Bonemac

Bonemac Uses, Dosage, Side Effects, Food Interaction and all others data.

Calcium phosphate is typically available as an over the counter supplement, antacid, or as an added ingredient in some toothpastes .

Calcium phosphate reacts with acid in the stomach to raise the pH . In toothpaste it provides a source of calcium and phosphate ions to support remineralization of the teeth . As a supplement it provides a source of calcium and phospate, both of which are important ions in bone homeostasis.

Zinc gluconate is a zinc salt of gluconic acid comprised of two gluconic acid molecules for each zinc cation (2+). Zinc gluconate is a generally recognized as safe (GRAS) substance by FDA . It is available as a trace mineral supplement and over the counter as a lozenge form for a reduced duration of common colds and with decreased symptom severity.

Although it has been nasally administered for treating the common cold, this route of administration has been associated with some cases of anosmia , , , .

Studies show that zinc may be better absorbed in humans in the gluconate form , , however, results from other studies may vary , [L27280].

Bonemac
Uses
Dosage
Side Effect
Precautions
Interactions
Uses during Pregnancy
Uses during Breastfeeding
Accute Overdose
Food Interaction
Half Life
Volume of Distribution
Clearance
Interaction With other Medicine
Contradiction
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Trade Name	Bonemac
Generic	Zinc Gluconate + Calcium Phosphate + Vitamin D3 / Cholecalciferol + Magnesium Hydroxide / Milk Of Magnesia
Weight	4mg
Type	Suspension
Therapeutic Class
Manufacturer	Wilburt Remedies Pvt Ltd
Available Country	India
Last Updated:	September 19, 2023 at 7:00 am

Uses

Calcium Phosphate is a compound used in supplements and antacids.

For use as an over the counter calcium and phosphate supplement, antacid, or a source of calcium and phosphate in toothpaste .

Zinc gluconate is an ingredient found in a variety of supplements and vitamins.

Zinc gluconate is mainly indicated in conditions like zinc deficiency, and can also be administered in adjunctive therapy as an alternative drug of choice in diarrhea .

Bonemac is also used to associated treatment for these conditions: Calcium Deficiency, Calcium and Vitamin D Deficiencies, Phosphate Deficiency, Dental CareZinc Deficiency

How Bonemac works

The phosphate ions in calcium phosphate likely react with hydrochloric acid in the stomach to neutralize the pH. In toothpaste and in systemic circulation, calcium phosphate provides a source of calcium and phosphate ions to support remineralization of the teeth and bone homeostasis respectively. The increase in plasma calcium reduces calcium flux from osteocyte activity by reducing the secretion of parathyroid hormone (PTH) . Calcium does this by stimulating a G-protein coupled calcium receptor on the surface of parathyroid cells. The reduction in calcium flux increases the amount of calcium deposited in bone resulting in an increase in bone mineral density. The reduction in PTH secretion also reduces the amount of vitamin D metabolized to its active form, calcidiol. Since calcidiol increases the expression of calcium dependent ATPases and transient receptor potential cation channel subfamily V member 6 (TRPV6) both of which are involved in calcium uptake from the gut, a reduction in calcidiol results in less calcium absorption. Additionally, TRPV5, the channel responsible for calcium reabsorption in the kidney, is downregulated when PTH secretion is reduced thus increasing calcium excretion via the kidneys. Another hormone, calitonin, is likely involved in the reduction of bone resorption during periods of high plasma calcium.

Although the mechanism of action is not completely known, zinc supplementation may be used to increase immunity against viruses or may interfere with the replication of certain viruses, such as the human papillomavirus (HPV) .

Toxicity

Nausea, vomiting, diarrhea, and mouth irritation have been reported in patients ingesting zinc gluconate tablets that were dissolved in the mouth for management the common cold .

Zinc crosses the placenta and is found the cord blood and placenta. Fetal concentrations are regulated by the placenta .

For more information, refer to Please refer to DrugBank entry Zinc.

Acute: 1290 mg/kg in mouse