Bolt Topical Gel 0.2%+2%
Bolt Topical Gel 0.2%+2% Uses, Dosage, Side Effects, Food Interaction and all others data.
Salicylic acid has a potent keratolytic action and a slight antiseptic action when applied topically. It softens and destroys the stratum corneum by increasing endogenous hydration which causes the horny layer of the skin to swell, soften, and then desquamate. At high concentrations, salicylic acid has a caustic effect. It also possesses weak antifungal and antibacterial activity.
Salicylic acid treats acne by causing skin cells to slough off more readily, preventing pores from clogging up. This effect on skin cells also makes salicylic acid an active ingredient in several shampoos meant to treat dandruff. Use of straight salicylic solution may cause hyperpigmentation on unpretreated skin for those with darker skin types (Fitzpatrick phototypes IV, V, VI), as well as with the lack of use of a broad spectrum sunblock. Subsalicylate in combination with bismuth form the popular stomach relief aid known commonly as Pepto-Bismol. When combined the two key ingredients help control diarrhea, nausea, heartburn, and even gas. It is also very mildly anti-biotic.
| Trade Name | Bolt Topical Gel 0.2%+2% |
| Generic | Mucopolysaccharide Polysulphate + Salicylic Acid |
| Weight | 0.2%+2% |
| Type | Topical Gel |
| Therapeutic Class | |
| Manufacturer | Incepta Pharmaceuticals Ltd. |
| Available Country | Bangladesh |
| Last Updated: | October 19, 2023 at 6:27 am |
Uses
This gel is indicated for mild to moderate anti-inflammatory, analgesic, symptomatic relief of muscular pain, stiffness, sprains, strains, pain due to rheumatic & non-serious arthritic conditions.Bolt Topical Gel 0.2%+2% is also used to associated treatment for these conditions: Contusions, Inflammation of the superficial Veins, Vessels; VaricoseAcne, Actinic Keratosis (AK), Alopecia Areata (AA), Atopic Dermatitis (AD), Blackheads, Chronic Eczema, Chronic cutaneous lupus erythematosus, Corns, Dandruff, Dermatitis, Contact, Dermatitis, Eczematous, Dermatitis, Eczematous of the scalp, Discoid Lupus Erythematosus (DLE), Foot Callus, Fungal skin infection, Furuncle, Hand Eczema, Hyperkeratosis, Hyperkeratosis follicularis et parafollicularis, Infections, Fungal, Infections, Fungal of the Skin Folds, Infections, Fungal of the face, Infections, Fungal of the feet, Infections, Fungal of the hand, Keratosis Palmaris et Plantaris, Lichen, Lichen Plano-Pilaris, Lichen Planus (LP), Lichen simplex chronicus, Molluscum Contagiosum, Musculoskeletal Pain, Neurodermatitis, Palmo-Plantar Pustulosis, Plantar Warts, Pruritus, Psoriasis, Psoriasis Vulgaris (Plaque Psoriasis), Psoriasis of the scalp, Rash, Ringworm of the Skin, Ringworm of the scalp, Seborrheic Dermatitis, Seborrhoeic Dermatitis of the Scalp, Skin Infections, Bacterial, Verrucous Psoriasis, Warts, Calluses, Corticosteroid-responsive dermatoses, Keratinization disorders, Scaling, Scaling of skin, Scalp seborrhea, Superficial Fungal skin infection, Keratolysis
How Bolt Topical Gel 0.2%+2% works
Salicylic acid directly irreversibly inhibits COX-1 and COX-2 to decrease conversion of arachidonic acid to precursors of prostaglandins and thromboxanes. Salicylate's use in rheumatic diseases is due to it's analgesic and anti-inflammatory activity. Salicylic acid is a key ingredient in many skin-care products for the treatment of acne, psoriasis, calluses, corns, keratosis pilaris, and warts. Salicylic acid allows cells of the epidermis to more readily slough off. Because of its effect on skin cells, salicylic acid is used in several shampoos used to treat dandruff. Salicylic acid is also used as an active ingredient in gels which remove verrucas (plantar warts). Salicylic acid competitively inhibits oxidation of uridine-5-diphosphoglucose (UDPG) with nicotinamide adenosine dinucleotide (NAD) and noncompetitively with UDPG. It also competitively inhibits the transferring of the glucuronyl group of uridine-5-phosphoglucuronic acid (UDPGA) to a phenolic acceptor. Inhibition of mucopoly saccharide synthesis is likely responsible for the slowing of wound healing with salicylates.
Dosage
Bolt Topical Gel 0.2%+2% dosage
Adults, the elderly and children over 12 years of age: Two to six inches (5-15 cm) to be massaged to the affected area up to four times a day.Use in Childhood and Adolescence: Should not be used on children below 12 years old.Side Effects
Like all medicines, this gel preparation can cause side effects, although not everybody gets them. Rarely, this medicine can cause the following in sensitive individuals: redness, burning sensation and rash. If any of these occur, stop using the gel and consult with a doctor.Toxicity
Oral rat LD50: 891 mg/kg. Inhalation rat LC50: > 900 mg/m3/1hr. Irritation: skin rabbit: 500 mg/24H mild. Eye rabbit: 100 mg severe. Investigated a mutagen and reproductive effector.
Precaution
For external use only. Keep away from the eyes. The stated dose should not be exceeded. If the condition persists or worsens, consult a doctor or pharmacist. Side effects of salicylates are theoretically possible. Cunsult with a doctor before use if pregnant, breast-feeding, asthmatic, have pre-existing renal damage or on any prescribed medicines (inc. coumarin anticoagulants). Salicylic acid may increase skin permeability for other topically applied medicines. Some people may experience discomfort, particularly those with sensitive skin or if used in hot weather or after a bath. Wash hands immediately after use. Discontinue use if excessive irritation or other unwanted effects occur.Interaction
Drugs or herbal products that may decrease the effectiveness of HCs include efavirenz, phenytoin, barbiturates, carbamazepine, bosentan, felbamate, griseofulvin, oxcarbazepine, rifampicin, rifabutin, rufinamide, aprepitant. Interactions between HCs and other drugs may lead to breakthrough bleeding and/or contraceptive failure. There is a potential for an increase in serum potassium concentration in females taking SLYND with other drugs that may increase serum potassium concentration. For example, ACE inhibitors, angiotensin-ll receptor antagonists, potassium-sparing diuretics, potassium supplementation, heparin, aldosterone antagonists, and NSAIDs.Volume of Distribution
The volume of distribution is about 170 mL/kg of body weight.
Elimination Route
About 10% is excreted unchanged in the urine.
Pregnancy & Breastfeeding use
If you are pregnant or breastfeeding, think you may be pregnant or are planning to have a baby, ask your doctor for advice before taking this medicine. Gel should not be used during the first three or last three months of pregnancy or on the breast area during breastfeeding/lactation.Contraindication
Hypersensitivity to any of the ingredients, aspirin or other non-steroidal anti-inflammatory drugs (including when taken by mouth) especially where associated with a history of asthma. Not to be used on large areas of skin, broken, sensitive or infected skin, eczema or on mucous membranes. Not to be used on children under 12 years of age. Do not use during the first trimester, during late pregnancy or on the breast area during lactation.Special Warning
Salicylic Acid is used in children over 2 years.
Acute Overdose
An overdose of Salicylic Acid topical is unlikely to occur. If you do suspect an overdose or if the medication has been ingested, call a poison control center or emergency room for advice.
Storage Condition
Keep below 30°C temperature, away from light & moisture. Keep out of the reach of children.Innovators Monograph
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