer cells further promoting apoptosis.

Antibacterial/Antiparasitic/Antifungal: The precise antibacterial, antiparasitic, and antifungal mechanisms of myrrh are unknown .

Hepatoprotective: Bola Resin has been shown to reduce liver injury and upregulation of superoxide dismutase, glutathione peroxidase and catalase in response to carbon tetrachloride insult. This is thought to be due to anti-oxidant properties of myrrh .

Antioxidant: The precise mechanism of myrrh's antioxidant property is unknown.

Lipid lowering: Compounds in myrrh bind to and inhibit the farnesoid X receptor resulting in a reduction in low density lipoprotein . This effect is likely to due the attenuation of the suppression of bile synthesis and a reduction in ileal bile acid binding protein in response to farnesoid X receptor stimulation [A19610]. Together these would ensure processing of cholesterol into bile and subsequent loss of that bile by reducing reuptake.

Cardioprotective: The exact mechanism of myrrh's cardioprotective effect is unknown.

Antidiabetic: Much of myrrh's antidiabetic action is attrbutable to it's anti-inflammatory action which protects islet beta cells from inflammatory damage during hyperglycemia . The antioxidant properties of myrrh also likely contribute to this effect.

Antiulcer: The antiulcer activity of myrrh is suggested to be due to inhibition of gastric acid secretion, increasing gastric mucus secretion, and myrrh's antioxidant properties .

Toxicity

Oral LD50 for myrrh oil in rats is 1650mg/kg . The Commiphora erlangeriana species is poisonous to humans and other mammals .

Food Interaction

No interactions found.

Innovators Monograph

You find simplified version here Bola Resin

*** Taking medicines without doctor's advice can cause long-term problems.
Share